[1] 2008-09-2014-06 南开大学 博士（导师：龙加福 教授）

[2] 2004-09-2008-06 天津大学 本科

[1] 2024-01-今 研究员 南昌大学生物医学创新研究院/第二附属医院

[2] 2017-12-2024-01 副研究员（课题组长：张宏 院士） 中国科学院生物物理研究所

[3] 2014-08-2017-11 博士后（合作导师：张宏 院士） 中国科学院生物物理研究所

原创探索计划项目2024

面上项目2018

研究论文：

(1) Zheng Wang*#, Chun Yang*, Dongshi Guan, Jiaqi Li, and Hong Zhang. (2023) Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates. Developmental Cell, 58(11), 919-932. (Featured article and highlighted by Rohit V. Pappu in Developmental Cell entitled “Soaping up transcriptional condensates”). (唯一通讯作者，共同一作).

(2) Zheng Wang, Di Chen, Dongshi Guan, Xiaobo Liang, Jianfeng Xue, Hongyu Zhao, Guangtao Song, Jizhong Lou, Yan He, and Hong Zhang#. (2022) Material properties of phase-separated TFEB condensates regulate the autophagy-lysosome pathway. Journal of Cell Biology, 221(5): e202112024. (第一作者).

(3) Zheng Wang, Gangming Zhang, and Hong Zhang#. (2019) Protocol for analyzing protein liquid–liquid phase separation. Biophysics Reports, 5(1): 1-9. (第一作者).

(4) Zheng Wang*, Guangyan Miao*, Xue Xue*, Xiangyang Guo, Chongzhen Yuan, Zhaoyu Wang, Gangming Zhang, Yingyu Chen, Du Feng, Junjie Hu, and Hong Zhang#. (2016) The Vici syndrome protein EPG5 is a Rab7 effector that determines the fusion specificity of autophagosomes with late endosomes/lysosomes. Molecular Cell, 63(5): 781-795. (Recommended as a “very good” “new finding” in “Faculty of 1000”). (共同一作).

(5) Zheng Wang*, Xue Yang*, Shuang Guo, Yin Yang, Xun-Cheng Su, Yuequan Shen#, and Jiafu Long#. (2014) Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism. Journal of Biological Chemistry, 289(40): 27376-27385. (共同一作).

(6) Zheng Wang*, Xue Yang*, Xinlei Chu, Jinxiu Zhang, Hao Zhou, Yuequan Shen#, and Jiafu Long#. (2012) The structural basis for the oligomerization of the N-terminal domain of SATB1. Nucleic Acids Research, 40(9): 4193-4202. (共同一作).

(7) Jianfeng Xue, Zheng Wang, and Yan He#. (2022) Viscosity Measurement in Biocondensates Using Deep-Learning-Assisted Single-Particle Rotational Analysis. The Journal of Physical Chemistry, 126(39): 7541-7551.

(8) Di Chen, Zheng Wang, Yan G Zhao, Hui Zheng, Hongyu Zhao, Nan Liu, and Hong Zhang#. (2020) Inositol polyphosphate multikinase inhibits liquid-liquid phase separation of TFEB to negatively regulate autophagy activity. Developmental Cell, 55(5): 588-602.

(9) Wenyan Qu, Zheng Wang, and Hong Zhang#. (2020) Phase separation of the C. elegans Polycomb protein SOP-2 is modulated by RNA and sumoylation. Protein & Cell, 11(3): 202-207.

(10) Gangming Zhang, Zheng Wang, Zhuo Du, and Hong Zhang#. (2018) mTOR regulates phase separation of PGL granules to modulate their autophagic degradation. Cell, 174(6): 1492-1506.

(11) Yan G Zhao, Yong Chen, Guangyan Miao, Hongyu Zhao, Wenyan Qu, Dongfang Li, Zheng Wang, Nan Liu, Lin Li, She Chen, Pingsheng Liu, Du Feng, and Hong Zhang#. (2017) The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Molecular Cell, 67(6): 974-989.

(12) Fan Wu*, Yasunori Watanabe*, Xiangyang Guo*, Xin Qi*, Peng Wang, Hongyu Zhao, Zheng Wang, Yuko Fujioka, Hui Zhang, Jinqi Ren, Tiancheng Feng, Yuxian Shen, Wei Feng, Junjie Hu, Nobuo N Noda#, and Hong Zhang#. (2015) Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy. Molecular Cell, 60(6): 914-929.

(13) Huisha Xu*, Zhijie Lin*, Fengzhi Li*, Wentao Diao*, Chunming Dong, Hao Zhou, Xingqiao Xie, Zheng Wang, Yuequan Shen#, and Jiafu Long#. (2015) Dimerization of elongator protein 1 is essential for Elongator complex assembly. Proceedings of the National Academy of Sciences, 112(34): 10697-10702.

(14) Chunming Dong*, Zhijie Lin*, Wentao Diao, Dan Li, Xinlei Chu, Zheng Wang, Hao Zhou, Zhiping Xie, Yuequan Shen#, and Jiafu Long#. (2015) The Elp2 subunit is essential for elongator complex assembly and functional regulation. Structure, 23(6): 1078-1086.

