CN Login Home

Personal Information

E-mail:huairongluo@ncu.edu.cn


EDUCATION

2003 Ph.D. of Zoology (major in pharmacogenetics), Kunming Institute of Zoology, CAS

1998 B.S. of Biochemistry, Lanzhou University 


RESEARCH EXPERIENCE

2016.11--Present Key Laboratory for Aging and Regenerative Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University

   (1) Mechanism of aging and neuropsychiatric disorders;

   (2) Drug screening for aging and age-related diseases.


2008.5—2019.6 Principal Investigator in Kunming Institute of Botany, CAS

   (1) Mechanism of aging and neuropsychiatric disorders;

   (2) Genetics and pharmacology for ligands of ion channels;

   (3) Chemical genetics of Traditional Chinese Medicine (TCMs) against neuropsychiatric disease and aging.


2013.11--2014.3 Visiting scientist in Department of Integrative Biology and Pharmacology,

The University of Texas Health Science Center at Houston

   (1) Molecular mechanism of regulation of TRPC channels;

   (2) High throughput screening of TRPC ligands.


2010.1--2010.3 Visiting scientist in Department of Biological Sciences, Columbia University

   (1) Regulation of voltage-gated calcium channels;

   (2) Regulation of TRP channels.


2007.3--2008.8 Postdoctoral research associate in Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine 

(1) Clinical pharmacogenomics of antidepressant drug action;

(2) Genetics of human obesity.


2004.1--2007.2 Postdoctoral fellow in Pharmacology and Toxicology Program, Department of Pharmacology, University of Kansas Medical Center

 (1) Clinical pharmacogenetics in neuropsychiatric diseases;

 (2) Ethnic variations in antidepressant response. 


1998.9--2003.12 Graduate student dissertation projects at Kunming Institute of Zoology, CAS

 (1) Pharmacogenetics in cancer treatment and alcoholism;

 (2) Association study in systemic lupus erythematosus in Chinese population. 


HONORS AND AWARDS

2011  Hundred Overseas Talent Program Recruitment granted by the Government of Yunnan Province, China.

2008  Hundred Overseas Talent Program Recruitment granted by the Chinese Academy of Sciences, China.

2005  Junior Investigator Award, 28th Research Society on Alcoholism meeting, Santa Barbara, CA, granted by National Institute on Alcohol Abuse and Alcoholism.

2004  The third class award of Science and Technology Progress granted by the Government of Yunnan Province, China.

2002.8 Scholarship and Travel Award, Recent Advances in Conservation Genetics Course, Front Royal, VA, granted by American Genetic Association.

1994.9-1998.7 Scholarship, Lanzhou University, Gansu, China, granted by the Ministry of Education of China.


FUNDED GRANT

2017-2020 “Mechanism of reproductive system on lifespan regulation in Caenorhabditis elegans” funded by National Natural Science Foundation of China, ￥650,000; PI: Luo HR.

2014-2017 “Mechanism of antiaging in Caenorhabditis elegans by aspirin” funded by National Natural Science Foundation of China, ￥700,000; PI: Luo HR.

2014-2016 “Research on the durability of TRPC4/5 channel inhibitor M084 as antidepressant” funded by Government of Yunnan Province, China, ￥800,000; PI: Luo HR.

2012-2015 “Drug discovery of neuropsychiatric diseases” funded by Government of Yunnan Province, China, ￥1M; PI: Luo HR.

2011-2014 “Drug Screening and Research for Neuropsychological Diseases” funded by Chinese Academy of Sciences, ￥2M; PI: Luo HR.

2010-2012 “Studies on the chemical constituents of three species of the family Ericaceae and their bioactivity” funded by State Key Laboratory of Phytochemistry and Plant Resources in West China, KIB, CAS, ￥100,000; PI: Li RT, (Co)PI: Luo HR.

2009-2011 “Construction of cellular models for drug screening of neuropsychological diseases” funded by State Key Laboratory of Phytochemistry and Plant Resources in West China, KIB, CAS, ￥250,000; PI: Luo HR.

2008-2013 “Molecular mechanism of antipsychotic natural products in Yunnan Province” funded by the Department of Science and Technology in Yunnan Province, ￥2.4M; PI: Luo HR.

