第一及通讯作者文章

2026

1.       Yun Zhang, Jiarui Zhang, Shengan Li, Zhihong Shi, Lingzhen Liu, Xianlin Bian, Qiquan Wang*, Wenhui Li*, and Yang Xiang*. "Amphibian Βγ-Cat Defines a Pore-Forming Protein System for Nutrient Acquisition and Metabolic Flexibility." Zoological Research  (2026).

2.       Qiquan Wang, Jian Li, Mengqi Yang, Caifen Guo, Ming Zhang, Chunping Huang, Xiang Wang, Dongqin Zhang, Lin Zeng, Hao Ke, Yunling Wen, Sheng’an Li, Wenhui Lee, Limin Zhao, Xinqiang Lan*, and Yang Xiang*. "Peptide Oh‐Cath30 Mitigates Cachexia‐Induced Muscle Atrophy Via Modulation of Tlr4‐Associated Inflammation." Journal of Cachexia, Sarcopenia and Muscle 17, no. 1 (2026): e70195.

3.       Jian Li, Xinqiang Lan, Caifen Guo, Xiang Wang, Chunping Huang, Lin Zeng, Xiaoli Tian, Yang Xiang*, and Qiquan Wang*. "Comprehensive Multi-Ptm Profiling Reveals Age-Associated Remodeling in Skeletal Muscle." Zoological Research  (2026).

4.       Caifen Guo, Xinqiang Lan, Chunping Huang, Xiang Wang, Dongqin Zhang, Lin Zeng, Qiquan Wang, Yang Xiang*, and Jian Li*. "Muscle-Specific Transcriptomic and Metabolomic Signatures Reveal Heterogeneous Aging Trajectories and Altered Intercellular Communication in Male Murine Skeletal Muscle." Biogerontology 27, no. 2 (2026): 48.

5.       Leilei Cui, Chunping Huang, Yu Su, Shiqi Xu, Liang Zha, Qiuyuan Zhao, Quan Wu, Xinqiang Lan, Yang Xiang* and Qiquan Wang*. "Comprehensive Proteomics and Β-Hydroxybutyrylation Profiling in Starvation-Induced Gastrocnemius Muscle Remodeling." Biology 15, no. 3 (2026): 289.

2025

6.       Qiquan Wang, Meng Yao, Xiang Wang, Xinqiang Lan, Gailing Fan, and Yang Xiang*. "From Liver to Muscle: Crosstalk Mechanisms and Interventions in Sarcopenia." Health and Metabolism 2, no. 3 (2025): 7.

7.       Yan Liu, Qiquan Wang, Tiane Huang, Meng Yao, Benhui Wang, Chunping Huang, Shu Wang, Yifan Lu, Xinqiang Lan, Xiaoli Tian*, Yang Xiang*. Aldehyde Oxidase 1 Deficiency Enhances Aerobic Exercise Performance by Promoting Skeletal Muscle Adaptation and Improving Mitochondrial Function. FASEB J. 2025 Jul 31;39(14):e70815. doi: 10.1096/fj.202500240R

8.       Xinqiang Lan, Mengqi Yang, Jiali Wang, Chunping Huang, Andong Wu, Leilei Cui, Yingqi Guo, Lin Zeng, Xiaoling Guo, Yun Zhang, Yang Xiang*, Qiquan Wang*. Pore-Forming Protein LIN-24 Enhances Starvation Resilience in Caenorhabditis elegans by Modulating Lipid Metabolism and Mitochondrial Dynamics. Toxins (Basel). 2025 Feb 6;17(2):72.

2024

9.       Qiquan Wang, Xinqiang Lan, Hao Ke, Siman Xu, Chunping Huang, Jiali Wang, Xiang Wang, Tiane Huang, Xia Wu, Mengxin Chen, Lin Zeng, Xiaoli Tian, Yang Xiang*. Histone β‐hydroxybutyrylation is critical in reversal of sarcopenia. Aging Cell. 2024:e14284. (WOS:001279242900001)

10.    Wanli Xiao, Tiane Huang, Jing Zhou, Benhui Wang, Xiang Wang, Weirong Zeng, Qiquan Wang, Xinqiang Lan, Yang Xiang*. Inhibition of MAT2A Impairs Skeletal Muscle Repair Function. Biomolecules. 2024;14(9):1098. (PMID: 39334864)

