学科方向：食品安全

所属院系：食品学院

研究方向

1.食品安全快速检测

2.医学体外诊断技术

3.微纳米材料开发及分析化学应用

讲授课程

1.《食品安全学》

2.《食品质量控制与安全监管》

学术成就

近年来，本人针对食品安全快速检测灵敏度低、定量不准、稳定性差等“瓶颈”问题，大量开展了基于新型信号传导的免疫学检测方法的基础理论及应用研究。期间主持及参与国家自然科学基金、国家重点研发计划项目、江西省自然科学基金项目等十余项省部级课题研究，发表SCI收录论文40余篇，其中以第一或通讯作者（含共同）在Chem Soc Rev., Adv Funct Mater., Adv Sci.,等国际权威杂志发表SCI 收录论文20余篇，获授权国家发明专利2 件，研究成果获2021年度江西省自然科学奖一等奖（排名第5）。另外，主持或参与省级教改课题两项，作为第一指导老师指导项目荣获中国国际“互联网+”大学生创新创业大赛全国银奖、铜奖各1项。

承担课题

1. 国家自然科学基金面上项目：基于可逆界面传质调控机制的AChE固定化荧光传感器及有机磷农药高灵敏抗干扰速测（No.32372427），主持，50万，2024.01-2027.12

2. 国家自然科学基金青年项目：基于点击化学介导金纳米簇聚集发光增强的超灵敏无酶免疫分析新方法 （No.31901780），主持，24万，2020.01-2022.12 

3. 江西省赣鄱俊才支持计划——主要学术学科和技术带头人项目：AChE固定化可逆超浸润荧光水凝胶及有机磷农药高灵敏抗干扰快检（编号：20232BCJ23020）主持，30万, 2023.07-2026.06

4. 2023.07-2026.07江西省自然科学基金青年项目：基于酶催化磁性荧光探针原位沉积的食源性致病菌液相生物芯片技术（编号：20232BAB216100 ）主持，10万, 2023.07-2026.06

5.南昌大学青年人才培育创新基金项目（自然科学类）,主持，20万, 2023.07-2026.06

论文专著

部分代表性论文（*为通讯作者；#为共同一作）

      [1]   Hu Jiang, Hu Su, Kesheng Wu, Zemin Dong, Xiangmin Li, Lijuan Nie, Yuankui Leng*, Yonghua Xiong, Multiplexed lateral flow immunoassay based on inner filter effect for mycotoxin detection in maize. Sensors and Actuators B: Chemical, 2023, 374, 132793. 

  [2]   Ling Chen#, Yuan-Kui Leng#, Shi Qiu, Bin Liu, Juan Liu, Sheng-Peng Wan, Tao Wu, Hengyi Xu, Yonghua Xiong, Jinhui Yuan, Xiangjun Xin, Danling Wang, Xing-Dao He, Qiang Wu, Ultrahigh-sensitivity label-free singlemode- tapered no core-singlemode fiber immunosensor for Listeria monocytogenes detection. Sensors and Actuators B: Chemical, 2023, 376，132930.

  [3]   Ge Xu, Xiaojing Fan, Xirui Chen, Zilong Liu, Guoxin Chen, Xiaxia Wei, Xiangmin Li, Yuankui Leng *, Yonghua Xiong and Xiaolin Huang*, Ultrasensitive Lateral Flow Immunoassay for Fumonisin B1 Detection Using Highly Luminescent Aggregation-Induced Emission Microbeads. Toxins 2023, 15, 79.

  [4]   Qian Guo，Jun Huang，Hao Fang，Xiaoyang Li，Yu Su，Yonghua Xiong， Yuankui Leng* and  Xiaolin Huang*， Gold nanoparticle-decorated covalent organic frameworks as amplified light-scattering probes for highly sensitive immunodetection of Salmonella in milk. Analyst, 2023, 148.17: 4084-4090.

[5]   冷远逵*，范思雨，胡馨予，熊勇华*,动态光散射传感器在食品安全检测中的应用进展. 食品与生物技术学报, 2023，42(7):1-10.

  [6]   冷远逵*，黄诗锦，陈樨蕊，熊勇华*, 基于双功能纳米探针的免疫层析技术在食品安全检测中的应用. 食品与发酵工业, 2023, 49(6):300-307.

  [7]   Weipeng Tong, Hao Fang, Hanpeng Xiong, Daixian Wei, Yuankui Leng*, Xinyu Hu, Xiaolin Huang, Yonghua Xiong. Eco-Friendly Fluorescent ELISA Based on Bifunctional Phage for Ultrasensitive Detection of Ochratoxin A in Corn. Foods 2021, 10(10), 2429.

  [8]   Yaofeng Zhou#，XiaolinHuang#，Xinyu Hu，Weipeng Tong，Yuankui Leng*， YonghuaXiong. Recent advances in colorimetry/fluorimetry-based dual-modal sensing technologies. Biosensors and Bioelectronics, 2021, 190: 113386. 

  [9]   Zhuolin Song, Lin Feng, Yuankui Leng*, Mingzhu Huang, Hao Fang, Weipeng Tong, Xuelan Chen,* and Yonghua Xiong，Dramatically Enhancing the Sensitivity of Immunoassay for Ochratoxin A Detection by Cascade-Amplifying Enzyme Loading. Toxins, 2021, 13, 781.