2008-2013 “Drug screening andresearch for neurological and mental diseases”funded by Kunming Institute of Botany, CAS, ￥730,000; PI: Luo HR.

2004-2005 “Nicotine pharmacogenomics and depression in four major ethnic groups” funded by the University of Kansas Medical Center, $16,000, PI: Luo HR. 


PUBLICATIONS

Published Papers (*: Corresponding author)

1. Yang ZL, Lu M, Wan QL, Wu GS*, Luo HR*. IPMK-1 regulate development through calcium signaling. BMC Biology. 2019; under review.

2. Zhu Q, Qu Y, Zhou XG, Chen JN, Luo HR*, Wu GS*. A dihydroflavonoid naringin extends the lifespan of C. elegans and delays the progression of ageing-related diseases in PD/AD Models via DAF-16. Oxid Med Cell Longev. 2020; e6069354.

3. Lu M, Tan L, Zhou XG, Yang ZL, Zhu Q, Chen JN, Luo HR*, Wu GS*. Secoisolariciresinol diglucoside delays the progression of aging-related diseases and extends the lifespan of Caenorhabditis elegans via DAF-16 and HSF-1. Oxid Med Cell Longev. 2020; e1293935.

4. Lu M, Tan L, Zhou XG, Yang ZL, Zhu Q, Chen JN, Luo HR*, Wu GS*. Tectochrysin increases stress resistance and extends the lifespan of Caenorhabditis elegans via FOXO/DAF-16. Biogerontology. 2020; 21(5): 669-682.

5. Lan X, Kumar V, Jha A, Aslam R, Wang H, Chen K, Yu Y, He W, Chen F, Luo H, Malhotra A, Singhal PC. EDA2R mediates podocyte injury in high glucose milieu. Biochimie. 2020; 174: 74-83.

6. Lee MH, Luo HR, Bae SH, San-Miguel A. Genetic and chemical effects on somatic and germline aging. Oxid Med Cell Longev. 2020; e4684890.

7. Wan QL, Yang ZL, Zhou XG, Ding AJ, Pu YZ, Luo HR, Wu GS*. The effects of age and reproduction on the lipidome of Caenorhabditis elegans. Oxid Med Cell Longev. 2019; e5768953.

8. Guo Y*, Xie JP, Deng K, Li X, Yuan Y, Xuan Q, Xie J, He XM, Wang Q, Li JJ, Luo HR*. Prophylactic effects of Bifidobacterium adolescentis on anxiety and depression-like phenotypes after chronic stress: a role of the gut microbiota-inflammation axis. Front Behav Neurosci. 2019; e00126.

9. Deng K, Yang L, Xie J, Tang H, Wu GS, Luo HR*. Whole-brain mapping of projection from mice lateral septal nucleus. Biology Open, 2019, 8(7): bio.043554.

10. Huang XB, Wu GS, Ke LY, Zhou XG, Wang YH*, Luo HR*. Aspirin derivative 5-(Bis(3-methylbut-2-enyl)amino)-2-hydroxybenzoic acid improves thermotolerance via stress response proteins in Caenorhabditis elegans. Molecules. 2018;23(6): e1359.

11. Wen H, Kumar V, Mishra A, Song S, Aslam R, Hussain A, Wang H, Zhou X, He X, Wu G, Luo H, Lan X, Malhotra A, Singhal PC. Grem2 mediates podocyte apoptosis in high glucose milieu. Biochimie. 2019; 160: 113-121.

12. Ding M, Wang H, Qu C, Xu F, Zhu Y, Lv G, Lu Y, Zhou Q, Zhou H, Zeng X, Zhang J, Yan C, Lin J, Luo HR, Deng Z, Xiao Y, Tian J, Zhu MX, Hong X. Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer. Cancer Lett. 2018; 432:47-55.

13. Zheng SQ, Huang XB, Xing TK, Ding AJ, Wu GS, Luo HR*. Chlorogenic acid extends the lifespan of Caenorhabditis elegans via insulin/IGF-1 signaling pathway. J Gerontol A Biol Sci Med Sci. 2017;72(4):464-472.

