Scientific Research Achievements
Scientific Research Achievements
Number of papers published as first or corresponding author:
[1] Yu T, Li M, Zhang H, Hu J, Li M, Zhang Q, Liu X, Fu Z, Hu C*, Xu X*. Zebrafish ZDHHC11 palmitoylates STING to potentiate antiviral immune response. Cell Communication and Signaling, 2026.
[2] Zhao K, Zhang Y, Yin Z, Tan L, Juario M, Zhang H, Liu Y, Xu P, Zhang Q, Zhao G, Wang S, Mao H, Xu X*, Hu C*. GCRV-II major outer capsid protein VP4 promotes cell apoptosis by VDAC2-mediated calcium pathway facilitation. International Journal of Biological Macromolecules, 2025, 285, 138273.
[3] Guo R, Wu Y, Yu T, Guo C, Yin Z, Zhao G, Li M, Mao H, Hu C, Xu X*. Tetrachlorantraniliprole induces neurodevelopmental toxicity through oxidative stress-mediated apoptosis and dysregulation of Wnt signaling pathway. Aquatic Toxicology, 2025, 279, 107229.
[4] Zhang Y, Zhao K, Liu Y, Xu J, Zhang H, Yin Z, Xu P, Jiang Z, Wang S, Mao H, Xu X*, Hu C*. An oral probiotic vaccine loaded by Lactobacillus casei effectively increases defense against GCRV infection in grass carp. Vaccine, 2025, 45, 126660.
[5] Yu T, Li M, Li M, Wang S, Feng Z, Zhang H, Liu J, Mao H, Li D, Hu C*, Xu X*. Zebrafish (Danio rerio) TDP43 negatively regulates PKZ-IRF3–mediated IFN I response. Journal of Immunology, 2025, 214(4): 726-746.
[6] Yu T, Li M, Li M, Zhang Q, Zhang H, Jiang Z, Wang S, Mao H, Li D, Fan L, Hu C*, Xu X*. Zebrafish TDP43 positively regulates p65-mediated apoptotic pathway. International Journal of Biological Macromolecules, 2025, 27, 142599.
[7] Zhang Q, Yu T, Wang Z, Li M, Xu J, Liu X, Qian C, Yin Z, He G, Hu M, Zhang B, Liu J, Fu Z, Wang S*, Xu X*, Hu C. RBCK1 enhances antiviral response through promoting K63-linked polyubiquitination of IRF7 in Carassius auratus var. Pengze. Fish and Shellfish Immunology, 2025, 165, 110532.
[8] Zhang H, Liu X, Yin Z, Zhao K, Zhang Q, Yu T, Liu J, Zhang B, Hu M, Jiang Z, Li M, Wang S, Hu C*, Xu X*. ISGylation of zebrafish STING at lysines 221 and 276 activates innate immunity. Fish and Shellfish Immunology, 2025, 166, 110640.
[9] Guo C, Yu T, Guo R, Li M, Huang X, Wu Y, Tang J, Zhang Z, Wang S, Hu C*, Xu X*. Gpx4a-mediated ferroptosis underlines prothioconazole-induced ocular defects in early-life zebrafish. Water Biology and Security, 2025.
[10] Yin Z, Zhang H, Zhao K, Liu Y, Guo R, Xu P, Zhao G, Hu M, Hu C, Xu X*. Zebrafish FKBP5 facilitates apoptosis and SVCV propagation by suppressing NF-κB signaling pathway. Fish and Shellfish Immunology, 2024, 155, 110021.
[11] Li MM, Tao CB, Li MF, Wu CX, Yu TT, Feng ZQ, Zhang Q, Jiang ZY, Mao HL, Wang SH, Xu XW*, Hu CY*. A molecular mechanism underlies grass carp (Ctenopharyngodon idella) TARBP2 regulating PKR-mediated cell apoptosis. Fish and Shellfish Immunology, 2024, 154, 109906.
