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Research Direction: Tumor and cellular senescence — investigating the molecular mechanisms and potential molecular targets of tumorigenesis from the perspective of cellular senescence
Affiliation: Institute of Human Aging
Lab Website: www.zhaoliminlab.cn
Education
2009.09 – 2013.06 | Henan Normal University, College of Life Sciences, Biotechnology — Bachelor's degree
2013.09 – 2019.06 | University of Chinese Academy of Sciences, Kunming Institute of Zoology, Cell Biology — Ph.D.
Work Experience
2019.07 – 2020.04 | Kunming Institute of Zoology, Chinese Academy of Sciences — Assistant Research Fellow
2020.04 – 2020.12 | Kunming Institute of Zoology, Chinese Academy of Sciences — Associate Research Fellow
2020.12 – Present | Nanchang University — Professor
Teaching Courses
Undergraduate courses: Immunology, Cell Biology
Funded Research Projects
Jiangxi Province "Double Thousand Plan" Innovative Leading Talent (Youth Category), 2022–2025, ¥1,000,000, jxsq2023101075
Jiangxi Provincial Outstanding Youth Science Foundation, 2023.07–2027.06
National Natural Science Foundation of China, 2023.01–2025.12
National Natural Science Foundation of China, 2023.01–2026.12
Chongqing Municipal Natural Science Foundation General Project, 2022.08–2024.07
CAS Special Research Assistant Funding Program (the sole recipient from Kunming Institute of Zoology, CAS in 2021), 2020.01–2021.12, ¥800,000
Jiangxi Provincial Natural Science Foundation General Project, 2023.01–2025.12
Yunnan Provincial General Project, 2020–2023, Principal Investigator
Representative Publications
(# co-first author; * co-corresponding author)
Liang Lin#, Hao Ke#*, Mengxin Chen#, Yi Zhang#, Shiting Fu, Fan Yu, Jianbin Su, Xing Yang, Yingqi Guo, Qianzhe Ding, Yuhan Zhang, Limin Zhao*. "Downregulation of TDP43 by atovaquone inhibits oxidative phosphorylation and enhances sensitivity of triple-negative breast cancer to EGFR-TKIs." Free Radical Biology and Medicine, Volume 250, July 2026. Last corresponding author.
Mengxin Chen#, Taiping Xiao#, Hao Ke#, Chun Ye, Fan Yu, Jianbin Su, Shixin Yang, Yun Feng, Huaimeng Xu, Shiting Fu, Liang Lin, Junqiang Lin, Yao Xie, Qianzhe Ding, Ye Qiu, Ruifan Yu, Hongyu Lv, Wulian Li, Yuhan Zhang, Zhenluo Ding, Yang Zou*, Huozhong Yuan*, Limin Zhao*. "Age-Related Aberrant Splicing and Its Role in Elderly Breast Cancer Prognosis." Communications Biology, 2025.12. Last corresponding author.
Junqiang Lin#, Ye Qiu#, Chun Ye, Yuhan Zhang, Zile Zeng, Bingtao Yao, Yidan Hu, Limin Zhao*. "RNA and protein degradation in the aging process." 2025 Dec;136:112166. Cellular Signalling. Last corresponding author.
Xia Wu#, Mengxin Chen#, Kang Liu#, Yixin Wu, Yun Feng, Shiting Fu, Huaimeng Xu, Yongqi Zhao, Feilong Lin, Liang Lin, Shihui Ye, Junqiang Lin, Taiping Xiao, Wenhao Li, Meng Lou, Hongyu Lv, Ye Qiu, Ruifan Yu, Wenyan Chen, Mengyuan Li, Xu Feng, Zhongbing Luo, Lu Guo, Hao Ke*, and Limin Zhao*. "Molecular classification of geriatric breast cancer displays distinct senescent subgroups of prognostic significance." 2024 Aug 15;35(4):102309. Molecular Therapy: Nucleic Acids. Last corresponding author.
Shiting Fu#, Hao Ke#, Huozhong Yuan#, Huaimeng Xu, Wenyan Chen, Limin Zhao*. "Dual role of pregnancy in breast cancer risk." 2024 Jun 1:352:114501. General and Comparative Endocrinology. Last corresponding author.
Hao Ke#, Kang Liu, Baowei Jiao*, Limin Zhao*. "Implications of TDP-43 in non-neuronal systems." 2023 Nov 23;21(1):338. Cell Communication and Signaling. Last corresponding author.
Junqiang Lin#, Hao Ke#, Shihui Ye#, Mengfei Guo, Baowei Jiao*, Ceshi Chen*, Limin Zhao*. "Changes in the mammary gland during aging and its relationship with breast diseases." 2023 May 15;55(6):1001–1019. Acta Biochimica et Biophysica Sinica. Last corresponding author.
Guo L#, Ke H#, Zhang H, Zou L, Yang Q, Lu X, Zhao L*, and Jiao B*. "TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms." 2022 May 3;13(5):428. Cell Death & Disease. Corresponding author.
Zhao L*, Ke H*, Xu H, Wang G, et al. "TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh." Nature Communications. 2020; 11(1): E341. First author.
Ke H*, Zhao L*, Zhang H*, Feng X, et al. "Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3." PNAS. 2018; 115(15): E3426–E3435. Co-first author.
Zhao L*, Li L*, Xu H, Ke H, et al. "TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells." Stem Cells and Development. 2019;28(14):944–953. First author.
Ke H*, Zhao L*, Feng X, Xu H, et al. "NEAT1 is required for survival of breast cancer cells through FUS and miR-548." Gene Regulation and Systems Biology. 2016;10(Suppl 1):11–17. Co-first author.
Patents & Awards
Patents:
An optimization method for large-scale virtual drug screening. Inventors: Hao Ke, Yanfei Peng, Limin Zhao, Xia Wu. Patent No. CN 115862768 B. Granted: September 1, 2023.
A method for constructing a senescence scoring model for elderly breast cancer and its application. Inventors: Limin Zhao, Xia Wu, Hao Ke, Mengxin Chen, Yixin Wu, Kang Liu, Liang Lin, Yun Feng, Junqiang Lin, Feilong Lin, Yongqi Zhao. Patent Application No. CN 117746983 B. Granted: September 3, 2024.
Application of TDP-43 gene in predicting maternal milk production. Patent No. 201911086725.6. Granted.
Awards:
Yunnan Provincial Natural Science Award (Third Class): Molecular mechanisms of breast cancer heterogeneity. Baowei Jiao, Hao Ke, Limin Zhao, 2022.
Jiangxi Provincial Medical Science and Technology Award (Second Class): Function and mechanism of TDP-43 in breast diseases. Hao Ke, Limin Zhao, Shixin Yang, 2025.