14. Wan QL, Shi X, Liu J, Ding AJ, Pu YZ, Li Z, Wu GS*, Luo HR*. Metabolomic signature associated with reproduction-regulated aging in Caenorhabditis elegans. Aging-US. 2017; 9(2): 447-474.

15. Pu YZ, Wan QL, Ding AJ, Luo HR*, Wu GS*. Quantitative proteomics analysis of Caenorhabditis elegans upon germ cell loss. J Proteomics. 2017; 156: 85-93.

16. Ding AJ, Wu GS, Tang B, Hong X, Zhu MX, Luo HR*. Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem. 2017; 426(1-2): 101-109.

17. Huang XB, Mu XH, Wan QL, He XM, Wu GS, Luo HR*. Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PLoS One. 2017;12(9):e0184027.

18. Yang J, Huang XB, Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH, Luo HR*. Otophylloside B protects against Aβ toxicity in Caenorhabditis elegans models of Alzheimer's disease. Nat Prod Bioprospect. 2017;7(2):207-214.

19. Qu C, Ding M, Zhu Y, Lu Y, Du J, Miller M, Tian J, Zhu J, Xu J, Wen M, Er-Bu A, Wang J, Xiao Y, Wu M, McManus OB, Li M, Wu J, Luo HR, Cao Z, Shen B, Wang H, Zhu MX, Hong X. Pyrazolopyrimidines as potent stimulators for transient receptor potential canonical 3/6/7 channels. J Med Chem. 2017;60(11):4680-4692.

20. Ding AJ, Zheng SQ, Huang XB, Xing TK, Wu GS, Sun HY, Qi SH, Luo HR*. Current perspective in the discovery of anti-aging agents from natural products. Nat Prod Bioprospect. 2017; 7(5): 335-404.

21. Tang H, Wu GS, Xie J, He X, Deng K, Wang H, Xu F*, Luo HR*. Brain-wide map of projections from mice ventral subiculum. Neurosci Lett. 2016; 629: 171-9.

22. Yang LP, Jiang FJ, Wu GS, Deng K, Wen M, Zhou X, Hong X, Zhu MX, Luo HR*. Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One. 2015; 10(8):e0136255.

23. Zhu Y, Lu Y, Qu C, Miller M, Tian J, Thakura DP, Zhu J, Deng Z, Hu X, Wu M, McManus OB, Li M, Hong X*, Zhu MX*, Luo HR*. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol. 2015; 172(14):3495-509.

24. Yang J, Wan QL, Mu QZ, Wu CF, Ding AJ, Yang ZL, Qiu MH, Luo HR*. The lifespan-promoting effect of otophylloside B in Caenorhabditis elegans. Nat Prod Bioprospect. 2015; 5(4):177-83.

25. Dong FW, Wu ZK, Yang L, Zi CT, Yang D, Ma RJ, Liu ZH, Luo HR, Zhou J, Hu JM. Iridoids and sesquiterpenoids of Valeriana stenoptera and their effects on NGF-induced neurite outgrowth in PC12 cells. Phytochemistry. 2015;118: 51-60.

26. Gu CZ, Lv JJ, Zhang XX, Qiao YJ, Yan H, Li Y, Wang D, Zhu HT, Luo HR, Yang CR, Xu M, Zhang YJ. Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng. J Nat Prod. 2015;78(8):1829-40.

27. Gu CZ, Lv JJ, Zhang XX, Yan H, Zhu HT, Luo HR, Wang D, Yang CR, Xu M, Zhang YJ. Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng. Fitoterapia. 2015;103:97-105.

28. Dong FW, Liu Yang, Wu ZK, Wei-Gao, Zi CT, Dan Yang, Luo HR, Jun Zhou, Hu JM. Iridoids and sesquiterpenoids from the roots of Valeriana jatamansi Jones. Fitoterapia. 2015;102:27-34.

29. Yang L, Liu SJ, Luo HR, Cui J, Zhou J, Wang XJ, Sheng J, Hu JM. Two new dendrocandins with neurite outgrowth-promoting activity from Dendrobium officinale. J Asian Nat Prod Res. 2015;17(2):125-131.

30. Yuan XX, Yang LP, Yang ZL, Xiao WL*, Sun HD, Wu GS, Luo HR*. Effect of nigranoic acid on Ca2+ influx and its downstream signal mechanism in NGF-differentiated PC12 cells. J Ethnopharmacol. 2014; 153(3): 725-731.