  [10]  Ling Chen#, Yuan Kui Leng#, Bin Liu, Juan Liu, Sheng-Peng Wan, Tao Wu, Jinhui Yuan, Liyang Shao, Guoqiang Gu, Yong Qing Fu, Hengyi Xu, Yonghua Xiong, Xing-Dao He, Qiang Wu, Ultrahigh-sensitivity label-free optical fiber biosensor based on a tapered singlemode- no core-singlemode coupler for Staphylococcus aureus detection. Sensors and Actuators B: Chemical, 2020，320，128283.

  [11]   Liangwen Hao#, Yuankui Leng#, Lifeng Zeng, Xirui Chen, Jing Chen,Hong Duan, Xiaolin Huang*, Yonghua Xiong*, Xiaoyuan Chen. Core–Shell-Heterostructured Magnetic–Plasmonic Nanoassemblies with Highly Retained Magnetic–Plasmonic Activities for Ultrasensitive Bioanalysis in Complex Matrix. Advanced science, 2020, 7(2): 1902433. 

  [12]   Ying Xiong#， YuankuiLeng#， Xiangmin Li，Xiaolin Huang*，Yonghua Xiong*. Emerging strategies to enhance the sensitivity of competitive ELISA for detection of chemical contaminants in food samples. TrAC Trends in Analytical Chemistry, 2020, 126: 115861. 

  [13]   Xirui Chen#, Yuankui Leng#, Liangwen Hao, Hong Duan, Jing Yuan, Wenjing Zhang, Xiaolin Huang*, and Yonghua Xiong*. Self-assembled colloidal gold superparticles to enhance the sensitivity of lateral flow immunoassays with sandwich format. Theranostics. 2020; 10(8): 3737–3748.

  [14]   Yuqian Guo， Yaofeng Zhou， Sicheng Xiong， Lifeng Zeng， Xiaolin Huang， Yuankui Leng*，YonghuaXiong*.Natural enzyme-free colorimetric immunoassay for human chorionic gonadotropin detection based on the Ag+-triggered catalytic activity of cetyltrimethylammonium bromide-coated gold nanoparticles. Sensors and Actuators B: Chemical,2020,305: 127439.

  [15]   Wenjing Zhang， Hong Duan， Rui Chen， Tongtong Ma， Lifeng Zeng， Yuankui Leng*，Yonghua Xiong*，Effect of different-sized gold nanoflowers on the detection performance of immunochromatographic assay for human chorionic gonadotropin detection. Talanta, 2019, 194: 604-610.

  [16] Tongtong Ma, Hong Duan, Wenjing Zhang, Yanna Shao, Liangwen Hao, Xirui Chen, Yuankui Leng *, Xiaolin Huang and Yonghua Xiong*. An amphiphilic-ligand-modified gold nanoflower probe for enhancing the stability of lateral flow immunoassays in dried distillers grains. RSC Adv., 2019, 9, 36670-36679. 

  [17]  Rahul Kumar#, Yuankui Leng#, Bin Liu, Jun Zhou, Liyang Shao, Jinhui Yuan, Xinyu Fan, Shengpeng Wan, Tao Wu, Juan Liu, Richard Binns, Yong Qing Fu, Wai Pang Ng, Gerald Farrell, Yuliya Semenova, Hengyi Xu, Yonghua Xiong, Xingdao He, Qiang Wu, Ultrasensitive biosensor based on magnetic microspheres enhanced microfiber interferometer. Biosensors and Bioelectronics, 2019，145，111563.

  [18] Tianying Lu, Shengnan Zhan, Yaofeng Zhou, Xirui Chen, Xiaolin Huang, Yuankui Leng *, Yonghua Xiong, and Yang Xu. Fluorescence ELISA based on CAT-regulated fluorescence quenching of CdTe QDs for sensitive detection of FB1. Analytical Methods, 2018,10, 5797-5802.

  [19]  Yanna Shao, Hong Duan, Liang Guo, Yuankui Leng*, Weihua Lai, YonghuaXiong*, Quantum dot nanobead-based multiplexed immunochromatographic assay for simultaneous detection of aflatoxin B1 and zearalenone. Analytica Chimica Acta, 2018, 1025: 163-171.

  [20]  Xirui Chen，Yi Liang，Wenjing Zhang，Yuankui Leng*，YonghuaXiong*，A colorimetric immunoassay based on glucose oxidase-induced AuNP aggregation for the detection of fumonisin B1. Talanta, 2018, 186: 29-35. 

  [21]    Yuankui Leng, Weijie Wu, Li Li, Kun Lin, Kang Sun, Xiaoyuan Chen, and Wanwan Li, Magnetic/Fluorescent Barcodes Based on Cadmium-Free Near-Infrared-Emitting Quantum Dots for Multiplexed Detection. Advanced Functional Materials, 2016, 26, 7581–7589. 

      [22]    Yuankui Leng, Kang Sun*, Xiaoyuan Chen* and Wanwan Li*, Suspension arrays based on nanoparticle-encoded microspheres for high-throughput multiplexed detection. Chemical Society Reviews, 2015, 44, 5552—5595.

      [23]   Gang Wang#, Yuankui Leng#, Heze Guo, Sheng Song, Zequan Jiang, Xiangliang Yuan, Xiebing Wang, Kang Sun,* Kun Sun and Hongjing Dou*,J. Mater. Chem. B, 2014, 2, 8310–8313.