学科方向：新资源食品、食品酶学、食品质量与安全

所属院系：食品学院

研究方向

1、食品营养与健康：食物活性组分的稳态化及其对慢性病的营养调控；

2、食品递送与高效利用：食品运载体系的构建及其对营养物质的靶向递送与控释；

3、食品质量与安全：食品中化学有害物的危害形成机制及其检测新技术；

4、食品化学与分析：食品生物大分子与天然活性成分相互作用、功能性质及应用研究；

5、食品生物技术：功能性糖、稀有糖的酶法转化制备食品酶高产菌株的筛选构建；

6、食品加工新技术原理及应用等方向的研究工作。

个人经历

胡兴，女，南昌大学食品学院副教授，食品科学专业工学博士，硕士研究生导师，现任江西省科技特派团黎川果业团团长。
目前主持国家自然科学基金2项、江西自然科学基金面上项目和重点项目各1项、横向课题2项，参与国家十二五863计划、国家自然科学基金、江西省重大科技项目等国家级和省部级科研项目10余项。主讲《食品分析》、《食品分析实验》、《现代食品检测技术》、《现代食品检测技术实验》等课程。担任Journal of Agricultural and Food Chemistry、Food Bioscience、Journal of Functional Foods、Food and Chemical Toxicology等学术期刊审稿专家，在Comprehensive Reviews in Food Science and Food Safety、Journal of Agricultural and Food Chemistry、《食品科学》等国内外权威学术期刊上发表论文80余篇，其中SCI收录70余篇，论文总被引3145次，H-index 28；撰写英文专著1部、中文专著2部。
个人荣誉：江西省教学成果一等奖2次（2021年度、2023年度）、南昌大学授课质量优秀奖7次、全省防疫期间线上教学优质课一等奖（2021年度）、“优秀本科生班级导师”（2019年度、2023年度）。
邮箱：hx0726@ncu.edu.cn

讲授课程

《食品分析》、《现代食品检测技术》、《食品分析实验》 、《现代食品检测技术实验》

学术成就

发表论文：

(1) Jianmei Wu, Xinyue Hong, Xing Hu*, Deming Gong, Guowen Zhang*. Glycosylation and binding of α-dicarbonyl compounds and human serum albumin based on spectral analysis and molecular simulation. Journal of Molecular Structure. 2024. (Accepted)
(2) Shuang Xiao, Peng Zhang, Guowen Zhang, Wenwen Li, Haowen Lin, Xing Hu*. Inhibition of toll-like receptor 4 activation by apigenin and chrysin via competition for sites and conformational changes. International Journal of Biological Macromolecules, 2023, 252: 126415.
(3) Wenli Shi, Guowen Zhang, Yijing Liao, Xiaoyun Fei, Deming Gong, Xing Hu*. Anti-acetylcholinesterase mechanism of kaempferol and its synergistic effect with galanthamine hydrobromide. Food Bioscience, 2023, 56: 103174.
(4) Xiao shuang, Xiaoqiao Luo, Peng Zhang, Shuang Xiao, Deming Gong, Guowen Zhang, Xing Hu*. Purification and Characterisation of a Novel Recombinant D-Mannose Isomerase from Bifidobacterium[J]. Enzyme and Microbial Technology, 2024, 173: 110355.
(5) Haihua Jiang, Xiaoyun Fei, Guowen Zhang*, Xing Hu, Deming Gong, Junhui Pan*. Complexing with fibrillated glutenin and orange peel pectin improves the aqueous dispersion and storage stability of hesperitin/hesperidin. Food Hydrocolloids, Volume 145, December 2023, 109138.
(6) Xi Peng, Kai Liu, Xing Hu, Deming Gong, Guowen Zhang*. Hesperetin-Cu(II) complex as potential α-amylase and α-glucosidase inhibitor: Inhibition mechanism and molecular docking. Spectrochim Acta A Mol Biomol Spectrosc, 2023 Apr 5;290:122301. doi: 10.1016/j.saa.2022.122301.
(7) Jianmei Wu, Xinyue Hong, Xing Hu, Deming Gong, Guowen Zhang*. Glycosylation of Human Serum Albumin Induced by Α-Dicarbonyl Compounds. 2023, SSRN Electronic Journal.
(8) Guowen Zhang, Miao Zhu, Yijing Liao, Deming Gong, Xing Hu*. Action mechanisms of two key xanthine oxidase inhibitors in tea polyphenols and their combined effect with allopurinol. Journal of the Science of Food and Agriculture, 2022, 102(15): 7195–7208.
(9) Yijing Liao, Xing Hu, Junhui Pan, Guowen Zhang*. Inhibitory mechanism of baicalein on acetylcholinesterase: Inhibitory Interaction, Conformational Change, and Computational Simulation. Foods 11(2): 168. DOI:10.3390/foods11020168