11.    Xinqiang Lan, Chengjie Deng, Qiquan Wang, Limin Zhao, Baowei Jiao, Yang Xiang. The Role of TGF-β Signaling in Muscle Atrophy, Sarcopenia and Cancer Cachexia. General and Comparative Endocrinology. 2024:114513. (WOS:001242452400001)

2023

12.    Huijie Zhang#, Benhui Wang#, Xiang Wang#, Chunping Huang#, Siman Xu, Jiali Wang, Tiane Huang, Wanli Xiao, Xiaoli Tian, Xinqiang Lan*, Qiquan Wang* & Yang Xiang*, Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation, Journal of Cachexia, Sarcopenia and Muscle 2023 15 (1), 173-188. (WOS:001109770000001)

13.    Huijie Zhang, Weirong Zeng, Mingming Zhao, Jiali Wang, Qiquan Wang, Ting Chen, Yuyan Zhang, Wenhui Lee, Shenghan Chen, Yun Zhang*, Xinqiang Lan*, Yang Xiang*, Caenorhabditis elegans LIN‐24, a homolog of bacterial pore‐forming toxin, protects the host from microbial infection. The FASEB Journal. 2023 Oct;37(10):e23162. DOI:10.1096/fj.202300063R. (MEDLINE:37682220) (WOS:001070053100001)

14.    Tiane Huang, Jing Zhou, Benhui Wang, Xiang Wang, Wanli Xiao, Mengqi Yang, Yan Liu, Qiquan Wang, Yang Xiang#, Xinqiang Lan#. Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation. Int. J. Mol. Sci. 2024, 25, 95. (WOS:001140712300001)

15.    Qiquan Wang, Xinqiang Lan, Xuesong Wei, Siman Xu, Lingzhen Liu, Xianling Bian, Lin Zeng, Xiaolong Guo, Yingqi Guo, Wenhui Lee, Yang Xiang*, Yun Zhang*. Amphibian pore-forming protein βγ-CAT drives metabolite release from small extracellular vesicles through channel formation. Zoological Research, 2023, 44(4): 739-742. doi: 10.24272/j.issn.2095-8137.2022.510 (WOS:001043377400011)

16.    Yang Xiang*, Qiquan Wang, Xinqiang Lan, Huijie Zhang, Daixu Wei*. Function and treatment strategies of β-hydroxybutyrate in aging. Smart Materials in Medicine. 2023;4:160-72.

17.    Lingzhen Liu, Long Liu, Zhihong Shi, Xianling Bian, Ziru Si, Qiquan Wang, Yang Xiang*, Yun Zhang*. Amphibian pore-forming protein βγ-CAT drives extracellular nutrient scavenging under cell nutrient deficiency. Iscience. 2023;26(5). (WOS:001001126800001)

2022

18.    Huijie Zhang, Jiawei Qin, Xinqiang Lan, Weirong Zeng, Jing Zhou, Tiane Huang, Wanli Xiao, Qiquan Wang, Sujiao Sun, Weiting Su, Wenhui Nie, Shan Yang, Ji Yang, Qian Gao, Yang Xiang*. Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function. Biogerontology, 2022, 23 (1), 115-128. doi: 10.1007/s10522-022-09950-5. Epub ahead of print. PMID: 35038074. (WOS:000743394500001)

2020

19.    Ji Yang, Huijie Zhang, Sujiao Sun, Xue Wang, Ying Guan, Qili Mi, Wanli Zeng, Haiying Xiang, Huadong Zhu, Xin Zou, Yang Xiang*, Qian Gao*. Autophagy and Hsp70 activation alleviate oral epithelial cell death induced by food-derived hypertonicity. Cell Stress and Chaperones. 2020;25(2):253-64. (WOS:000518492000007)

2019

20.    Yang Xiang, Mingming Zhao, Yun Zhang (2019). "Pore-forming toxin-like proteins link lysosomal function and cellular metabolism." Toxicon 158: S13. (WOS:000565208400045)

21.    Mingming Zhao, Zhihong Shi, Wenhui Lee, Yang Xiang, Yun Zhang (2019). "The physiological function of aerolysin-like protein Lin-24 in Caenorhabditis elegans." Toxicon 158: S87-S88. (WOS:000565208400292)

2018

22.    Yang Xiang*, Mingming Zhao, Sujiao Sun, Xiaolong Guo, Qiquan Wang, Shengan Li, Wenhui Lee, Yun Zhang*. A high concentration of DMSO activates caspase-1 by increasing the cell membrane permeability of potassium. Cytotechnology. 2018;70(1):313-20. (WOS:000424885900028)

2016

23.    Sujiao Sun, Ping Jiang, Weiting Su, Yang Xiang*, Jian Li, Lin Zeng, Shuangjuan Yang. Wild chrysanthemum extract prevents UVB radiation-induced acute cell death and photoaging. Cytotechnology. 2016;68(2):229-40.

