学科方向：食品营养与功能，食品运载体构建与活性成分靶向递送, 食品组分相互作用, 食品质量与安全分析等

所属院系：食品学院

研究方向

食品营养与功能，食品运载体构建与活性成分靶向递送, 食品组分相互作用, 食品质量与安全分析等。

个人经历

张国文，二级教授，博士，博士生导师。宝钢优秀教师奖获得者，省部级人才，2020-2023年连续4年入选科睿唯安全球“高被引科学家”和爱思唯尔中国高被引学者榜单，2021-2023年连续3年入选全球前2%顶尖科学家终身科学影响力排行榜和年度科学影响力排行榜，南昌大学食品科学与资源挖掘全国重点实验室固定成员与学术带头人，国家自然科学基金评审专家，国家重点研发项目评审专家，中国工程教育专业认证专家，国家一流本科课程主持人，江西省食品安全专家委员会委员，江西省普通高校食品科学与工程类教指委委员、江西省食品科学技术学会理事，江西省预防医学会卫生检验专业委员会副主任委员、江西省高新技术企业认定评审专家，广东、湖南、福建、云南、江西等省政府科技成果奖评审专家，Foods、分析试验室、中国调味品等学术期刊编委，Food Chemistry, Journal of Agricultural and Food Chemistry,Food Hydrocolloids,  Analytical Chemistry, Food and Function, Food Research International, Journal of Hazardous Materials, , 食品科学等40多家国内外著名学术期刊审稿专家。

讲授课程

承担的本科生课程：

食品分析、现代食品检测技术、膳食营养与健康、食品分析实验、现代食品检测技术实验、食品科学技术前沿、认识实习、生产实习、毕业实习

承担的研究生课程：

高等分析化学、食品科学技术研究进展、营养与食品科学技术研究进展

学术成就

主持国家自然科学基金项目（含面上项目）、教育部高校博士点基金（博导类）项目、国家重点实验室项目、江西省重大科技项目、江西省自然科学基金项目、江西省科技支撑项目等国家级和省部级科研项目30多项。在Journal of Agricultural and Food Chemistry, Food Chemistry, Food Hydrocolloids, Food & Function, Food Research International 等国内外知名学术期刊上发表论文360多篇，其中SCI收录180多篇，入选ESI高被引论文12篇，ESI热点论文4篇，h指数50，Web of Science收录论文总被引频次8000多次；是国家一流本科课程《食品分析》主持人，获得国家级教学成果二等奖3项，江西省教学成果一等奖4项、二等奖4项，江西省自然科学三等奖2项，江西省高等学校科技成果三等奖1项和吉安市科技进步三等奖1项，主编教材5部。

近年来，指导的研究生已有20人获得研究生国家奖学金，5人获得江西省政府奖学金，16人获得江西省优秀博士或硕士学位论文，多次被评为江西省优秀硕士学位论文指导教师和南昌大学优秀研究生指导教师，获得南昌大学教学名师、“科研先进个人”、“中兴发展奖教金”、“江铃奖教金“、韦林奖教金”和 “教书育人”先进个人等荣誉和奖励。

承担课题

近年来承担的部分科研项目：

(1) 基于“α-糖苷酶-糖脂代谢-肠道菌群”探究橙皮素-铜(II)配合物降血糖作用机制(22478172)，国家基金面上项目, 2025.1.1-2028.12.31. 主持

(2)水和乳化剂介导的巴西棕榈蜡基结构化乳液稳态化构建机制研究(32460566)，国家基金项目, 2025.1.1-2028.12.31. 主持

(3) 橙皮素-铜(II)配合物对黄嘌呤氧化酶的抑制作用及其降尿酸机制研究(22078143). 国家基金面上项目, 2021.1-2024.12, 主持.

(4) 基于化学计量学的合成食品添加剂体外DNA靶向作用检测技术及其作用机制研究(31460422). 国家基金项目, 2015.1-2018.12, 主持.

(5) 具有潜在致癌性的有机氮农药与DNA的相互作用机制(21167013). 国家基金项目, 2012.1-2015.12, 主持.

(6) 几种抗心血管病黄酮化合物与蛋白质的相互作用及典型食物营养物的影响机制(31060210), 国家基金项目, 2011.1-2013.12, 主持.