(10) Hu Xing #, Luo Xiaoqiao, Zhou Zhisheng, Wang Rui, Hu Yaqin, Zhang Guimei and Guowen Zhang*. (2021). Multi-Spectroscopic and Molecular Simulation Approaches to Characterize the Intercalation Binding of 1-Naphthaleneacetic Acid With Calf Thymus DNA. Front. Toxicol., https://doi.org/10.3389/ ftox.2021.620501

(11) Zhu Miao#, Hu Xing *, Zhang Ying, Pan Junhui, Zhang Guowen*. (2021). Revealing the groove binding characteristics of plant growth regulator 3-indoleacetic acid with calf thymus DNA. Journal of Molecular Liquids, 326:115265.

(12) Li Sha#, Hu Xing*, Pan Junhui, Gong Deming, Zhang Guowen*. (2021). Mechanistic insights into the inhibition of pancreatic lipase by apigenin: Inhibitory interaction, conformational change and molecular docking studies, Journal of Molecular Liquids, 335:116505.

(13) Zhang Guowen# , Zhou Zhisheng, Xu Jianjian, Liao Yijing, Hu Xing*. (2020). Groove binding between ferulic acid and calf thymus DNA: Spectroscopic methodology combined with chemometrics and molecular docking studies. Journal of Biomolecular Structure and Dynamics, 38(7): 2029-2037.

(14) Li Sha#, Pan Junhui, Hu Xing*, Zhang Ying, Gong Deming, Zhang Guowen*. (2020). Kaempferol inhibits the activity of pancreatic lipase and its synergistic effect with orlistat. Journal of Functional Foods, 72: 104041.

(15) Hu Xing, Du Jiawei, Wang Fengfeng, Pan Junhui, Gong Deming, Zhang Guowen*. (2019). Colorimetric detection of the β-agonist ractopamine in animal feed, tissue and urine samples using gold–silver alloy nanoparticles modified with sulfanilic acid. Food Additives & Contaminants: Part A, 36(1), 35–45.

(16) Zhang Peng, Chen Qian, Fu Guiming, Xia linglin, Hu Xing*. (2019). Regulation and metabolic engineering strategies for permeases of Saccharomyces cerevisiae. World Journal of Microbiology and Biotechnology, 35, 112.

(17) Zhang Guowen, Zhou Zhisheng, Xu Jianjian, Liao Yijing, Hu Xing*. (2019). Groove binding between ferulic acid and calf thymus DNA: Spectroscopic methodology combined with chemometrics and molecular docking studies. Journal of Biomolecular Structure and Dynamics, https://doi.org/10.1080/07391102.2019.1624194

(18) Zhang Peng, Li Bang, Wen Peng, Wang Peilin, Yang Yu, Chen Qian, Chang Yuxin, Hu Xing*. (2018). Metabolic engineering of four GATA factors to reduce the urea and ethyl carbamate formation in a model rice wine system. Journal of Agricultural and Food Chemistry, 66(41), 10881–10889.

(19) Zhang Peng, Hu Xing*. (2018). Metabolic engineering of arginine permeases to reduce the formation of urea in Saccharomyces cerevisiae. World Journal of Microbiology and Biotechnology, 34 (3), 47.

(20) Wu Xiaqing, Ding Huafang, Hu Xing*, Pan Junhui, Liao Yijing, Gong Deming, Zhang Guowen*. (2018). Exploring inhibitory mechanism of gallocatechin gallate on a-amylase and aglucosidase relevant to postprandial hyperglycemia. Journal of Functional Foods, 48, 200–209.

(21) Hu Xing, Shi Yaning, Zhang Peng, Miao Ming, Zhang Tao, Jiang Bo*. (2016). D-Mannose: Properties, production and applications—an overview. Comprehensive Reviews in Food Science and Food Safety, 15(4), 773–785.

(22) Hu Xing, Zhang Peng, Miao Ming, Zhang Tao, Jiang Bo*. (2016). Development of a recombinant D-mannose isomerase and its characterizations for D-mannose synthesis. International Journal of Biological Macromolecules, 89, 328–335.

(23) Zhang Guowen*, Hu Xing, Fu Peng, (2012). Spectroscopic studies on the interaction between carbaryl and calf thymus DNA with the use of ethidium bromide as a fluorescence probe. Journal of Photochemistry and Photobiology B-biology, 108(1), 53–61.

(24) Zhang Guowen*, Hu Xing, Pan Junhui. (2011). Spectroscopic studies of the interaction between pirimicarb and calf thymus DNA. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 78(2), 687–694.