2015

24.    Guoyu Yu, Ping Jiang, Yang Xiang*, Yong Zhang, Zhu Zhu, Chuanrao Zhang, Siman Lee, Wenhui Lee, Yun Zhang*. Increased expression of protease-activated receptor 4 and trefoil factor 2 in human colorectal cancer. PLoS One. 2015;10(4):e0122678.

25.    Youming Lei, Yunfen Zu, Jiying Wang, Song Bai, Yunfei Shi, Rou Shi, Jin Duan, Daolei Cui, Jianlan Chen, Yang Xiang*, Jian Dong*. Interleukin-1β-mediated suppression of microRNA-101 and upregulation of enhancer of zeste homolog 2 is involved in particle-induced lung cancer. Medical Oncology. 2015;32(1):387.

2014

26.    Yang Xiang, Chao Yan, Xiaolong Guo, Kaifeng Zhou, Qian Gao, Xuan Wang, Feng Zhao, Jie Liu, Wenhui Lee, Yun Zhang. Host-derived, pore-forming toxin–like protein and trefoil factor complex protects the host against microbial infection. Proceedings of the National Academy of Sciences. 2014;111(18):6702-7. (当期封面文章，被Nature Reviews Microbiology和Aging Research Reviews正面引用)

27.    Yanjie Wang, Xiaolong Guo, Shengan Li, Yuqi Zhao, Zichao Liu, Wenhui Lee, Yang Xiang*, Yun Zhang*. Prohibitin is involved in the activated internalization and degradation of protease-activated receptor 1. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2014;1843(7):1393-401.

28.    Feng Zhao, Chao Yan, Xuan Wang, Yang Yang, Guangyin Wang, Wenhui Lee, Yang Xiang*, Yun Zhang*. Comprehensive transcriptome profiling and functional analysis of the frog (Bombina maxima) immune system. DNA research. 2014;21(1):1-13.

2013

29.    Yang Xiang, Xuan Wang, Chao Yan, Qian Gao, Shengan Li, Jie Liu, Kaifeng Zhou, Xiaolong Guo, Wenhui Lee, Yun Zhang. Adenosine-5'-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome. PLoS One. 2013;8(5):e63759.

2012

30.    Yang Xiang, Qian Gao, Weiting Su, Lin Zeng, Jinhuan Wang, Yi Hu, Wenhui Nie, Xutong Ma, Yong Zhang, Wenhui Lee, Yun Zhang. Establishment, characterization and immortalization of a fibroblast cell line from the Chinese red belly toad Bombina maxima skin. Cytotechnology. 2012;64(1):95-105.

参与发表文章

2026

1.       Donghai Lin, Qiu X, Wang Y, Yang Xiang, Caihua Huang. Redox coupling of lactate and β-hydroxybutyrate: An inter-organ circuit linking metabolic flexibility, mitochondrial adaptation, and disease. Redox Biology. 2026:104279.

2025

2.       Runzhou Yang, Yiting Wang, Zhuanbin Wu, Yun Luo, Diandian Wang, Yun Zou, Youzhi Liang, Jiakang Li, Su Zhang, Chunping Huang, Weirong Zeng, Siyuan Chang, Senmiao Li, Xiaoyan Meng, Huifang Sun, Peipei Liu, Jinzhi Lei, Yang Xiang, Yu Gu, Biao Yan, Shiqing Cai, Jiayi Zhang, Jiansheng Kang. Ambient light alleviates retinal neurodegeneration in mice by powering mitochondria via the engineered optoenergetic rhodopsin. Signal Transduction and Targeted Therapy. 2025;10(1):355.