(7) 基于乳清蛋白三元共价偶联物基O/W型乳液递送体系构建及其对β-胡萝卜素的保护与控释机制（20242BAB26103 ），江西省基金重点项目， 2024.6.1-2027.5.30, 主持

(8) 橙皮素-铜(II)配合物抑制α-葡萄糖苷酶活性和AGEs 形成的分子机制研究(20212ACB205010)，江西省基金重点项目 2021.1.1-2023.12.31，主持

(9) 基于巴西棕榈蜡的递送体系构建及其对姜黄素的保护与控释机制研究（SKLF-ZZB-202331），国家重点实验室项目, 2023.1.1-2024.12.31，主持

(10) 基于巴西棕榈蜡的递送体系构建及其结晶机制研究(ZBG20230418035), 江西省财政科技专项, 2023.1.1-2025.12.31, 主持

(11) 茶多酚抑制黄嘌呤氧化酶活性的分子机制及其与别嘌呤醇联合抑制效应研究(20202BAB205005), 江西省基金项目, 2020.1-2021.12, 主持.

(12) 茶多酚抑制酪氨酸酶活性的分子机制及其与曲酸的联合抑制作用研究(SKLF-ZZB-201914), 国家重点实验室项目, 2019.1-2020.12, 主持.

(13) 桦木酸对α-葡萄糖苷酶活性和糖基化终末产物形成的抑制作用及机理研究(SKLF-ZZB-201707), 国家重点实验室项目, 2017.1-2018.12, 主持.

(14) 高良姜素对α-葡萄糖苷酶活性及糖基化终末产物形成的抑制作用研究(20171BAB204029), 江西省基金项目, 2017.1-2018.12, 主持.

(15) 几种具有潜在致癌性的人工合成食品添加剂与靶分子DNA的识别机制(20123601110005). 教育部高等学校博士学科点基金项目（博导类）, 2013.1-2015.12, 主持.

(16) 食品中化学危害因子风险的形成机制及检测新技术研究(20143ACB20006). 江西省重大科技项目, 2015.1-2017.12, 主持.

(17) 山柰酚、桑色素抑制黄嘌呤氧化酶活性的分子机制及其联合抑制行为研究(20142BAB204001). 江西省基金项目, 2014,1-2015.12, 主持.

(18) 蛋白质-多糖对芹菜素的包载、释放及其抑制α-葡萄糖苷酶活性的机制研究(GJJ150187). 江西省教育厅科技项目, 2016.1-2018.12, 主持.

(19) 基于化学计量学的合成食品添加剂DNA靶向作用检测新技术研究(20141BBG70092). 江西省科技支撑项目, 2014,1-2015.12, 主持.

(20) 棕榈油在胶囊中作为营养物载体的应用，大马棕榈油技术研发（上海）有限公司（横向课题）, 2018.1-2019.12. 主持.

(21) 棕榈油在在野生菌油中的应用，大马棕榈油技术研发（上海）有限公司（横向课题）, 2019.1-2020.12. 主持.

(22) 棕榈油在抗融型冰淇淋专用油中的应用，大马棕榈油技术研发（上海）有限公司（横向课题）, 2019.1-2020.12. 主持.

论文专著

近年来发表的部分论文：

(1)Mengting Ni, Xing Hu, Deming Gong, Guowen Zhang*. Inhibitory mechanism of vitexin on α-glucosidase and its synergy with acarbose. Food Hydrocolloids, 2020,105:105782.

(2)Xiaqing Wu, Guowen Zhang*, Mingming Hu , Junhui Pan, Ang Li, Ying Zhang. Molecular characteristics of gallocatechin gallate affecting protein glycation. Food Hydrocolloids, 2020,105:105782.

(3)Hui Xue, Yonggang Tu, Meng Xu, Mingfu Liao, Wenxiang Luo, Weibo Guo, Guowen Zhang*, Yan Zhao*. Changes in phtysicochemical properties, gel structure and in vitro digestion of marinated egg white gel during braising. Food Chemistry, 2020,330:127321.

(4) Zhisheng Zhou, Xing Hu, Xinyue Hong, Jie Zheng, Xia Liu, Deming Gong, GuowenZhang*. Interaction characterization of 5−hydroxymethyl−2−furaldehyde with human serum albumin: Binding characteristics, conformational change and mechanism. Journal of Molecular Liqulids, 2020,297:111835.