31. Wei JF, Wang YQ, Luo HR. Drug-related genomics in cancer and immunological diseases. Int J Genomics. 2014; 306980.

32. He J, Wu XD, Liu F, Liu YC, Peng LY, Zhao Y, Cheng X, Luo HR, Zhao QS. Lycopodine-Type Alkaloids from Lycopodium japonicum. Nat Prod Bioprospect. 2014; 4(4): 213-9.

33. Wan QL, Zheng SQ, Wu GS, Luo HR*. Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway. Exp Gerontol. 2013; 48(5): 499-506.

34. Zheng SQ, Ding AJ, Li GP, Wu GS, Luo HR*. Drug absorption efficiency in Caenorhbditis elegans delivered by different methods. PLoS One. 2013; 8(2): e56877.

35. Zhu J, Wu CF, Li X, Wu GS, Xie S, Hu QN, Deng Z, Zhu MX*, Luo HR*, Hong X*. Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2013; 21(14):4218-24.

36. Zhang SS, Ma QY, Zou XS, Dai HF, Huang SZ, Luo Y, Yu ZF, Luo HR*, Zhao YX*. Chemical constituents from the Fungus Amauroderma amoiensis and their in vitro acetylcholinesterase inhibitory activities. Planta Med. 2013; 79(1): 87-91.

37. Wang WG, Wu ZY, Chen R, Li HZ, Li HM, Li YD, Li RT*, Luo HR*. Pierisformotoxins A–D, polyesterified grayanane diterpenoids from Pieris formosa and their cAMP-decreasing activities. Chem Biodivers. 2013; 10(6):1061-71.

38. Liu B, Yang L, Xu YK, Liao SG, Luo HR, Na Z. Two new triterpenoids from Gelsemium elegans and Aglaia odorata. Nat Prod Commun. 2013; 8(10): 1373-6.

39. Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C, Han C, Tang TS. Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease. Hum Mol Genet. 2013; 15;22(18):3641-53.

40. Wang PC, Ran XH, Luo HR, Ma QY, Liu YQ, Dai HF, Zhou J, Zhao YX. Volvalerenol A, a New Triterpenoid with a 12-Membered Ring from Valeriana hardwickii. Org Lett. 2013; 15(12):2898-901.

41. Peng XR, Liu JQ, Han ZH, Yuan XX, Luo HR, Qiu MH. Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells. Food Chem. 2013; 141(2):920-6.

42. Dong C, Liu L, Li X, Guan Z, Luo H, Wang Y. Sesquineolignans and terpene-sesquineolignans: anti-Acetylcholinesterase constituents from Illicium simonsii. Planta Med. 2013; 79(5):338-47.

43. Dong FW, Luo HR, Wan QL, Xu FQ, Fan WW, Wang KJ, Li N, Hu JM. Two new bibenzyl glucosides from Dendrobium chrysotoxum. B Korean Chem Soc. 2012; 33(7): 2247-50.

44. Shang SZ, Kong LM, Yang LP, Jiang J, Huang J, Zhang HB, Shi YM, Zhao W, Li HL, Luo HR, Li Y, Xiao WL, Sun HD. Bioactive phenolics and terpenoids from Manglietia insignis. Fitoterapia. 2013; 84: 58-63.

45. Xu F, Wang C, Yang L, Luo HR, Fan W, Zi C, Dong F, Hu J, Zhou J. C-dideoxyhexosyl flavones from the stems and leaves of Passiflora edulis Sims. Food Chem. 2013; 136(1): 94-9.

46. Wang YH, Wan QL, Gu CD, Luo HR, Long CL. Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase. Chem Cent J. 2012; 6(1): 96.

47. Dong LB, Yang J, He J, Luo HR, Wu XD, Deng X, Peng LY, Cheng X, Zhao QS. Lycopalhine A, a novel sterically congested Lycopodium alkaloid with an unprecedented skeleton from Palhinhaea cernua. Chem Commun. 2012; 48(72): 9038-40.

48. Yan YM, Wu GS, Dong XP, Shen L, Li Y, Su J, Luo HR, Zhu HJ, Cheng YX. Sesquiterpenoids from Incarvillea arguta: absolute configuration and biological evaluation. J Nat Prod. 2012; 75(6): 1025-9.