3.       Ya Zhao, Jiayu Qiu, Fang Wu, Xueting Gong, Weixin Lv, Jiankun Liu, Jiayi Dong, Xueer Li, Andong Wu, Jingjing Duan, Yang Xiang, Xiaoli Tian. Dietary Citrate Restores Age-Related Endothelial Cell Mitochondrial Dysfunction and Alleviates Atherosclerosis. Aging Cell. 2025 Sep 4:e70213. doi: 10.1111/acel.70213. Epub ahead of print. PMID: 40905413.

2024

4.       Zhenping Yu, Andong Wu, Hao Ke, Jiankun Liu, Ya Zhao, Yuanzheng Zhu, Xiaoyu Wang, Yang Xiang, Hongbo Xin, Xiaoli Tian. Age-Disturbed Vascular Extracellular Matrix Links to Abdominal Aortic Aneurysms. J Gerontol A Biol Sci Med Sci. 2024 Nov 1;79(11):glae201.

2023

5.       Qingqing Ye, Qiquan Wang, Wenhui Lee, Yang Xiang, Jixue Yuan, Yun Zhang, Xiaolong Guo. A Pore Forming Toxin-like Protein Derived from Chinese Red Belly Toad Bombina maxima Triggers the Pyroptosis of Hippomal Neural Cells and Impairs the Cognitive Ability of Mice. Toxins. 2023;15(3):191.

6.       Yi Duan, Yang Xiang, Jimin Chu, Xianghong Lin, Miao He, Chenggui Zhang, Sujiao Sun, Ling Huang. Handelin Reduces Ultraviolet A-Induced Photoaging by Inhibiting Reactive Oxygen Species Generation and Enhancing Autophagy. The Tohoku Journal of Experimental Medicine. 2023;259(3):189-98. (WOS:000993309000003)

7.       Jimin Chu, Yang Xiang, Xianghong Lin, Miao He, Yan Wang, Qiong Ma, Jingxian Duan, Sunjiao Sun. Handelin protects human skin keratinocytes against ultraviolet B-induced photodamage via autophagy activation by regulating the AMPK-mTOR signaling pathway. Archives of Biochemistry and Biophysics. 2023:109646. (WOS:001013011200001)

2022

8.       Changkun Long, Hongfei Liu, Wenxing Zhan, Liping Chen, Zhenping Yu, Shane Tian, Yang Xiang, Shenghan Chen, Xiaoli Tian. Chronological attenuation of NPRA/PKG/AMPK signaling promotes vascular aging and elevates blood pressure. Aging cell. 2022:e13699. (WOS:000844435100001)

2020

9.       Qiquan Wang, Xianling Bian, Lin Zeng, Fei Pan, Lingzhen Liu, Jinyang Liang, Lingyan Wang, Kaifeng Zhou, Wenhui Lee, Yang Xiang, Yun Zhang. A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions. Journal of Biological Chemistry. 2020;295(30):10293-306. (WOS:000556713400016)

2019

10.    Abdul Haseeb Khan, Zhiwen Zou, Yang Xiang, Shenghan Chen, Xiaoli Tian. Conserved signaling pathways genetically associated with longevity across the species. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2019;1865(7):1745-55. (WOS:000470042800003)

11.    Xiaolong Guo, Lingzhen Liu, Qiquan Wang, Jinyang Liang, Wenhui Lee, Yang Xiang, Shengan Li, Yun Zhang. Endogenous pore-forming protein complex targets acidic glycosphingolipids in lipid rafts to initiate endolysosome regulation. Communications biology. 2019;2(1):1-13. (WOS:000461154000002)

2018

12.    Feng Zhao, Xinqiang Lan, Tao Li, Yang Xiang, Fang Zhao, Yun Zhang, Wenhui Lee. Proteotranscriptomic analysis and discovery of the profile and diversity of toxin-like proteins in centipede. Molecular & Cellular Proteomics. 2018;17(4):709-20.

2017

13.    Shengan Li, Long Liu, Xiaolong Guo, Yuyan Zhang, Yang Xiang, Qiquan Wang, Wenhui Lee, Yun Zhang. Host pore-forming protein complex neutralizes the acidification of endocytic organelles to counteract intracellular pathogens. The Journal of infectious diseases. 2017;215(11):1753-63.

2014

14.    Siman Li, Ping Jiang, Yang Xiang, Weiwei Wang, Yuechun Zhu, Weiyang Feng, Shude Li, Guoyu Yu. Protease-activated receptor (PAR) 1, PAR2 and PAR4 expressions in esophageal squamous cell carcinoma. Zoological Research. 2014;35(5):420.

