研究方向：

衰老的代谢控制及肌少症

主要荣誉及专业团队任职：

l  中国老年医学会基础与转化分会常务委员及副秘书长

l  中国生理学会衰老与健康专业委员会委员及秘书

l  中华预防医学会老年病预防与控制专业委员会委员

l  中国生物物理学会代谢生物学分会青年理事

l  江西省生物化学与分子生物学学会理事

l  江西省细胞生物学学会理事

教育经历：

1、2005/09——2011/07，中国科学院，昆明动物研究所，博士研究生/博士

2、2001/09——2005/07，武汉大学，生命科学学院生物技术系，本科/学士

工作经历：

1、2016/05至今, 南昌大学，教授

2、2015/01—2017/04,中国科学院，昆明动物研究所，副研究员

3、2012/03—2014/12,中国科学院，昆明动物研究所，助理研究员

4、2011/07—2012/02，中国科学院，昆明动物研究所，研究实习员

执教课程：

本科生课程：《生物化学》

研究生课程：《分子细胞生物学》（双语）

主持课题项目：

1.     跨物种/多组学发掘肌少症临床干预新分子，南昌大学学科交叉创新项目，50万元，2025.01-2027.12

2.     β-羟基丁酸修饰HSP70改善肌少症的机制，国家自然科学基金面上项目，项目编号82471591，直接经费49万元，2025.01-2028.12。

3.     组织器官衰老顺序影响个体亚健康及疾病的机制，科技部重点研发计划，项目编号：2023YFC3603301（课题一骨干、子课题负责人，课题负责人田小利），105万元，2023.12-2026.11.

4.     营养不良抵抗因子延缓肌少症的机制，江西省重点项目，项目编号：20242BAB26156，20万元，2024.09-2026.08.

5.     运动-营养改善代谢稳态、延缓衰老、促进健康的机制，科技部重点研发计划，项目编号2020YFC2002903（子课题负责人，项目协调人），支配经费108万元，2020.06-2023.06.

6.     江西省杰出青年人才资助计划，项目编号20192BCB23003，资助金额30万元，2019.01-2022.12。

7.     抑素蛋白和凝血酶受体协同调节内皮细胞衰老的机制，国家自然科学基金面上项目，项目编号81873814，直接经费61万元，2019.01-2022.12。

8.     肠道菌群孔道形成毒素通过调控线粒体功能影响脂代谢的机制研究，江西省杰出青年基金项目（青年重点项目），项目编号2018ACB21036，经费20万元，2018.01-2021.12

9.     肠道菌群孔道形成毒素与三叶因子复合物在血管内皮衰老中的作用机制研究，国家自然科学基金重大研究计划培育项目，项目编号91649120，直接经费60万元，2017.01-2019.12。

10.  滇产野菊花防治皮肤光损伤的有效成分分离及机制研究，遗传资源与进化国家重点实验室开放基金，项目编号GREKF18-10，资助金额7万元，2018年6月至2021年5月。

11.  两栖动物孔道形成毒素类似蛋白在抗感染免疫中的作用，中国科学院西部之光人才一般项目，资助金额30万元。2015.01-2017.12

12.  斑马鱼aerolysin毒素类似蛋白zebralysin在抗感染免疫中的作用，云南省自然科学基金一般项目，项目编号2014FB175，资助金额：10万元。2015.01-2017.12

13.  非晶状体晶状体蛋白与三叶因子复合物在大蹼铃蟾抗感染免疫中的作用研究，国家自然科学基金青年基金，项目编号31301884，资助金额：24万元，2014.01-2016.12。

发表论文

https://pubmed.ncbi.nlm.nih.gov/?term=yang+xiang+nanchang+university&sort=date

2025

1.        Liu Y, Wang QQ, Huang TE, Yao M, Wang BH, Huang CP, Wang S, Lu YF, Lan XQ, Tian XL, Xiang Y*. Aldehyde Oxidase 1 Deficiency Enhances Aerobic Exercise Performance by Promoting Skeletal Muscle Adaptation and Improving Mitochondrial Function. FASEB J. 2025 Jul 31;39(14):e70815. doi: 10.1096/fj.202500240R

2.        Lan Xinqiang, Mengqi Yang, Jiali Wang, Chunping Huang, Andong Wu, Leilei Cui, Yingqi Guo, Lin Zeng, Xiaoling Guo, Yun Zhang, Yang Xiang *, Qiquan Wang*. Pore-Forming Protein LIN-24 Enhances Starvation Resilience in Caenorhabditis elegans by Modulating Lipid Metabolism and Mitochondrial Dynamics. Toxins (Basel). 2025 Feb 6;17(2):72.