49. Yang XW, Deng X, Liu X, Wu CY, Li XN, Wu B, Luo HR, Li Y, Xu HX, Zhao QS, Xu G. Hypercohin A, a new polycyclic polyprenylated acylphloroglucinol possessing an unusual bicyclo[5.3.1]hendecane core from Hypericum cohaerens. Chem Commun. 2012; 48:5998-6000.

50. Liu JQ, Wang CF, Li Y, Luo HR, Qiu MH. Isolation and bioactivity evaluation of terpenoids from the medicinal fungus Ganoderma sinense. Planta Med. 2012; 78(4): 368-76.

51. Wu ZY, Li HZ, Wang WG, Li HM, Chen R, Li RT*, Luo HR*. Lyonin A, a new 9,10-seco grayanotoxin from Lyonia ovalifolia. Chem Biodivers. 2011; 8(6): 1182-7.

52. Wang PC, Ran XH, Chen R, Luo HR, Ma QY, Liu YQ, Hu JM, Huang SZ, Jiang HZ, Chen ZQ, Zhou J, Zhao YX. Sesquiterpenoids and lignans from the roots of Valeriana officinalis L. Chem Biodivers. 2011; 8(10): 1908-13.

53. Wang PC, Ran XH, Luo HR, Hu JM, Chen R, Ma QY, Dai HF, Liu YQ, Xie MJ, Zhou J, Zhao YX. Volvalerelactones A and B, two new sesquiterpenoid lactones with an unprecedented skeleton from Valeriana officinalis var. latifolia. Org Lett. 2011; 13(12): 3036-9.

54. Wu ZY, Li YD, Wu GS, Luo HR, Li HM, Li RT. Three new highly acylated 3,4-seco-grayanane diterpenoids from the fruits of Pieris Formosa. Chem Pharm Bull. 2011; 59(4): 492-5.

55. Zhu X, Wu G, Xiang J, Luo HR, Luo S, Zhu H, Wang Y. New pregnane saponins from Ecdysanthera rosea and their cytotoxicity. Fitoterapia. 2011; 82(4):632-6.

56. Jia L, Cheng H, Wang H, Luo HR, Yan H. From shake flasks to bioreactors: survival of E. coli cells harboring pGST-hPTH through auto-induction by controlling initial content of yeast extract. Appl Microbiol Biotechnol. 2011; 90(4): 1419-28.

57. Wu GS, Luo HR, Dong C, Mastronardi C, Licinio J, Wong ML. Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response. Psychiatr Genet. 2011; 21(1): 14-8.

58. Fan M, Buraei Z, Luo HR, Levenson-Palmer R, Yang J. Direct inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavbeta interaction. Proc Natl Acad Sci U S A, 2010; 107(33):14887-92.

59. Wang PC, Ran XH, Chen R, Li LC; Xiong SS, Liu, Liu YQ, Luo HR, Zhou J, Zhao YX. Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis. Tetrahedron Lett. 2010; 51(41):5451-3.

60. Wang PC, Ran XH, Chen R, Luo HR, Liu YQ, Zhou J, Zhao YX. Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia. J Nat Prod. 2010; 73(9):1563-7.

61. Miao Y, Wu G, Wang L, Li D, Tang S, Liang J, Mao H, Luo HR, Zhang Y. The role of MC1R gene in buffalo coat color. Sci China Life Sci. 2010; 53(2): 267-72.

62. Tong XG, Wu GS, Huang CG, Lu Q, Wang YH, Long CL, Luo HR, Zhu HJ, Cheng YX. Compounds from Acorus tatarinowii: determination of the absolute configurations by quantum computation and cAMP regulation activity. J Nat Prod. 2010; 73(6): 1160-3.

63. Yan J, Sun L, Wu G, Yi P, Yang F, Zhou L, Zhang X, Li Z, Yang X, Luo HR, Qiu M. Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives. Bioorg Med Chem. 2009; 17(19):6937-41.

64. Luo HR, Wu GS, Pakstis AJ, Tong L, Oota H, Kidd KK, and Zhang YP. Origin and dispersal of atypical aldehyde dehydrogenase ALDH2*487Lys. Gene. 2009; 435: 96–103.