15.    Shengan Li, Jie Liu, Yang Xiang, Yanjie Wang, Wenhui Lee, Yun Zhang. Therapeutic potential of the antimicrobial peptide OH-CATH30 for antibiotic-resistant Pseudomonas aeruginosa keratitis. Antimicrobial agents and chemotherapy. 2014;58(6):3144-50.

16.    Shengan Li, Jie Liu, Yang Xiang, Yanjie Wang, Wenhui Lee, Yun Zhang. The antimicrobial peptide OH-CATH30 as a potential therapy for antibiotic-resistant Pseudomonas aeruginosa keratitis. Antimicrobial Agents and Chemotherapy. 2014.

2013

17.    Shengan Li, Yang Xiang, Yanjie Wang, Jie Liu, Wenhui Lee, Yun Zhang. Naturally occurring antimicrobial peptide OH-CATH30 selectively regulates the innate immune response to protect against sepsis. Journal of medicinal chemistry. 2013;56(22):9136-45.

18.    Ping Jiang, Guoyu Yu, Yong Zhang, Yang Xiang, Hairong Hua, Li Bian, Chunyan Wang, Wenhui Lee, Yun Zhang. Down-regulation of protease-activated receptor 4 in lung adenocarcinoma is associated with a more aggressive phenotype. Asian Pacific Journal of Cancer Prevention. 2013;14(6):3793-8.

19.    Ping Jiang, Yang Xiang, Yanjie Wang, Siman Li, Yan Wang, Hairong Hua, Guoyu Yu, Yong Zhang, Wenhui Lee, Yun Zhang. Differential expression and subcellular localization of Prohibitin 1 are related to tumorigenesis and progression of non-small cell lung cancer. International journal of clinical and experimental pathology. 2013;6(10):2092.

20.    Tingyi Du, Huiming Luo, Haichun Qin, Fang Wang, Qing Wang, Yang Xiang, Yun Zhang. Circulating serum trefoil factor 3 (TFF3) is dramatically increased in chronic kidney disease. PloS one. 2013;8(11):e80271.

2012

21.    Yong Zhang, Yanjie Wang, Yang Xiang, Wenhui Lee, Yun Zhang. Prohibitins are involved in protease‐activated receptor 1‐mediated platelet aggregation. Journal of Thrombosis and Haemostasis. 2012;10(3):411-8.

2011

22.    Yong Zhang, Guoyu Yu, Yanjie Wang, Yang Xiang, Qian Gao, Ping Jiang, Jie Zhang, Wenhui Lee, Yun Zhang. Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2. Cellular and molecular life sciences. 2011;68(22):3771-80.

23.    Yong Zhang, Guoyu Yu, Ping Jiang, Yang Xiang, Wenliang Li, Wenhui Lee, Yun Zhang. Decreased expression of protease-activated receptor 4 in human gastric cancer. The international journal of biochemistry & cell biology. 2011;43(9):1277-83.

24.    Qian Gao, Yang Xiang, Lin Zeng, Xutong Ma, Wenhui Lee, Yun Zhang. Characterization of the βγ-crystallin domains of βγ-CAT, a non-lens βγ-crystallin and trefoil factor complex, from the skin of the toad Bombina maxima. Biochimie. 2011;93(10):1865-72.

25.    Qian Gao, Yang Xiang, Zhongming Chen, Lin Zeng, Xutong Ma, Yun Zhang. βγ-CAT, a non-lens betagamma-crystallin and trefoil factor complex, induces calcium-dependent platelet apoptosis. Thrombosis and haemostasis. 2011;105(05):846-54.

2010

26.    Yong Zhang, Guoyu Yu, Yang Xiang, Jianbo Wu, Ping Jiang, Wenhui Lee, Yun Zhang. Bm-TFF2, a toad trefoil factor, promotes cell migration, survival and wound healing. Biochemical and biophysical research communications. 2010;398(3):559-64.

27.    Guoyu Yu, Yong Zhang, Yang Xiang, Ping Jiang, Zhongming Chen, Wenhui Lee, Yun Zhang*. Cell migration-promoting and apoptosis-inhibiting activities of Bm-TFF2 require distinct structure basis. Biochemical and biophysical research communications. 2010;400(4):724-8.