Research Projects:

1. Mechanistic Study on Transporter SLC7A2 Promoting Atrogin-1 S-Nitrosylation to Ameliorate Sarcopenia
   National Natural Science Foundation of China (Regional Project), Grant No. 82560284
   January 1, 2026 – December 31, 2029 | RMB 320,000
   Role: Principal Investigator | Status: Active

2. Functional Mechanisms of the Centipede Hibernation Peptide Ssm2 in Inhibiting Protein Ubiquitination and Degradation to Delay Sarcopenia
   Jiangxi Provincial Natural Science Foundation (Youth Project), Grant No. 20252BAC200654
   June 1, 2025 – May 31, 2028 | RMB 100,000
   Role: Principal Investigator | Status: Active

3. Identification of Allergens from the Chinese Medicinal Centipede Scolopendra subspinipes mutilans and Investigation of Its Allergic Mechanisms
   Yunnan Provincial Basic Research Special Program (Youth Project), Grant No. 202001AU070149
   January 1, 2020 – December 31, 2022 | RMB 50,000
   Role: Principal Investigator | Status: Completed

Publications：

1.Wang Q^#, Li J^#, Yang M^#, Guo C^#, Zhang M, Huang C, Wang X, Zhang D, Zeng L, Ke H, Wen Y, Li S, Lee W, Zhao L, Lan X*, Xiang Y*. (2026) Peptide OH-CATH30 Mitigates Cachexia-Induced Muscle Atrophy via Modulation of TLR4-Associated Inflammation. J Cachexia Sarcopenia Muscle. Feb;17(1):e70195.

2.Guo, CF#., Lan, XQ#., Huang, CP#., Wang, X., Zhang, DQ., Zeng, L., Wang, QQ*., Xiang Y*., Li J*. Muscle-specific transcriptomic and metabolomic signatures reveal heterogeneous aging trajectories and altered intercellular communication in male murine skeletal muscle. Biogerontology. 2026. (in press).

3. Li, Jian#., Lan, XQ#., Guo, CF#., Wang, X #., Huang, CP., Zhang, DQ., Zeng, L., Tian, XL., Xiang, Y*., Wang, QQ*. Comprehensive Multi-PTM profiling reveals age-associated remodeling in skeletal muscle. Zoological Research. 2026. (in press).

2025

4. Lan, X^#., Yang, M^#., Wang, J^#., Huang,C., Wu, A., Cui, L., Guo, Y.., Zeng, L., Guo, X., Zhang, Y., Xiang, Y^*., Wang, Q^*. (2025) Pore-Forming Protein LIN-24 Enhances Starvation Resilience in Caenorhabditis elegans by Modulating Lipid Metabolism and Mitochondrial Dynamics. 17, (2025):72. Toxins.

5.Liu, Y^#., Wang, Q-Q^#., Huang, T-E^#., Yao, M., Wang, B-H., Huang, C-P., Wang, S., Lu, Y-F., Lan, X-Q., Tian, X-L*. and Xiang, Y*. (2025). Aldehyde Oxidase 1 Deficiency Enhances Aerobic Exercise Performance by Promoting Skeletal Muscle Adaptation and Improving Mitochondrial Function. The FASEB Journal, 39(14), p.e70815.

6. Wang, Q^#., Yao, M^#., Wang, X^#., Lan, X., Fan, G. and Xiang, Y*. (2025). From Liver to Muscle: Crosstalk Mechanisms and Interventions in Sarcopenia. Health and Metabolism.

2024

7. Zhang, H-J^#., Wang, B-H^#., Wang, X^#., Huang, -CP^#., Xu, S-M., Wang, J-L., Huang, T-E., Xiao, W-L., Tian, X-L., Lan, X-Q^*., Wang, Q-Q^*., Xiang Y^*. (2024) Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation. 15, 173-188. Journal of cachexia, sarcopenia and muscle.

8. Wang, Q-Q^#., Lan, X-Q^#., Ke H^#., Xu, S-M^#., Huang, C-P^#., Wang, J-L., Huang, T-E., Tian, X-L., Xiang, Y^*. (2024). Histone β-hydroxybutyrylation is critical in reversal of sarcopenia. Aging cell. 30:e14284.

9.  Lan, X-Q^#., Deng, C-J^#., Wang, Q-Q., Zhao, L-M., Jiao, B-W., & Xiang, Y*. (2024). The Role of TGF-β Signaling in Muscle Atrophy, Sarcopenia and Cancer Cachexia. General and Comparative Endocrinology, 2024, 353(114513). 0016-6480.