65. Luo HR, Wu GS, Dong C, Arcos-Burgos M, Ribeiro L, Licinio J, and Wong ML. Association of PDE11A global haplotype with major depression and antidepressant drug response. Neuropsychiatric Disease and Treatment, 2009; 5: 163-70.

66. Esposito K, Reierson GW, Luo HR, Wu GS, Licinio J, and Wong ML. Phosphodiesterase genes and antidepressant treatment response. Annals of Medicine. 2009; 41(3):177-85.

67. Jow H, Amos W, Luo HR, Zhang Y, Burroughs NJ. A Markov chain Monte Carlo method for estimating population mixing using Y-chromosome markers: mixing of the Han people in China. Annals of Human Genetics, 2007; 71(3): 407-20.

68. Luo HR, Poland RE, Lin KM, and Wan YJ. Genetic polymorphism of cytochrome P450 2C19 in Mexican Americans: a cross-ethnic comparative study. Clinical Pharmacology & Therapeutics. 2006; 80(1): 33-40.

69. Luo HR and Wan YJ. Polymorphisms of genes encoding phase I enzymes in Mexican Americans-an ethnic comparison study. Current Pharmacogenomics (now named as Current Pharmacogenomics and Personalized Medicine). 2006; 4(4): 345-53.

70. Luo HR, Konishi T, Tsuang J, and Wan YJ. Comparison of alcohol drinking behaviors and associated problems between benders and nonbenders in Mexican Americans who drink excessively. Addictive Disorders & Their Treatment. 2006; 5(3): 121-27.

71. Wang K, Mendy AJ, Dai G, Luo HR, He L, and Wan YJ. Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicological Sciences, 2006; 92(1): 51-60.

72. Luo HR, Gaedigk A, Aloumanis V, and Wan YJ. Identification of CYP2D6 impaired functional alleles in Mexican Americans. European Journal of Clinical Pharmacology. 2005; 61(11): 797-802.

73. Luo HR, Hou ZF, Wu J, Zhang YP, and Wan YJ. Evolution of the DRD2 gene haplotype and its association with alcoholism in Mexican Americans. Alcohol. 2005; 36(2): 117-25.

74. Luo HR, Israel Y, Tu GC, Eriksson CJP, and Zhang YP. Genetic polymorphism of aldehyde dehydrogenase in Chinese: gender, age, culture and genotypes of ALDH2. Biochemical Genetics. 2005; 43 (5/6): 223-7.

75. Luo HR, Aloumanis V, Lin KM, Gurwitz D, and Wan YJ. Polymorphisms of CYP2C19 and CYP2D6 in Israeli ethnic groups. American Journal of PharmacoGenomics (now as Molecular Diagnosis & Therapy). 2004; 4(6): 395-401.

76. Zhang YW, Luo HR, Ryder OA, and Zhang YP. Evolution of the tandem repeats in thymidylate synthase enhancer region (TSER) in primates. Gene. 2004; 338(1): 47-54.

77. Konishi T, Luo HR, Calvillo M, Mayo M, Lin KM, and Wan YJ. ADH1B*1, ADH1C*2, DRD2 (-141C Ins) and 5-HTTLPR are associated with alcoholism in Mexican American Men living in Los Angeles. Alcoholism: Clinical and Experimental Research. 2004; 28(8): 1145-52.

78. Luo HR, Zhang YP. Aldehyde dehydrogenase (ALDH2) polymorphism and drinking behavior. Hereditas (Beijing). 2004; 26(2): 263-6. (Review)

79. Li H, Luo HR, Zhang YP, Qiu XP, Ye C. Detection and typing for swine leukocyte antigen. Hereditas (Beijing), 2004; 26(2): 211-4.  

80. Man XY, Yao YG, Li XP, Luo HR, Mao CZ, Zhang YP. 2004. The relation between the deficiency of complement protein C2 type I and systemic lupus erythematosus in Yunnan people. Chinese Journal of Dermatology, 37(2): 115.

81. Man XY, Luo HR, Li XP, Yao YG, Mao MC, Zhang YP. Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese. Annals of the rheumatic diseases. 2003; 62(1): 71-3.

