个人信息姓名：余华
国籍：中国
性别：男
毕业院校：中国科学院大学遗传与发育生物学研究所
职称：教授
学位：博士
电子邮件：huayu@ncu.edu.cn
所在单位：生物医学创新研究院
办公地址：南昌大学前湖校区南院科创大楼219室
个人信息研究兴趣与领域：致力于非编码RNA功能研究，发现驱动多能干细胞全能性命运转变、合子基因组激活以及癌症发生发展的关键非编码RNA，解析其调控的分子机制。
教研室：生物化学与分子生物学。
[1] 201309-201707 中国科学院遗传与发育生物学研究所 博士研究生
[2] 201009-201307 西北农林科技大学 硕士研究生
[3] 200609-201007 安徽科技学院 大学本科
[1] 202212-202302 西湖实验室 西湖实验室
[2] 202109-202212 西湖大学 西湖大学
[3] 201804-202106 浙江大学 浙江大学
[4] 201708-201803 南通大学 南通大学
小鼠胚胎干细胞多能性与全能性命运转变关键eRNA分子系统性鉴定及其调控网络解析
哺乳动物早期胚胎细胞全能性建立关键保守性非编码RNA分子识别与验证
小鼠合子基因组激活关键eRNA分子鉴定
代表性论文 (#共同第一作者，*通讯作者)
1.Hua Yu#*, Jing Zhao#, Yuxuan Shen, Qiao Lu, Yuheng Liu, Guanglei Xie, Shuhui Chang, Tingying Ge, Nan Li, Ming Chen, Hu Li, Jin Zhang*, Xi Wang*. The dynamic landscape of enhancer-derived RNA during mammalian early embryo development.Cell Reports, 2024, 43(4):114077.
2.Hua Yu#, Zhen Sun#, Tianyu Tan#, Hongru Pan#, Jing Zhao, Ling Zhang, Jiayu Chen, Yuqing Zhu, Lang Chen, Yuyan Xu, Shaorong Gao, George Q. Daley, Jin Zhang*. rRNA Biogenesis Regulates Mouse 2C-like State by 3D Structure Reorganization of Peri-Nucleolar Heterochromatin. Nature Communications, 2021, 12:6365.
3.Anhua Lei#, Hua Yu#, Shan Lu, Hengxing Lu, Xizhong Ding, Tianyu Tan, Hailing Zhang, Mengmeng Zhu, Lin Tian, Xudong Wang, Siyu Su, Dixuan Xue, Shaolong Zhang, Wei Zhao, Yuge Chen, Wanrun Xie, Li Zhang, Yuqing Zhu, Jing Zhao, Wenhong Jiang, George Church, Francis Ka-Ming Chan, Zhihua Gao, Jin Zhang*. A second generation M1-polarized CAR macrophage with antitumor efficacy. Nature Immunology, 2023, 25:102-116.
4.Zhen Sun#, Hua Yu#, Jing Zhao#, Tianyu Tan, Hongru Pan, Bo Gao, Yuqing Zhu, Lang Chen, Cheng Zhang, Li Zhang, Anhua Lei, Yuyan Xu, Xianju Bi, Xin Huang, Cristina Correia, Ming Chen, Qiming Sun, Li Shen, Longfei Wang, Yu Feng, Jianlong Wang, Xiaohua Shen, Hu Li, Hao Wu, George Q. Daley, Jin Zhang*. LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells. Protein & Cell, 2021, 13:490-512.
5.Jing Zhao#, Ke Yao#, Hua Yu#, Ling Zhang, Yuyan Xu, Lang Chen1, Zhen Sun, Yuqing Zhu, Chen Zhang, Yuli Qian, Zhuyan Ji, Min Zhang, Jie Chen, Cristina Correia, Taylor Weiskittel, Dan Zhang, Hu Li, Wei Xie, Zeping Hu*, Jin Zhang* Metabolic remodelling during early mouse embryo development. Nature Metabolism, 2021, 3:1372-1384
6. Lin Yang, Yuqing Zhu#, Hua Yu#, Xiaolong Cheng, Sitong Chen, Yulan Chu, He Huang, Jin Zhang*, Wei Li*. scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens. Genome Biology, 2020, 21:19.
7. Hua Yu#*, Lu Lu#, Bingke Jiao, Chengzhi Liang*. Systematic discovery of novel and valuable plant gene modules by large-scale RNA-seq samples. Bioinformatics, 2019, 35(3):361-364.
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