学科方向：食品科学与工程

所属院系：食品学院

研究方向

1. 膳食营养组分与宿主代谢，主要涉及肥胖，糖尿病，非酒精性脂肪肝炎。

2. 膳食纤维与肠道共生菌调控，主要涉及膳食纤维影响的肠道有益菌，细菌互作。

3. 菌源活性代谢物与宿主健康，主要涉及肠道菌的新型活性代谢物，代谢物改善宿主稳态的分子机制探究。

讲授课程

本科生课程：《食品生物化学》

研究生课程：《肠道微生物和人体健康》

学术成就

主持省级人才项目、国家自然科学基金和重点研发计划子课题等多项项目；以第一/共一作者在Cell、Nature Communications、Advanced Science、iMeta、Food Hydrocolloids、Food Chemistry、Carbohydrate Polymers等期刊发表论文十余篇；以共同作者在Nature、Science、Cell Metabolism等期刊发表多篇高水平论文。

承担课题

1、国家自然科学基金青年基金，2023年1月-2025年12月，30万元，主持

2、国家重点研发计划子课题，2024年1月-2027年12月，90万元，主持

3、江西省赣鄱俊才支持计划·青年科技人才托举项目，2023年12月-2026年11月，80万元，主持

论文专著

1. Nie Q, Luo X, Wang K, Ding Y, Jia S, Zhao Q, Li M, Zhang J, Zhuo Y, Lin J, Guo C, Zhang Z, Liu H, Zeng G, You J, Sun L, Lu H, Ma M, Jia Y, Zheng MH, Pang Y, Qiao J, Jiang C. Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway. Cell. 2024. 187(11):2717-2734.

2. Wang K, Zhang Z, Hang J, Liu J, Guo F, Ding Y, Li M, Nie Q, Lin J, Zhuo Y, Sun L, Luo X, Zhong Q, Ye C, Yun C, Zhang Y, Wang J, Bao R, Pang Y, Wang G, Gonzalez FJ, Lei X, Qiao J, Jiang C. (2023). Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target. Science. 381(6657):eadd5787.

3. Chen B, Sun L, Zeng G, Shen Z, Wang K, Yin L, Xu F, Wang P, Ding Y, Nie Q, Wu Q, Zhang Z, Xia J, Lin J, Luo Y, Cai J, Krausz KW, Zheng R, Xue Y, Zheng MH, Li Y, Yu C, Gonzalez FJ, Jiang C.  (2022). Gut bacteria alleviate smoking-related NASH by degrading gut nicotine. Nature. 610(7932):562-568.
4. Nie Q, Sun Y, Hu W, Chen C, Lin Q, Nie S. (2023). Glucomannan promotes Bacteroides ovatus to improve intestinal barrier function and ameliorate insulin resistance. iMeta. e163.

5. Sun Y#, Nie Q#, Zhang S, He H, Zuo S, Chen C, Yang J, Chen H, Hu J, Li S, Cheng J, Zhang B, Zheng Z, Pan S, Huang P, Lian L, Nie S. (2023). Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a. Nature Communications. 14(1):7740.

6. Liu H#, Wang P#, Xu F#, Nie Q#, Yan S, Zhang Z, Zhang Y, Jiang C, Qin X, Pang Y. (2024). The Hydrophilic Metabolite UMP Alleviates Obesity Traits through a HIF2α-ACER2-Ceramide Signaling Axis. Advanced Science. e2309525. doi: 10.1002/advs.202309525.

7. Nie Q, Sun Y, Li M, Zuo S, Chen C, Lin Q, Nie S. (2023). Targeted modification of gut microbiota and related metabolites via dietary fiber. Carbohydrate Polymers. 316:120986.

8. Nie Q., Hu J., Chen H., Geng F., Nie S. (2022). Arabinoxylan ameliorates type 2 diabetes by regulating the gut microbiota and metabolites. Food Chemistry. 371:131106.

9. Nie Q, Hu J, Gao H, Li M, Sun Y, Chen H, Zuo S, Fang Q, Huang X, Yin J, Nie S. (2021). Bioactive Dietary Fibers Selectively Promote Gut Microbiota to Exert Antidiabetic Effects. Journal of Agricultural and Food Chemistry. 69(25):7000-7015.

10. Li, Q#, Hu, J#, Nie, Q#, Chang, X#, Fang, Q, ... & Nie, S. (2020). Hypoglycemic mechanism of polysaccharide from Cyclocarya paliurus leaves in type 2 diabetic rats by gut microbiota and host metabolism alteration. SCIENCE CHINA Life Sciences. 64(1):117-132.

11. Nie, Q, Xing, M, Chen, H, Hu, J, & Nie, S. (2019). Metabolomics and Lipidomics Profiling Reveals Hypocholesterolemic and Hypolipidemic Effects of Arabinoxylan on Type 2 Diabetic Rats. Journal of Agricultural and Food Chemistry. 67(38):10614-10623. 

12. Nie, Q, Chen, H, Hu, J, Tan, H, Nie, S, & Xie, M. (2020). Effects of Nondigestible Oligosaccharides on Obesity. Annual Review of Food Science and Technology. 11:205-233.

13. Nie, Q, Hu, J, Gao, H, Fan, L, Chen, H, & Nie, S. (2019). Polysaccharide from Plantago asiatica L. attenuates hyperglycemia, hyperlipidemia and affects colon microbiota in type 2 diabetic rats. Food Hydrocolloids. 86:34-42. 

14. Nie, Q, Chen, H, Hu, J, Fan, S, & Nie, S. (2019). Dietary compounds and traditional Chinese medicine ameliorate type 2 diabetes by modulating gut microbiota. Critical Reviews in Food Science and Nutrition. 59(6): 848-863. 

15. Nie, Q, Chen, H, Hu, J, Gao, H, Fan, L, Long, Z, & Nie, S. (2018). Arabinoxylan attenuates type 2 diabetes by improvement of carbohydrate, lipid, and amino acid metabolism. Molecular Nutrition & Food Research. 62(20):1800222. 

16. Wang X, Zhou S, Hu X, Ye C, Nie Q, Wang K, Yan S, Lin J, Xu F, Li M, Wu Q, Sun L, Liu B, Zhang Y, Yun C, Wang X, Liu H, Yin WB, Zhao D, Hang J, Zhang S, Jiang C, Pang Y. Candida albicans accelerates atherosclerosis by activating intestinal hypoxia-inducible factor2α signaling. Cell Host & Microbe. 2024. 32(6):964-979.

17. Wu Q., Liang X., Wang K., Lin J., Wang X., Wang P., Zhang Y., Nie Q., Liu H., Zhang Z., Liu J., Pang Y., Jiang C. (2021). Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis. Cell Metabolism. 33(10):1988-2003. 

18. Yun C, Yan S, Liao B, Ding Y, Qi X, Zhao M, Wang K, Zhuo Y, Nie Q, Ye C, Xia P, Ma M, Li R, Jiang C, Qiao J, Pang Y. The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice. Nature Metabolism. 2024. 6(5):947-962.

19. Xia J, Chen H, Wang X, Chen W, Lin J, Xu F, Nie Q, Ye C, Zhong B, Zhao M, Yun C, Zeng G, Mao Y, Wen Y, Zhang X, Yan S, Wang X, Sun L, Liu F, Zhong C, Xia P, Jiang C, Rao H, Pang Y. Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α. Nature Communications. 2024. 15(1):4755.