(15) Lele Wang*, Xue Yang*, Siwei Li, Zheng Wang, Yu Liu, Jianrong Feng, Yushan Zhu, and Yuequan Shen#. (2014) Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. The EMBO Journal, 33(6): 594-604.

(16) Quanxiu Li, Chuangye Yan, Huisha Xu, Zheng Wang, Jiafu Long, Wenqi Li, Jianping Wu, Ping Yin#, and Nieng Yan#. (2014) Examination of the dimerization states of the single-stranded RNA recognition protein pentatricopeptide repeat 10 (PPR10). Journal of Biological Chemistry, 289(45): 31503-31512.

(17) Ping Yin, Quanxiu Li, Chuangye Yan, Ying Liu, Junjie Liu, Feng Yu, Zheng Wang, Jiafu Long, Jianhua He, Hong-Wei Wang, Jiawei Wang, Jian-Kang Zhu, Yigong Shi, and Nieng Yan#. (2013) Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature, 504(7478): 168-171.

(18) Boyang Cui*, Xue Yang*, Siwei Li*, Zhijie Lin, Zheng Wang, Cheng Dong, and Yuequan Shen#. (2013) The inhibitory helix controls the intramolecular conformational switching of the C-terminus of STIM1. PLoS One, 8(9): e74735.

(19) Xinlei Chu*, Xiaohong Qin*, Huisha Xu, Lei Li, Zheng Wang, Fengzhi Li, Xingqiao Xie, Hao Zhou, Yuequan Shen#, and Jiafu Long#. (2013) Structural insights into Paf1 complex assembly and histone binding. Nucleic Acids Research, 41(22): 10619-10629.

(20) Xingqiao Xie*, Xiaojie Yan*, Zheng Wang, Hao Zhou, Wentao Diao, Weihong Zhou, Jiafu Long#, and Yuequan Shen#. (2013) Open closed motion of Mint2 regulates APP metabolism. Journal of Molecular Cell Biology, 5(1): 48-56.

(21) Xingliang Zhang, Qi Zhang, Qi Xin, Lin Yu, Zheng Wang, Wei Wu, Lun Jiang, Guoqiang Wang, Wenli Tian, Zengqin Deng, Yang Wang, Zhao Liu, Jiafu Long, Zhizhong Gong, and Zhongzhou Chen#. (2012) Complex structures of the abscisic acid receptor PYL3/RCAR13 reveal a unique regulatory mechanism. Structure, 20(5): 780-790.

(22) Zhijie Lin, Weijing Zhao, Wentao Diao, Xingqiao Xie, Zheng Wang, Jinxiu Zhang, Yuequan Shen, and Jiafu Long. (2012) Crystal structure of elongator subcomplex Elp4-6. Journal of Biological Chemistry, 287(25): 21501-21508.

(23) Jinxiu Zhang*, Xue Yang*, Zheng Wang, Hao Zhou, Xingqiao Xie, Yuequan Shen#, and Jiafu Long#. (2012) Structure of an L27 domain heterotrimer from cell polarity complex Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly mode. Journal of Biological Chemistry, 287(14): 11132-11140.

(24) Huaimin Wang, Zheng Wang, Xiaoyi Yi, Jiafu Long, Jianfeng Liu, and Zhimou Yang#. (2011) Anti-degradation of a recombinant complex protein by incorporation in small molecular hydrogels. Chemical Communications, 47(3): 955-957.

(25) Xue Yang*, Xingqiao Xie*, Liu Chen, Hao Zhou, Zheng Wang, Weijing Zhao, Ran Tian, Rongguang Zhang, Changlin Tian, Jiafu Long#, and Yuequan Shen#. (2010) Structural basis for tandem L27 domain-mediated polymerization. The FASEB Journal, 24(12): 4806-4815.

综述论文：

(1) Zheng Wang#, Jizhong Lou#, and Hong Zhang#. (2022) Essence determines phenomenon: Assaying the material properties of biological condensates.

Journal of Biological Chemistry, 298(4):101782. (共同通讯作者).

(2) Zheng Wang, and Hong Zhang#. (2019) Phase separation, transition, and autophagic degradation of proteins in development and pathogenesis. Trends in Cell Biology, 29(5): 417-427. (Cover story). (第一作者).

(3) Nobuo N Noda#, Zheng Wang, and Hong Zhang#. (2020) Liquid-liquid phase separation in autophagy. Journal of Cell Biology, 219(8): e202004062.

(4) Hong Zhang#, Xiong Ji#, Pilong Li#, Cong Liu#, Jizhong Lou#, Zheng Wang, Wenyu Wen#, Yue Xiao, Mingjie Zhang#, and Xueliang Zhu#. (2020) Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases. Science China Life Sciences, 63(7): 953-985.

专利：

(1) 张宏, 王峥。一种基于生物大分子液态凝聚体物理性质的小分子化合物筛选方法。2021-6-29，中国，申请号：202110727224.2。

(2) 张宏，王峥。喹啉噻唑啉酮衍生物Ro-3306在神经退行性疾病治疗中的应用。2021-6-29，中国，专利号：202110727932.6。

(3) 张宏，王峥，邓红雨，孙龙，蔡启良，都树娟。喹啉噻唑啉酮衍生物Ro-3306在治疗β-冠状病毒感染中的应用。2021-6-29，中国，专利号：202110727833.8。