2024

3.        Wang Qiquan, Xinqiang Lan, Hao Ke, Siman Xu, Chunping Huang, Jiali Wang, Xiang Wang, Tiane Huang, Xia Wu, Mengxin Chen, Lin Zeng, Xiao-Li Tian, Yang Xiang*. Histone β‐hydroxybutyrylation is critical in reversal of sarcopenia. Aging Cell. 2024:e14284. (WOS:001279242900001)

4.        Xiao Wanli, Tian-E Huang, Jing Zhou, Benhui Wang, Xiang Wang, Weirong Zeng, Qiquan Wang, Xinqiang Lan, Yang Xiang*. Inhibition of MAT2A Impairs Skeletal Muscle Repair Function. Biomolecules. 2024;14(9):1098. (PMID: 39334864)

5.        Lan Xin-Qiang, Cheng-Jie Deng, Qi-Quan Wang, Li-Min Zhao, Bao-Wei Jiao, Yang Xiang. The Role of TGF-β Signaling in Muscle Atrophy, Sarcopenia and Cancer Cachexia. General and Comparative Endocrinology. 2024:114513. (WOS:001242452400001)

2023

6.        Hui-Jie Zhang#, Ben-Hui Wang#, Xiang Wang#, Chun-Ping Huang#, Si-Man Xu, Jia-Li Wang, Tian-E Huang, Wan-Li Xiao, Xiao-Li Tian, Xin-Qiang Lan*, Qi-Quan Wang* & Yang Xiang*, Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation, Journal of Cachexia, Sarcopenia and Muscle 2023 15 (1), 173-188. (WOS:001109770000001)

7.        Huijie Zhang, Weirong Zeng, Ming-ming Zhao, Jiali Wang, Qiquan Wang, Ting Chen, Yuyan Zhang, Wenhui Lee, Shenghan Chen, Yun Zhang*, Xinqiang Lan*, Yang Xiang*, Caenorhabditis elegans LIN‐24, a homolog of bacterial pore‐forming toxin, protects the host from microbial infection. The FASEB Journal. 2023 Oct;37(10):e23162. DOI:10.1096/fj.202300063R. (MEDLINE:37682220) (WOS:001070053100001)

8.        Huang, T.; Zhou, J.; Wang, B.; Wang, X.; Xiao, W.; Yang, M.; Liu, Y.; Wang, Q.; Xiang, Y.#; Lan, X#. Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation. Int. J. Mol. Sci. 2024, 25, 95. (WOS:001140712300001)

9.        Qi-Quan Wang, Xin-Qiang Lan, Xue-Song Wei, Si-Man Xu, Ling-Zhen Liu, Xian-Ling Bian, Lin Zeng, Xiao-Long Guo, Ying-Qi Guo, Wen-Hui Lee, Yang Xiang*, Yun Zhang*. Amphibian pore-forming protein βγ-CAT drives metabolite release from small extracellular vesicles through channel formation. Zoological Research, 2023, 44(4): 739-742. doi: 10.24272/j.issn.2095-8137.2022.510 (WOS:001043377400011)

10.    Yang Xiang*, Qi-Quan Wang, Xin-Qiang Lan, Hui-Jie Zhang, Dai-Xu Wei*. Function and treatment strategies of β-hydroxybutyrate in aging. Smart Materials in Medicine. 2023;4:160-72.

11.    Liu Ling-Zhen, Long Liu, Zhi-Hong Shi, Xian-Ling Bian, Zi-Ru Si, Qi-Quan Wang, Yang Xiang*, Yun Zhang*. Amphibian pore-forming protein βγ-CAT drives extracellular nutrient scavenging under cell nutrient deficiency. Iscience. 2023;26(5). (WOS:001001126800001)

2022

12.    Zhang H, Qin J, Lan X, Zeng W, Zhou J, Huang TE, Xiao WL, Wang QQ, Sun S, Su W, Nie W, Yang S, Yang J, Gao Q, Xiang Y*. Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function. Biogerontology, 2022, 23 (1), 115-128. doi: 10.1007/s10522-022-09950-5. Epub ahead of print. PMID: 35038074. (WOS:000743394500001)

