[1] 201409-201906 南昌大学 博士研究生

[2] 201009-201406 南昌大学科学技术学院 大学本科

[1] 202208-至今 讲师 南昌大学

[2] 201907-202206 博士后 南昌大学

国家自然科学基金地区项目

赣鄱俊才支持计划-主要学科学术和技术带头人培养项目

中国博士后科学基金面上项目

重庆市自然科学基金面上项目

江西省自然科学基金青年基金项目

江西省博士后科研择优资助

江西省博士后日常资助

横向课题

以第一或通讯作者发表的论文情况：

[1] Yu T, Li M, Zhang H, Hu J, Li M, Zhang Q, Liu X, Fu Z, Hu C*, Xu X*. Zebrafish ZDHHC11 palmitoylates STING to potentiate antiviral immune response. Cell Communication and Signaling, 2026. 共同通讯作者

[2] Zhao K, Zhang Y, Yin Z, Tan L, Juario M, Zhang H, Liu Y, Xu P, Zhang Q, Zhao G, Wang S, Mao H, Xu X*, Hu C*. GCRV-II major outer capsid protein VP4 promotes cell apoptosis by VDAC2-mediated calcium pathway facilitation. International Journal of Biological Macromolecules, 2025, 285, 138273. 共同通讯作者

[3] Guo R, Wu Y, Yu T, Guo C, Yin Z, Zhao G, Li M, Mao H, Hu C, Xu X*. Tetrachlorantraniliprole induces neurodevelopmental toxicity through oxidative stress-mediated apoptosis and dysregulation of Wnt signaling pathway. Aquatic Toxicology, 2025, 279, 107229. 通讯作者

[4] Zhang Y, Zhao K, Liu Y, Xu J, Zhang H, Yin Z, Xu P, Jiang Z, Wang S, Mao H, Xu X*, Hu C*. An oral probiotic vaccine loaded by Lactobacillus casei effectively increases defense against GCRV infection in grass carp. Vaccine, 2025, 45, 126660. 共同通讯作者

[5] Yu T, Li M, Li M, Wang S, Feng Z, Zhang H, Liu J, Mao H, Li D, Hu C*, Xu X*. Zebrafish (Danio rerio) TDP43 negatively regulates PKZ-IRF3–mediated IFN I response. Journal of Immunology, 2025, 214(4): 726-746.共同通讯作者

[6] Yu T, Li M, Li M, Zhang Q, Zhang H, Jiang Z, Wang S, Mao H, Li D, Fan L, Hu C*, Xu X*. Zebrafish TDP43 positively regulates p65-mediated apoptotic pathway. International Journal of Biological Macromolecules, 2025, 27, 142599. 共同通讯作者

[7] Zhang Q, Yu T, Wang Z, Li M, Xu J, Liu X, Qian C, Yin Z, He G, Hu M, Zhang B, Liu J, Fu Z, Wang S*, Xu X*, Hu C. RBCK1 enhances antiviral response through promoting K63-linked polyubiquitination of IRF7 in Carassius auratus var. Pengze. Fish and Shellfish Immunology, 2025, 165, 110532.共同通讯作者

[8] Zhang H, Liu X, Yin Z, Zhao K, Zhang Q, Yu T, Liu J, Zhang B, Hu M, Jiang Z, Li M, Wang S, Hu C*, Xu X*. ISGylation of zebrafish STING at lysines 221 and 276 activates innate immunity. Fish and Shellfish Immunology, 2025, 166, 110640. 共同通讯作者

[9] Guo C, Yu T, Guo R, Li M, Huang X, Wu Y, Tang J, Zhang Z, Wang S, Hu C*, Xu X*. Gpx4a-mediated ferroptosis underlines prothioconazole-induced ocular defects in early-life zebrafish. Water Biology and Security, 2025. 共同通讯作者

[10] Yin Z, Zhang H, Zhao K, Liu Y, Guo R, Xu P, Zhao G, Hu M, Hu C, Xu X*. Zebrafish FKBP5 facilitates apoptosis and SVCV propagation by suppressing NF-κB signaling pathway. Fish and Shellfish Immunology, 2024, 155, 110021. 通讯作者

[11] Li MM, Tao CB, Li MF, Wu CX, Yu TT, Feng ZQ, Zhang Q, Jiang ZY, Mao HL, Wang SH, Xu XW*, Hu CY*. A molecular mechanism underlies grass carp (Ctenopharyngodon idella) TARBP2 regulating PKR-mediated cell apoptosis. Fish and Shellfish Immunology, 2024, 154, 109906. 共同通讯作者

[12] Li M, Hu J, Zhou J, Wu C, Li D, Mao H, Kong L, Hu C*, Xu X*. Grass carp (Ctenopharyngodon idella) deacetylase SIRT1 targets p53 to suppress apoptosis in a KAT8 dependent or independent manner. Fish and Shellfish Immunology, 2023, 109264. 共同通讯作者

[13] Han X#, Xu X#, Yu T, Li M, Liu Y, Lai J, Mao H, Hu C, Wang S*. Dilfubenzuron Induces Cardiotoxicity in Zebraflsh Embryos. International Journal of Molecular Sciences, 2022, 23, 11932. 共同第一作者

[14] Xiong Y, Wang C*, Dong M, Li M, Hu C, Xu X*. Chlorphoxim induces neurotoxicity in zebrafish embryo through activation of oxidative stress. Environmental Toxicology, 2022, 10: 1-13. 共同通讯作者

[15] Yu T, Zeng Q, Mao H*, Liu Y, Zhang H, Wang S, Hu C, Xu X*. Grass carp (Ctenopharyngodon idella) NLK2 inhibits IFN I response through blocking MAVS-IRF3 axis. Fish and Shellfish Immunology, 2022, 131: 206-217. 共同通讯作者