10. Xiao, W., Huang, TE., Zhou, J., Wang, B., Wang, X., Zeng, W., Wang, Q., Lan, X., Xiang, Y*. (2024). Inhibition of MAT2A Impairs Skeletal Muscle Repair Function. Biomolecules.14(9),1098.

2023

11. Huang, T., Zhou, J., Wang, B., Wang, X., Xiao, W., Yang, M., ... Xiang, Y^*& Lan, X^*. (2023). Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation. International Journal of Molecular Sciences, 25(1), 95.

12. Zhang Huijie, Zeng Weirong, Zhao Ming-ming, Wang Jiali, Wang Qiquan, Chen Ting, Zhang Yuyan, Lee Wenhui, Chen Shenghan, Zhang Yun *, Lan Xinqiang*, Xiang Yang*. (2023). Caenorhabditis elegans LIN‐24, a homolog of bacterial pore‐forming toxin, protects the host from microbial infection. The FASEB Journal, 37(10):e23162.

13. Wang, Q-Q^*#. Lan, X-Q^#., Wei, X-S., Liu, L-Z et al. (2023) Amphibian pore-forming protein βγ-CAT drives metabolites release from small extracellular vesicles through channel formation. Zoological research.

2022

14. Zhang H^#, Qin J^#, Lan X^#, Zeng W, Zhou J, Huang TE, Xiao W-L, Wang Q-Q, Sun S, Su W, Nie W, Yang S, Yang J, Gao Q, Xiang Y*. Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function. Biogerontology, 2022, 23 (1), 115-128.

15. Fu, T.T^#., Sun, Y.B^#., Gao, W^#., Long, C.B^#., Yang, C.H., Yang, X.W., Zhang, Y., Lan, X.Q., Huang, S., Jin, J.Q., Murphy, R.W., Zhang, Y*., Lai, R*., Hillis, D.M*., Zhang, Y.P*., Che, J*. (2022). The highest-elevation frog provides insights into mechanisms and evolution of defenses against high UV radiation. Proc Natl Acad Sci U S A,15;119(46), e2212406119.

16. Xiang, Y^#*., Wang, Q-Q^#. Lan, X-Q., Zhang, H-J. (2022) Function and treatment strategies of β-hydroxybutyrate in aging. Smart Materials in Medicine 4, 160-172.

2021

17. Lan, X-Q^#., Zhao, F^#., Wang, Q-Q., Li, J-H., Zeng, L., Zhang, Y^*., & Lee, W-H^*. (2021). Isolation and characterization of the major centipede allergen Sco m 5 from Scolopendra subspinipes mutilans. Allergology International, 70(1), 121-128

18.Liu, Z-C^#., Liang, J.Y^#., Lan, X-Q., Li, T., Zhang, J-R., Zhao, F., Li, G., Chen, P.-., Zhang, Y., Lee, W-H*., Zhao, F*,. Comparative analysis of diverse toxins from a new pharmaceutical centipede, Scolopendra mojiangica. (2020). Zool Res, 18, 41(2), 138-147.

19. Zhao, F^#., Lan, X^#., Li, T., Xiang, Y., Zhao, F., Zhang, Y*., & Lee, W. H*. (2018). Proteotranscriptomic analysis and discovery of the profile and diversity of toxin-like proteins in centipede. Molecular & Cellular Proteomics, 17(4), 709-720.

20. Zhao, F., Lan, X.Q., Du, Y., Chen, P.Y., Zhao, J., Zhao, F., Lee, W.H*., Zhang, Y*. (2018). King cobra peptide OH-CATH30 as a potential candidate drug through clinic drug-resistant isolates. Zool Res, 18, 39(2), 87-96.

Patents:

1. Application of YE6144 in the Preparation of Pharmaceuticals for Treating Breast Cancer-Induced Skeletal Muscle Atrophy
   Patent No.: ZL 2024 1 1774438.5
   Date of Grant: April 1, 2025
   Inventors: Lan Xinqiang, Yang Mengqi, Li Jian, Wang Qiquan, Xiang Yang, Cui Leilei, Su Yu
   Year: 2026

2. Application of OH-CATH30 in the Preparation of Pharmaceuticals for Treating Skeletal Muscle Atrophy
   Patent No.: ZL 2024 1 1813799.6
   Date of Grant: April 1, 2025
   Inventors: Wang Qiquan, Yang Mengqi, Li Jian, Xiang Yang, Lan Xinqiang, Cui Leilei, Su Yu

3.