2020

13.    Yang Ji, Huijie Zhang, Sujiao Sun, Xue Wang, Ying Guan, Qili Mi, Wanli Zeng, Haiying Xiang, Huadong Zhu, Xin Zou, Yang Xiang*, Qian Gao*. Autophagy and Hsp70 activation alleviate oral epithelial cell death induced by food-derived hypertonicity. Cell Stress and Chaperones. 2020;25(2):253-64. (WOS:000518492000007)

2019

14.    Xiang, Y., M. Zhao and Y. Zhang (2019). "Pore-forming toxin-like proteins link lysosomal function and cellular metabolism." Toxicon 158: S13. (WOS:000565208400045)

15.    Zhao, M.-M., Z.-H. Shi, W.-H. Lee, Y. Xiang and Y. Zhang (2019). "The physiological function of aerolysin-like protein Lin-24 in Caenorhabditis elegans." Toxicon 158: S87-S88. (WOS:000565208400292)

2018

16.    Xiang Yang*, Ming-ming Zhao, Sujiao Sun, Xiao-Long Guo, Qiquan Wang, Sheng-An Li, Wen-Hui Lee, Yun Zhang*. A high concentration of DMSO activates caspase-1 by increasing the cell membrane permeability of potassium. Cytotechnology. 2018;70(1):313-20. (WOS:000424885900028)

2016

17.    Sun Sujiao, Ping Jiang, Weiting Su, Yang Xiang*, Jian Li, Lin Zeng, Shuangjuan Yang. Wild chrysanthemum extract prevents UVB radiation-induced acute cell death and photoaging. Cytotechnology. 2016;68(2):229-40.

2015

18.    Yu Guoyu, Ping Jiang, Yang Xiang*, Yong Zhang, Zhu Zhu, Chuanrao Zhang, Siman Lee, Wenhui Lee, Yun Zhang*. Increased expression of protease-activated receptor 4 and trefoil factor 2 in human colorectal cancer. PLoS One. 2015;10(4):e0122678.

19.    Lei You-Ming, Yun-Fen Zu, Jiying Wang, Song Bai, Yun-Fei Shi, Rou Shi, Jin Duan, Daolei Cui, Jianlan Chen, Yang Xiang*, Jian Dong*. Interleukin-1β-mediated suppression of microRNA-101 and upregulation of enhancer of zeste homolog 2 is involved in particle-induced lung cancer. Medical Oncology. 2015;32(1):387.

2014

20.    Xiang Yang, Chao Yan, Xiaolong Guo, Kaifeng Zhou, Qian Gao, Xuan Wang, Feng Zhao, Jie Liu, Wen-Hui Lee, Yun Zhang. Host-derived, pore-forming toxin–like protein and trefoil factor complex protects the host against microbial infection. Proceedings of the National Academy of Sciences. 2014;111(18):6702-7. (当期封面文章，被Nature Reviews Microbiology和Aging Research Reviews正面引用)

21.    Wang Yan-Jie, Xiao-Long Guo, Sheng-An Li, Yu-Qi Zhao, Zi-Chao Liu, Wen-Hui Lee, Yang Xiang*, Yun Zhang*. Prohibitin is involved in the activated internalization and degradation of protease-activated receptor 1. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2014;1843(7):1393-401.

22.    Zhao Feng, Chao Yan, Xuan Wang, Yang Yang, Guangyin Wang, Wenhui Lee, Yang Xiang*, Yun Zhang*. Comprehensive transcriptome profiling and functional analysis of the frog (Bombina maxima) immune system. DNA research. 2014;21(1):1-13.

2013

23.    Xiang Yang, Xuan Wang, Chao Yan, Qian Gao, Sheng-An Li, Jie Liu, Kaifeng Zhou, Xiaolong Guo, Wenhui Lee, Yun Zhang. Adenosine-5'-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome. PLoS One. 2013;8(5):e63759.

2012

24.    Xiang Yang, Qian Gao, Weiting Su, Lin Zeng, Jinhuan Wang, Yi Hu, Wenhui Nie, Xutong Ma, Yong Zhang, Wenhui Lee, Yun Zhang. Establishment, characterization and immortalization of a fibroblast cell line from the Chinese red belly toad Bombina maxima skin. Cytotechnology. 2012;64(1):95-105.