82. Luo HR, Lü XM, Yao YG, Horie N, Takeishi K, Jorde LB, and Zhang YP. Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel alleles. Biochemical Genetics. 2002; 40(1-2): 41-51.

83. Luo HR, Tu GC, and Zhang YP. Detection of usual and atypical aldehyde dehydrogenase alleles by mismatch amplification mutation assay. Clinical Chemistry and Laboratory Medicine. 2001; 39(12): 1195-7.

84. Luo HR, Shi P, Zhang YP. 2001. Detection for single nucleotide polymorphisms. Hereditas (Beijing). 2001; 23: 471-476. (Review) 

85. Shi P, Lü XM, Luo HR, Xiang-Yu JG, and Zhang YP. Melanocortin-1 receptor gene variants in four Chinese ethnic populations. Cell Research, 2001; 11(1): 81-4.

86. Yao YG, Lü XM, Luo HR, Li WH, and Zhang YP. Gene admixture in the silk road region of China: evidence from mtDNA and melanocortin 1 receptor polymorphism. Genes & Genetic Systems. 2000; 75(4): 173-178. 


Patents:

1. Luo HR, Hong X, Zhu MX, Zhu J, Wu GS, Deng Z, Zhu Y, Lu Y, Deng K, Qu C. The therapeutics usage for a pyrimidine and its analogs. Patent: ZL201310666552.1.

2. Luo HR, Hong X, Deng Z, Wu GS, Yang LP, Zhu JM, Liu L. Anti-depression of a benzimidazole and its analogs. Patent: ZL201210512505.7.

3. Qiu MH, Luo HR, Sun Y, Zhou L, Hu YK, Wu GS. The therapeutics usage for a steroid alkaloid and its analogs. Patent: ZL201110235562.0.

 

Conference Posters:

1. Ding AJ, Zheng SQ, Wan QL, Luo HR*. Compound T-856 extends lifespan of the Nematode Caenorhabditis elegans. The Second World Conference on the Pharmacology of Natural and Traditional Medicines. November 6-8, 2012, Macau, China, Poster No: 16.

2. Zheng SQ, Wu GS, Ding AJ, Wan QL, and Luo HR*. 2011. The compound L-211 extends the lifespan of C. elegans. The 2nd Chinese C. elegans Meeting, November 18-20, 2011, Beijing, China, Poster No: 36.

3. Luo HR, Wu GS, Ribeiro L, Licinio J, and Wong ML. 2007. Association of PDE11A global haplotype with major depression and outcome of antidepressant treatment. 57th Annual Meeting of the American Society of Human Genetics, October 23-27, 2007, San Diego, California, USA, Poster No: 1839.

4. Wu GS, Luo HR, Zhang YP. 2007. Origin of aldehyde dehydrogenase ALDH2*2 and its demographic implication. 57th Annual Meeting of the American Society of Human Genetics, October 23-27, 2007, San Diego, California, USA, Poster No: 1299.

5. Luo HR, Reimer GN, and Wan YJ. 2006. Mu opioid receptor A118G polymorphism is associated with alcoholism in a Mexican American population. Central State Society of Toxicology Annual Meeting, October 5-6, Kansas City, KS,USA, Poster No: 4.

6. Luo HR, Hou ZF, Wu J, Zhang YP, and Wan YJ. 2005. Evolution of the DRD2 gene haplotype and its association with alcoholism in Mexican Americans. 28th Annual Scientific Meeting of the Research Society on Alcoholism, June 25-30, 2005, Santa Barbara, California, USA, Poster No: 26. (Received Junior Investigator Award)

7. Luo HR, Konishi T, Tsuang J, and Wan YJ. 2005. Comparison of alcohol drinking behaviors and associated problems between Mexican American benders and non-benders. 28th Annual Scientific Meeting of the Research Society on Alcoholism, June 25-30, 2005, Santa Barbara, California, USA, Poster No: 174.

8. Luo HR, Zhang YW, and Zhang YP. 2002. Length variation of thymidylate synthase enhancer region (TSER) and their evolution in primates. 7th International Human Genome Meeting, April 14-17, 2002, Shanghai, China, Poster No: 558. 


Educational Experience

More >

Work Experience

More >

Research Project

. . . More >