(25) Zhang Guowen*, Hu Xing, Zhao Nan. (2010). Studies on the interaction of aminocarb with calf thymus DNA by spectroscopic methods. Pesticide Biochemistry and Physiology, 98(2), 206–212.

(26) Du Jiawei, Hu Xing, Zhang Guowen *, Wu Xiaqing, Gong Deming. (2018). Colorimetric detection of cadmium in water using L–cysteine functionalized gold–silver nanoparticles. Analytical letter, 51(18), 2906–2919.

(27) Wang Rui, Hu Xing, Pan Junhui, Zhang Guowen*, Gong Deming. (2019). Interaction of isoeugenol with calf thymus DNA and its protective effect on DNA oxidative damage. Journal of Molecular Liquids, 282, 356–365.

(28) Wang Rui, Hu Xing, Pan Junhui, Gong Deming, Zhang Guowen*. (2018). Interaction between quinoline yellow and human serum albumin: Spectroscopic, chemometrics and molecular docking studies. Journal of the Science of Food and Agriculture, 99(1), 73–82.

(29) Ding Huafang, Hu Xing, Xu Ximing, Zhang Guowen*, Gong Deming. (2018). Inhibitory mechanism of two allosteric inhibitors, oleanolic acid and ursolic acid on α-glucosidase. International journal of biological macromolecules, 107, 1844–1855.

(30) Zhou Zhisheng, Hu Xing, Hong Xinyue, Zheng Jie, Liu Xia, Gong Deming, Zhang Guowen*. (2019). Interaction characterization of 5-hydroxymethyl-2-furaldehyde with human serum albumin: Binding characteristics, conformational change and mechanism. Journal of Molecular Liquids, https://doi.org/10.1002/jsfa.9536

(31) Zhou Zhisheng, Hu Xing, Zhang Guowen *, Wang Rui, Gong Deming. (2019). Exploring the binding interaction of Maillard reaction by‐product 5‐hydroxymethyl‐2‐furaldehyde with calf thymus DNA. Journal of the Science of Food and Agriculture, 99(6): 3192–3202.

(32) Zhang Guowen, Zhao Nan, Hu Xing, Tian Jiao. (2010). Interaction of alpinetin with bovine serum albumin: Probing of the mechanism and binding site by spectroscopic methods. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 76(3–4), 410–417.

(33) Qi Yang, Miao Ming *, Hu Xing, Jiang Bo, Jin Zhengyu, Zhang Tao. (2016). Impact of glucansucrase treatment on structure and properties of maize starch. Starch-Stärke, 69(7–8), 1600222.

(34) Fan Meihui, Zhang Guowen*, Hu Xing, Xu Ximing, Gong Deming. (2017). Quercetin as a tyrosinase inhibitor: Inhibitory activity, conformational change and mechanism. Food Research International, 100, 226–233.

(35) Zeng Li, Huafang Ding, Hu Xing, Guowen Zhang*, Deming Gong. (2019). Galangin inhibits α-glucosidase activity and formation of non-enzymatic glycation products. Food Chemistry, 271, 70–79.

(36) Ding Huafang, Wu Xiaqing, Pan Junhui, Hu Xing, Gong Deming, Zhang Guowen*, (2018). New insights into the inhibition mechanism of betulinic acid on alpha-glucosidase. Journal of Agricultural and Food Chemistry, 66(27), 7065–7075.

(37) Zeng Ni, Zhang Guowen*, Hu Xing, Pan Junhui, Zhou Zhisheng, Gong Deming. (2018). Inhibition mechanism of baicalein and baicalin on xanthine oxidase and their synergistic effect with allopurinol. Journal of Functional Foods, 50, 172–182.

(38) Zeng Ni, Zhang Guowen*, Hu Xing, Pan Junhui, Gong Deming. (2019). Mechanism of fisetin suppressing superoxide anion and xanthine oxidase activity. Journal of Functional Foods, 58, 1–10.

(39) Ni Mengting, Pan Junhui, Hu Xing, Gong Deming, Zhang Guowen*. (2019). Inhibitory effect of corosolic acid on α‐glucosidase: kinetics, interaction mechanism, and molecular simulation. Journal of the Science of Food and Agriculture, 99(13), 5881–5889.

(40) Wang Rui, Liu Yingying, Hu Xing, Pan Junhui, Gong Deming, Zhang Guowen*. (2019). New insights into the binding mechanism between osthole and β-lactoglobulin: Spectroscopic, chemometrics and docking studies. Food Research International, 120, 226–234.

