姓名:兰新强
国籍:中国
性别:女
毕业院校:中国科学院大学
职称:助理研究员
学位:博士
职称类别:中级
岗位级别:专技岗8级
电子邮件:lanxinqiang@ncu.edu.cn
所在单位:生命科学学院
办公地址:理生楼B307A/B
研究方向:
肌少症的小分子干预
[1] 201409-201906 中国科学院大学 博士研究生
[2] 201009-201406 云南大学 大学本科
[1] 202005-202101 普洱学院 普洱学院
中药少棘蜈蚣过敏原的鉴定及过敏机制研究
转运体SLC7A2促进Atrogin-1 S-亚硝基化改善肌少症的机制研究
蜈蚣冬眠多肽Ssm2抑制蛋白质泛素化降解延缓肌少症的功能机制
基于数理统计学的加热卷烟再造烟叶差异性对比研究-1-兰新强
烟草转运蛋白和酶相关基因的红大编辑素材库创制与鉴定-1-兰新强
发表论文:
2026
1.Wang Q#, Li J#, Yang M#, Guo C#, Zhang M, Huang C, Wang X, Zhang D, Zeng L, Ke H, Wen Y, Li S, Lee W, Zhao L, Lan X*, Xiang Y*. (2026) Peptide OH-CATH30 Mitigates Cachexia-Induced Muscle Atrophy via Modulation of TLR4-Associated Inflammation. J Cachexia Sarcopenia Muscle. Feb;17(1):e70195.
2.Guo, CF#., Lan, XQ#., Huang, CP#., Wang, X., Zhang, DQ., Zeng, L., Wang, QQ*., Xiang Y*., Li J*. Muscle-specific transcriptomic and metabolomic signatures reveal heterogeneous aging trajectories and altered intercellular communication in male murine skeletal muscle. Biogerontology. 2026. (in press).
3. Li, Jian#., Lan, XQ#., Guo, CF#., Wang, X #., Huang, CP., Zhang, DQ., Zeng, L., Tian, XL., Xiang, Y*., Wang, QQ*. Comprehensive Multi-PTM profiling reveals age-associated remodeling in skeletal muscle. Zoological Research. 2026. (in press).
2025
4. Lan, X#., Yang, M#., Wang, J#., Huang,C., Wu, A., Cui, L., Guo, Y.., Zeng, L., Guo, X., Zhang, Y., Xiang, Y*., Wang, Q*. (2025) Pore-Forming Protein LIN-24 Enhances Starvation Resilience in Caenorhabditis elegans by Modulating Lipid Metabolism and Mitochondrial Dynamics. 17, (2025):72. Toxins.
5.Liu, Y#., Wang, Q-Q#., Huang, T-E#., Yao, M., Wang, B-H., Huang, C-P., Wang, S., Lu, Y-F., Lan, X-Q., Tian, X-L*. and Xiang, Y*. (2025). Aldehyde Oxidase 1 Deficiency Enhances Aerobic Exercise Performance by Promoting Skeletal Muscle Adaptation and Improving Mitochondrial Function. The FASEB Journal, 39(14), p.e70815.
6. Wang, Q#., Yao, M#., Wang, X#., Lan, X., Fan, G. and Xiang, Y*. (2025). From Liver to Muscle: Crosstalk Mechanisms and Interventions in Sarcopenia. Health and Metabolism.
2024
7. Zhang, H-J#., Wang, B-H#., Wang, X#., Huang, -CP#., Xu, S-M., Wang, J-L., Huang, T-E., Xiao, W-L., Tian, X-L., Lan, X-Q*., Wang, Q-Q*., Xiang Y*. (2024) Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation. 15, 173-188. Journal of cachexia, sarcopenia and muscle.
8. Wang, Q-Q#., Lan, X-Q#., Ke H#., Xu, S-M#., Huang, C-P#., Wang, J-L., Huang, T-E., Tian, X-L., Xiang, Y*. (2024). Histone β-hydroxybutyrylation is critical in reversal of sarcopenia. Aging cell. 30:e14284.
9. Lan, X-Q#., Deng, C-J#., Wang, Q-Q., Zhao, L-M., Jiao, B-W., & Xiang, Y*. (2024). The Role of TGF-β Signaling in Muscle Atrophy, Sarcopenia and Cancer Cachexia. General and Comparative Endocrinology, 2024, 353(114513). 0016-6480.