[16] Wang S, Han X, Yu T, Liu Y, Zhang H, Mao H, Hu C, Xu X*. Isoprocarb causes neurotoxicity of zebrafish embryos through oxidative stress-induced apoptosis. Ecotoxicology and Environmental Safety, 2022, 242, 113870. 通讯作者

[17] Li M, Hu J, Mao H, Li D, Jiang Z, Sun Z, Yu T, Hu C*, Xu X*. Grass Carp (Ctenopharyngodon idella) KAT8 inhibits IFN 1 response through acetylating IRF3/IRF7. Frontiers in Immunology, 2022, 12, 808159. 共同通讯作者

[18] Xu X, Li M, Deng Z, Li D, Lu S, Deng H, Lv Y, Liu Y, Du H, Hu C*. Grass carp Mre11A activates IFN 1 response by targeting STING to defend against GCRV infection. Developmental and Comparative Immunology, 2021,116, 103909. 第一作者

[19] Xu X, Li M, Deng Z, Hu J, Jiang Z, Liu Y, Chang K, Hu C*. Grass Carp (Ctenopharyngodon idellus) NIMA-Related Kinase Blocks dsRNA-Induced IFN Response by Targeting IRF3. Frontiers in Immunology. 2021, 11, 597775. 第一作者

[20] Li M, Yu T, Lai J, Han X, Hu J, Deng Z, Li D, Ye Z, Wang S, Hu C*, Xu X*. Ethoprophos induces cardiac toxicity in zebrafish embryos. Ecotoxicology and Environmental Safety. 2021, 228, 113029. 共同通讯作者

[21] Xu X, Li M, Deng Z, Jiang Z, Li D, Wang S, Hu C*. cGASa and cGASb from grass carp (Ctenopharyngodon idellus) play opposite roles in mediating type I interferon response. Developmental and Comparative Immunology, 2021, 125, 104233. 第一作者

[22] Lu S, Peng X, Lin G, Xu K, Wang S, Qiu W, Du H, Chang K, Lv Y, Liu Y, Deng H, Hu C, Xu X*. Grass carp (Ctenopharyngodon idellus) SHP2 suppresses IFN I expression via decreasing the phosphorylation of GSK3β in a non-contact manner. Fish and Shellfish Immunology. 2021, 116: 150-160. 通讯作者

[23] Xu X, Li M, Wu C, Li D, Jiang Z, Liu C, Cheng B, Mao H, Hu C. The Fish-Specific Protein Kinase (PKZ) Initiates Innate Immune Responses via IRF3- and ISGF3-Like Mediated Pathways. Frontiers in Immunology. 2019, 10, 582. 第一作者

[24] Xu X, Li M, Li D, Jiang Z, Liu C, Shi X, Wu C, Chen X, Lin G, Hu C* Identification of the SAMHD1 gene in grass carp and its roles in inducing appotosis and inhibiting GCRV proliferation. Fish & Shellfish Immunology, 2019, 88: 606-618. 第一作者

[25] Xu X, Li M, Wu Z, Wang H, Wang L, Huang K, Liu X, Hou Q, Lin G, Hu C* Endoplasmic reticulum transmembrane proteins ZDHHC1 and STING both act as direct adaptors for IRF3 activation in teleost. Journal of Immunology, 2017, 199(10):3623-3633. 第一作者

[26] Xu X, Lai Q, Gu M, Liu D, Hou Q, Liu X, Mi Y, Sun Z, Wang H, Lin G, Hu C* Fish IRF3 up-regulates the transcriptional level of IRF1, IRF2, IRF3 and IRF7 in CIK cells. Fish & Shellfish Immunology, 2015,47:978-985. 第一作者

[27] 胡美玲，于婷婷，卢君焱，花佳丽，龚慧莹，杨珊珊，胡成钰，徐小文*. 斑马鱼TDP43负调控Ⅰ型干扰素的表达. 南昌大学学报（理科版），2024，48(2): 173-182. 通讯作者

[28] 胡成钰，张岩松，徐小文*. 鱼用疫苗研究进展. 南昌大学学报（理科版），2024，48(1): 77-86. 通讯作者

[29] 胡霁欢，胡美玲，史晓，周鹏程，常凯乐，向阳，徐小文*. 草鱼（Ctenopharyngodon idella）长链非编码RNA ISG152-L2激活IRF3和ISG152的表达，南昌大学学报（理科版），2023，47(3):272-282. 通讯作者

专利情况：

[1] 徐小文，袁鸿杰，黎美凤，毛慧玲，胡成钰，王尚洪. 一种适用于鱼类的免疫增强剂及应用. 发明专利，202410497873.1

[2] 徐小文，叶作城，黎美凤，毛慧玲，胡成钰. 一种鱼用DNA疫苗及其制备方法及应用. 发明专利，202210007548.3，授权，已转化

[3] 胡成钰，赵凯文，徐小文，王尚洪. 一种鱼类应激反应测试装置. 发明专利，202310819117.1

[4] 黎美凤，刘宝，刘静，李俊杰，赵智卓，张旭程，王毅豪，徐小文. 一种草鱼养殖用喂食装置. 实用新型专利，202421052611.6，授权

[5] 赵凯文，徐小文，胡成钰，毛慧玲，王尚洪. 一种鱼用二价口服疫苗、制备方法及应用. 发明专利，202511795405.3

[6] 赵凯文，胡成钰，徐小文. 一种用于聊天机器人的多任务智能问答方法及系统. 发明专利，202310298317.7，授权

[7] 汪丹雯，徐小文，田飞焱，王尚洪，胡成钰. 一种基于RPA-CRISPR-Cas12a系统的鲤科Ⅱ型疱疹病毒可视化检测试剂及应用. 发明专利，202511231167.3