Research Interests:

Mechanisms of aging and screening of bioactive molecules with anti-aging activity.

Major Honors and Professional Service:

Member, Anti-Aging Branch, Chinese Society of Gerontology and Geriatrics

Contact: guishengwu@ncu.edu.cn

Education Experience:

2001–2005  Ph.D. in Zoology, Kunming Institute of Zoology, Chinese Academy of Sciences

1998–2001  M.S. in Animal Genetics and Breeding, Jiangxi Agricultural University

1992–1996 — B.S. in Animal Husbandry, Jiangxi Agricultural University

Global work experience:

Jul 2005 – Oct 2008 — Postdoctoral Researcher, Kansas City Veterans Affairs Medical Center and University of Miami, USA

Research on mechanisms and pharmacology of neuropsychiatric disorders

Work Experience:

Dec 2023 – Present — Research Professor, School of Life Sciences, Nanchang University

Nov 2016 – Mar 2023 — Research Professor, School of Pharmacy, Southwest Medical University

Nov 2008 – Oct 2016 — Associate Research Professor, Kunming Institute of Botany, Chinese Academy of Sciences

Courses Taught:

Human Anatomy and Physiology

Laboratory of Human Anatomy and Physiology

Funded Grants:  

Jan 2018 – Dec 2021 National Natural Science Foundation of China,

Mechanistic study of ubiquitin E3 ligase WWP-1 regulating metabolism and aging via forkhead transcription factor FOXA/PHA-4 in Caenorhabditis elegans

Direct funding: RMB 590,000

Grant No.: 81771516

*Representative Publications (Corresponding author):

Shi L, Yu XT, Li H, Wu GS*, Luo HR*.

D-chiro-inositol increases antioxidant capacity and longevity of Caenorhabditis elegans via activating Nrf-2/SKN-1 and FOXO/DAF-16.

Experimental Gerontology. 2023; 175:112145.

Tan L, Zheng ZY, Huang L, Jin Z, Li SL, Wu GS*, Luo HR*.

Flavonol glycoside complanatoside A requires FOXO/DAF-16, NRF2/SKN-1, and HSF-1 to improve stress resistance and extend lifespan in C. elegans.

Frontiers in Pharmacology. 2022; 13:931886.

Yang ZL, Chen JN, Lu YY, Lu M, Wan QL, Wu GS*, Luo HR*.

Inositol polyphosphate multikinase ipmk-1 regulates development through IP3/calcium signaling in Caenorhabditis elegans.

Cell Calcium. 2021; 93:102327.

Lu M, Tan L, Zhou XG, Yang ZL, Zhu Q, Chen JN, Luo HR*, Wu GS*.

Tectochrysin increases stress resistance and extends lifespan of Caenorhabditis elegans via FOXO/DAF-16.

Biogerontology. 2020; 21(5):669-682.

Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR*.

Chlorogenic acid extends lifespan of Caenorhabditis elegans via insulin/IGF-1 signaling pathway.

Journal of Gerontology A: Biological Sciences & Medical Sciences. 2017; 72(4):464-472.

Pu YZ, Wan QL, Ding AJ, Luo HR*, Wu GS*.

Quantitative proteomics analysis of Caenorhabditis elegans upon germ cell loss.

Journal of Proteomics. 2017; 156:85-93.

• 2001-2005 Kunming Institute of Zoology, Chinese Academy of Sciences Ph.D
• 1998-2001 Jiangxi Agricultural University M.S.
• 1992-1996 Jiangxi Agricultural University B.S.

• [1] Dec 2023-* Research Professor School of Life Sciences, NanchangUniversity
• [2] Nov 2016-Mar 2023 Research Professor School of Pharmacy, SouthwestMedical University
• [3] Nov 2008-Oct 2016 Associate Research Professor Kunming Institute ofBotany, Chinese Academy of Sciences