(41) Wu Xiaqing, Hu Mingming, Hu Xing, Ding Huafang, Gong Deming, Zhang Guowen*. (2019). Inhibitory mechanism of epicatechin gallate on α-amylase and α-glucosidase and its combinational effect with acarbose or epigallocatechin gallate. Journal of Molecular Liquids, 290, 111202.

(42) Wu Xiaqing, Zhang Guowen*, Hu Xing, Pan Junhui, Liao Yijing, Ding Huafang. (2019). Inhibitory effect of epicatechin gallate on protein glycation. Food Research International, 122, 230–240.

(43) Ding Xinyue, Zeng Ni, Zhang Guowen*, Pan Junhui, Hu Xing, Gong Deming. (2019). Influence of transglutaminase-assisted ultrasound treatment on the structure and functional properties of soy protein isolate. Journal of Food Processing and Preservation, https://doi.org/10.1111/jfpp.14203.

(44) Fan Meihui, Ding Huafang, Zhang Guowen*, Hu Xing, Gong Deming. (2019). Relationships of dietary flavonoid structure with its tyrosinase inhibitory activity and affinity. LWT, 107, 25–34.

(45) Zhang Peng#, Chen Qian, Fu Guiming, Xia linglin, Hu Xing*. Regulation and metabolic engineering strategies for permeases of Saccharomyces cerevisiae. World Journal of Microbiology and Biotechnology, 2019, 35: 112.

(46) Zhang Peng#, Hu Xing*, Metabolic engineering of arginine permeases to reduce the formation of urea in Saccharomyces cerevisiae. World Journal of Microbiology and Biotechnology, 2018, 34:47.

(47) Zhang Peng#, Li Bang, Wen Peng, Wang Peilin, Yang Yu, Chen Qian, Chang Yuxin, Hu Xing*. Metabolic Engineering of Four GATA Factors to Reduce the Urea and Ethyl Carbamate Formation in a Model Rice Wine System. Journal of Agricultural and Food Chemistry, 2018, 66(41):10881-10889.

(48) Zhang Guowen#, Zhou Zhisheng, Xu Jianjian, Liao Yijing, Hu Xing*. Groove binding between ferulic acid and calf thymus DNA: Spectroscopic methodology combined with chemometrics and molecular docking studies. Journal of Biomolecular Structure and Dynamics, doi: 10.1080/07391102.2019.1624194

(49) Wu Xiaqing#, Ding Huafang, Hu Xing*, Pan Junhui, Liao Yijing, Gong Deming, Zhang Guowen*. Exploring inhibitory mechanism of gallocatechin gallate on a-amylase and aglucosidase relevant to postprandial hyperglycemia. Journal of Functional Foods, 2018, 48:200-209.

（50）胡兴#, 张涛, 沐万孟, 缪铭, 江波*, D-甘露糖异构酶的克隆表达及酶法制备D-甘露糖, 2019. 食品与生物技术学报.

承担课题

1. 国家自然科学基金地区项目 基于TLR4靶向垂钓策略的典型食源性黄酮抑制剂筛选及其改善肠道屏障机制研究 2024年01月 - 2028年12月 主持 在研

2. 江西省自然科学基金面上项目 酸耐受的D-甘露糖异构酶构建及分子机制研究  2024年01月 - 2026年12月 主持 在研

3. 江西省自然科学基金重点项目 基于多固定化策略的D-甘露糖异构酶耐热稳定性和耐弱酸稳定性共适配机制研究 2024年01月 - 2027年12月 主持 在研

4. 国家青年科学基金项目 耐热D-甘露糖异构酶的构建及分子机制研究 2019年01月 - 2021年12月 主持 结题

5. 国家地区基金 油脂微胶囊形成过程中蛋白质-脂质的界面特性及相互作用 2020年01月 - 2023年12月 参与 结题

6. 食品科学与技术国家重点实验室项目 桦木酸对α-葡萄糖苷酶活性和糖基化终末产物形成的抑制作用及机理研究 2017年01月 - 2018年12月 参与 已结题

7. 国家自然科学基金项目 具有潜在致癌性的有机氮农药与DNA的相互作用机制 2012年01月 - 2015年12月 参与 已结题

8. 十二五“863”项目 糖质资源高效生物利用关键技术研究 2013年01月 - 2017年12月 参与 已结题

论文专著

1. Hu Xing, Zhang Peng. Bioprocess Engineering: downstream processing (Chapter 2- Centrifugation), 2019.6, Taylor&Francis Group, editor-in-chief: Show Pau Loke, Ooi Chien Wei, Ling Tau Chuan (国家级，ISBN：9780429466731)；

2. 《食品现代仪器分析》副主编，中国农业出版社，2024年，ISBN: 978-7-109-32094-9