Research Projects

1. Pore-Forming Protein MPEG1 Ameliorates Sarcopenia via "Proteolytic Degradation Reprogramming"
   National Natural Science Foundation of China (Regional Science Fund Project) | RMB 320,000
   January 2025 – December 2028 | Role: Principal Investigator | Status: Active

2. Mechanistic Study on UBL3 β-Hydroxybutyrylation Modification in Ameliorating Sarcopenia
   Jiangxi Provincial Natural Science Foundation (General Project) | RMB 100,000
   June 2025 – May 2028 | Role: Principal Investigator | Status: Active

3. Development of a Drug-Induced Aging Mouse Model
   Industry-Academia Collaboration Project (Hunan Hongshunkang Biotechnology Co., Ltd.) | RMB 330,000
   May 2024 – December 2024 | Role: Project Leader | Status: Completed

Publications:

Corresponding Author and First Author Articles:

1. Wang Q^#, Li J^#, Yang M^#, Guo C^#, Zhang M, Huang C, Wang X, Zhang D, Zeng L, Ke H, Wen Y, Li S, Lee W, Zhao L, Lan X*, Xiang Y*. (2026) Peptide OH-CATH30 Mitigates Cachexia-Induced Muscle Atrophy via Modulation of TLR4-Associated Inflammation. J Cachexia Sarcopenia Muscle. Feb;17(1):e70195.

2.Guo, CF#., Lan, XQ#., Huang, CP#., Wang, X., Zhang, DQ., Zeng, L., Wang, QQ*., Xiang Y*., Li J*. Muscle-specific transcriptomic and metabolomic signatures reveal heterogeneous aging trajectories and altered intercellular communication in male murine skeletal muscle. Biogerontology. 2026. (in press). 

3. Li, Jian#., Lan, XQ#., Guo, CF#., Wang, X #., Huang, CP., Zhang, DQ., Zeng, L., Tian, XL., Xiang, Y*., Wang, QQ*. Comprehensive Multi-PTM profiling reveals age-associated remodeling in skeletal muscle. Zoological Research. 2026. (in press). 

4. Cui, L., Huang, C., Su, Y., Xu, S., Zha, L., Zhao, Q., Quan, W., Lan, X., Xiang, Y*., Wang, Q*. (2026). Comprehensive Proteomics and β-Hydroxybutyrylation Profiling in Starvation-Induced Gastrocnemius Muscle Remodeling. Biology (Basel). 2026 Feb 6;15(3):289.

5. Lan, X^#., Yang, M^#., Wang, J^#., Huang,C., Wu, A., Cui, L., Guo, Y.., Zeng, L., Guo, X., Zhang, Y., Xiang, Y^*., Wang, Q^*. (2025) Pore-Forming Protein LIN-24 Enhances Starvation Resilience in Caenorhabditis elegans by Modulating Lipid Metabolism and Mitochondrial Dynamics. 17, (2025):72. Toxins.

6. Liu, Y^#., Wang, Q-Q^#., Huang, T-E^#., Yao, M., Wang, B-H., Huang, C-P., Wang, S., Lu, Y-F., Lan, X-Q., Tian, X-L*. and Xiang, Y*. (2025). Aldehyde Oxidase 1 Deficiency Enhances Aerobic Exercise Performance by Promoting Skeletal Muscle Adaptation and Improving Mitochondrial Function. The FASEB Journal, 39(14), p.e70815.

7. Wang, Q^#., Yao, M^#., Wang, X^#., Lan, X., Fan, G. and Xiang, Y*. (2025). From Liver to Muscle: Crosstalk Mechanisms and Interventions in Sarcopenia. Health and Metabolism.

8. Wang, QQ^#., Lan, XQ^#., Ke H^#., Xu, SM^#., Huang, CP^#., Wang, JL., Huang, TE., Tian, XL., Xiang, Y^*. (2024). Histone β-hydroxybutyrylation is critical in reversal of sarcopenia. Aging cell. 30:e14284.

9. Zhang, HJ^#., Wang, BH^#., Wang, X^#., Huang, CP^#., Xu, SM., Wang, JL., Huang, TE., Xiao, WL., Tian, XL., Lan, XQ^*., Wang, QQ^*., Xiang Y^*.(2023) Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation. 15, 173-188. Journal of cachexia, sarcopenia and muscle.

10. Wang, Q.Q^#., Bian, X.L^#., Zeng, L^#., Pan, F., Liu, L.L., Liang, J.Y., Wang, L.Y., Zhou, K.F., Lee, W.H., Xiang, Y., et al. (2020). A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions. Journal of biological chemistry 295, 10293-10306.

11. Wei, XS^#., Liu, LZ., Zhang, Y., Wang, Q.Q^*. (2022) Protein composition of extracellular vesicles from the skin secretions of amphibian Bombina maxima. Zoological research 43, 687-690.

12. Wang, Q.Q^*#. Lan, XQ^#., Wei, XS., Liu, LZ et al. (2023) Amphibian pore-forming protein βγ-CAT drives metabolites release from small extracellular vesicles through channel formation. Zoological research 44, 739-742.

13. Lan, X., Yang, M., Wang, J., Huang, C., Wu, A., Cui, L., ... & Wang, Q. Q*. (2025). Pore-Forming Protein LIN-24 Enhances Starvation Resilience in Caenorhabditis elegans by Modulating Lipid Metabolism and Mitochondrial Dynamics. Toxins, 17(2), 72.

14. Guo, X.L^#., Liu, L.Z^#., Wang, Q.Q^#., Liang, J.Y., Lee, W.H., Xiang, Y., Li, S.A., and Zhang, Y^*. (2019). Endogenous pore-forming protein complex targets acidic glycosphingolipids in lipid rafts to initiate endolysosome regulation. Communications biology 2, 59. 

15. Zhang, Y^*#., Wang, Q.Q^#., Zhao, Z^#., Deng, C.J^#. (2021) Animal secretory endolysosome channel discovery. Zoological research 42, 141-152. 

16. Xiang, Y., Wang, Q.Q. Lan, XQ., Zhang, HJ. (2022) Function and treatment strategies of β-hydroxybutyrate in aging. Smart Materials in Medicine 4, 160-172. 

17. Wang, Q.Q., Liu, L.Z., Zeng, L., Wang, L.Y., Lee, W.H., Li, S.A., ... and Zhang, Y. (2019). Aerolysin-like pore-forming protein of host immune systems is regulated by a non-oligomeric homologue. TOXICON-OXFORD 158, S85-S86.

Patents:

1. Application of OH-CATH30 in the Preparation of Pharmaceuticals for Treating Skeletal Muscle Atrophy
   Patent No.: ZL 2024 1 1813799.6
   Date of Grant: April 1, 2025
   Inventors: Wang Qiquan, Yang Mengqi, Li Jian, Xiang Yang, Lan Xinqiang, Cui Leilei, Su Yu

2. Application of YE6144 in the Preparation of Pharmaceuticals for Treating Breast Cancer-Induced Skeletal Muscle Atrophy
   Patent No.: ZL 2024 1 1774438.5
   Date of Grant: April 1, 2025
   Inventors: Lan Xinqiang, Yang Mengqi, Li Jian, Wang Qiquan, Xiang Yang, Cui Leilei, Su Yu

3. Construction Method and Application of an Aldehyde Oxidase Aox1 Gene Knockout Animal Model
   Patent No.: ZL 2024 1 1077823.4
   Date of Grant: December 27, 2024
   Inventors: Xiang Yang, Wang Qiquan, Liu Yan, Tian Xiaoli, Lan Xinqiang, Wang Benhui, Huang Tiane