[12] Li M, Hu J, Zhou J, Wu C, Li D, Mao H, Kong L, Hu C*, Xu X*. Grass carp (Ctenopharyngodon idella) deacetylase SIRT1 targets p53 to suppress apoptosis in a KAT8 dependent or independent manner. Fish and Shellfish Immunology, 2023, 109264.
[13] Han X#, Xu X#, Yu T, Li M, Liu Y, Lai J, Mao H, Hu C, Wang S*. Dilfubenzuron Induces Cardiotoxicity in Zebraflsh Embryos. International Journal of Molecular Sciences, 2022, 23, 11932.
[14] Xiong Y, Wang C*, Dong M, Li M, Hu C, Xu X*. Chlorphoxim induces neurotoxicity in zebrafish embryo through activation of oxidative stress. Environmental Toxicology, 2022, 10: 1-13.
[15] Yu T, Zeng Q, Mao H*, Liu Y, Zhang H, Wang S, Hu C, Xu X*. Grass carp (Ctenopharyngodon idella) NLK2 inhibits IFN I response through blocking MAVS-IRF3 axis. Fish and Shellfish Immunology, 2022, 131: 206-217.
[16] Wang S, Han X, Yu T, Liu Y, Zhang H, Mao H, Hu C, Xu X*. Isoprocarb causes neurotoxicity of zebrafish embryos through oxidative stress-induced apoptosis. Ecotoxicology and Environmental Safety, 2022, 242, 113870.
[17] Li M, Hu J, Mao H, Li D, Jiang Z, Sun Z, Yu T, Hu C*, Xu X*. Grass Carp (Ctenopharyngodon idella) KAT8 inhibits IFN 1 response through acetylating IRF3/IRF7. Frontiers in Immunology, 2022, 12, 808159.
[18] Xu X, Li M, Deng Z, Li D, Lu S, Deng H, Lv Y, Liu Y, Du H, Hu C*. Grass carp Mre11A activates IFN 1 response by targeting STING to defend against GCRV infection. Developmental and Comparative Immunology, 2021,116, 103909.
[19] Xu X, Li M, Deng Z, Hu J, Jiang Z, Liu Y, Chang K, Hu C*. Grass Carp (Ctenopharyngodon idellus) NIMA-Related Kinase Blocks dsRNA-Induced IFN Response by Targeting IRF3. Frontiers in Immunology. 2021, 11, 597775.
[20] Li M, Yu T, Lai J, Han X, Hu J, Deng Z, Li D, Ye Z, Wang S, Hu C*, Xu X*. Ethoprophos induces cardiac toxicity in zebrafish embryos. Ecotoxicology and Environmental Safety. 2021, 228, 113029.
[21] Xu X, Li M, Deng Z, Jiang Z, Li D, Wang S, Hu C*. cGASa and cGASb from grass carp (Ctenopharyngodon idellus) play opposite roles in mediating type I interferon response. Developmental and Comparative Immunology, 2021, 125, 104233.
[22] Lu S, Peng X, Lin G, Xu K, Wang S, Qiu W, Du H, Chang K, Lv Y, Liu Y, Deng H, Hu C, Xu X*. Grass carp (Ctenopharyngodon idellus) SHP2 suppresses IFN I expression via decreasing the phosphorylation of GSK3β in a non-contact manner. Fish and Shellfish Immunology. 2021, 116: 150-160.
[23] Xu X, Li M, Wu C, Li D, Jiang Z, Liu C, Cheng B, Mao H, Hu C. The Fish-Specific Protein Kinase (PKZ) Initiates Innate Immune Responses via IRF3- and ISGF3-Like Mediated Pathways. Frontiers in Immunology. 2019, 10, 582.
[24] Xu X, Li M, Li D, Jiang Z, Liu C, Shi X, Wu C, Chen X, Lin G, Hu C* Identification of the SAMHD1 gene in grass carp and its roles in inducing appotosis and inhibiting GCRV proliferation. Fish & Shellfish Immunology, 2019, 88: 606-618.