10. Xiao, W., Huang, TE., Zhou, J., Wang, B., Wang, X., Zeng, W., Wang, Q., Lan, X., Xiang, Y*. (2024). Inhibition of MAT2A Impairs Skeletal Muscle Repair Function. Biomolecules.14(9),1098.
2023
11. Huang, T., Zhou, J., Wang, B., Wang, X., Xiao, W., Yang, M., ... Xiang, Y*& Lan, X*. (2023). Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation. International Journal of Molecular Sciences, 25(1), 95.
12. Zhang Huijie, Zeng Weirong, Zhao Ming-ming, Wang Jiali, Wang Qiquan, Chen Ting, Zhang Yuyan, Lee Wenhui, Chen Shenghan, Zhang Yun *, Lan Xinqiang*, Xiang Yang*. (2023). Caenorhabditis elegans LIN‐24, a homolog of bacterial pore‐forming toxin, protects the host from microbial infection. The FASEB Journal, 37(10):e23162.
13. Wang, Q-Q*#. Lan, X-Q#., Wei, X-S., Liu, L-Z et al. (2023) Amphibian pore-forming protein βγ-CAT drives metabolites release from small extracellular vesicles through channel formation. Zoological research.
2022
14. Zhang H#, Qin J#, Lan X#, Zeng W, Zhou J, Huang TE, Xiao W-L, Wang Q-Q, Sun S, Su W, Nie W, Yang S, Yang J, Gao Q, Xiang Y*. Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function. Biogerontology, 2022, 23 (1), 115-128.
15. Fu, T.T#., Sun, Y.B#., Gao, W#., Long, C.B#., Yang, C.H., Yang, X.W., Zhang, Y., Lan, X.Q., Huang, S., Jin, J.Q., Murphy, R.W., Zhang, Y*., Lai, R*., Hillis, D.M*., Zhang, Y.P*., Che, J*. (2022). The highest-elevation frog provides insights into mechanisms and evolution of defenses against high UV radiation. Proc Natl Acad Sci U S A,15;119(46), e2212406119.
16. Xiang, Y#*., Wang, Q-Q#. Lan, X-Q., Zhang, H-J. (2022) Function and treatment strategies of β-hydroxybutyrate in aging. Smart Materials in Medicine 4, 160-172.
2021
17. Lan, X-Q#., Zhao, F#., Wang, Q-Q., Li, J-H., Zeng, L., Zhang, Y*., & Lee, W-H*. (2021). Isolation and characterization of the major centipede allergen Sco m 5 from Scolopendra subspinipes mutilans. Allergology International, 70(1), 121-128
18.Liu, Z-C#., Liang, J.Y#., Lan, X-Q., Li, T., Zhang, J-R., Zhao, F., Li, G., Chen, P.-., Zhang, Y., Lee, W-H*., Zhao, F*,. Comparative analysis of diverse toxins from a new pharmaceutical centipede, Scolopendra mojiangica. (2020). Zool Res, 18, 41(2), 138-147.
19. Zhao, F#., Lan, X#., Li, T., Xiang, Y., Zhao, F., Zhang, Y*., & Lee, W. H*. (2018). Proteotranscriptomic analysis and discovery of the profile and diversity of toxin-like proteins in centipede. Molecular & Cellular Proteomics, 17(4), 709-720.
20. Zhao, F., Lan, X.Q., Du, Y., Chen, P.Y., Zhao, J., Zhao, F., Lee, W.H*., Zhang, Y*. (2018). King cobra peptide OH-CATH30 as a potential candidate drug through clinic drug-resistant isolates. Zool Res, 18, 39(2), 87-96.
专利:
1. YE6144在制备治疗乳腺癌引起的骨骼肌萎缩药物中的应用,专利号:ZL 2024 1 1774438.5,授权公告日:2025年04月01日,专利发明人:兰新强、杨梦琪、李建、王齐权、向阳、崔磊磊、苏瑜;
2. OH-CATH30在制备治疗骨骼肌萎缩药物中的应用,专利号:ZL 2024 1 1813799.6,授权公告日:2025年04月01日,专利发明人:王齐权、杨梦琪、李建、向阳、兰新强、崔磊磊、苏瑜。