(5) Rui Wang, Na Li, Xing Hu, Junhui Pan, Guowen Zhang*, Xinan Zeng, Deming Gong. Characterizing the binding oftert-butylhydroquinone and its oxidation producttert-butylquinone with calf thymus DNA in vitro. Journal of Molecular Liqulids, 2020,302:112338.

(6)Huafang Ding, Mengting Ni, Guowen Zhang*, Yijing Liao, Xing Hu, Ying Zhang, Deming Gong. The inhibition of oleanolic acid on protein non-enzymatic glycation, LWT-Food Science and Technology, 2020, 125: 109253.

(7)Sha Li, Junhui Pan, Xing Hu*, Ying Zhang, Deming Gong, Guowen Zhang*. Kaempferol inhibits the activity of pancreatic lipase and its synergistic effect with orlistat. Journal of Functional Foods, 2020, 72: 104041.

(8)Xin Song, Xing Hu, Ying Zhang, Junhui Pan, Deming Gong, Guowen Zhang*. Inhibitory mechanism of epicatechin gallate on tyrosinase: inhibitory interaction, conformational change and computational simulation. Food & Function, 2020, 11(6): 4892-4902.

(9) Na Li , Xing Hu, Junhui Pan, Ying Zhang, Deming Gong, Guowen Zhang*. Insights into the mechanism of groove binding between 4−octylphenol and calf thymus DNA. Spectrochimixa Acta, Part A, 2020, 238: 118454.

(10)Guowen Zhang, Zhisheng Zhou, Jianjian Xu, Yijing Liao, Xing Hu*. Article: Groove binding between ferulic acid and calf thymus DNA: Spectroscopic methodology combined with chemometrics and molecular docking studies. Journal of Biomolecular Structure and Dynamics, 2020,38(7):2029-2037.

(11)Hui Xue, Meng Xu, Mingfu Liao, Wenxiang Luo, Guowen Zhang, Yonggang Tu*, Yan Zhao*. Effects of tea and illicium verum braise on physicochemical characteristics, microstructure, and molecular structure of heat-induced egg white protein gel. Food Hydrocolloids, 2020, 110: 106181.

(12)Mingming Hu, Kailin Pan, Yueting Niu, Shiqing Chen, Jun Hao Yoong, Azmil Haizam Ahmad Tarmizi, Guowen Zhang*. Comparative assessment of thermal resistance of palm stearin and high oleic blended oil when subjected to frying practice in fast food restaurants. Journal of Oil Palm Research, 2020, 32(1) : 90-102.

(13) Li Zeng#, Huafang Ding#, Xing Hu, Guowen Zhang*, Deming Gong. Galangin inhibits α-glucosidase activity and formation of non-enzymatic glycation products. Food Chemistry, 2019, 271: 70-79.

(14) Rui Wang, Xing Hu, Junhui Pan, Deming Gong, Guowen Zhang*. Interaction between quinoline yellow and human serum albumin: Spectroscopic, chemometrics and molecular docking studies. Journal of the Science of Food and Agriculture, 2019, 99(1): 73-82.

(15) Xing Hu, Jiawei Du, Junhui Pan, Fengfeng Wang, Deming Gong, Guowen Zhang*. Colorimetric detection of the β-agonist ractopamine in animal feed, tissue and urine samples using gold–silver alloy nanoparticles modified with sulfanilic acid. Food Additives & Contaminants: Part A, 2019, 36(1):35-45.

(16) Rui Wang, Yingying Liu, Xing Hu, Junhui Pan, Deming Gong, Guowen Zhang*. New insights into the binding mechanism between osthole and β-lactoglobulin: Spectroscopic, chemometrics and docking studies. Food Research International, 2019, 120: 226-234.

(17) Meihui Fan#, Huafang Ding#, Guowen Zhang*, Xing Hu, Deming Gong. Relationships of dietary flavonoid structure with its tyrosinase inhibitory activity and affinity. LWT-Food Science and Technology, 2019, 107: 25-34.

(18) Huafang Ding, Xing Hu, Ximing Xu, Guowen Zhang*, Deming Gong. Inhibitory mechanism of two allosteric inhibitors, oleanolic acid and ursolic acid on α-glucosidase. International Journal of Biological Macromolecules, 2018, 107: 1844-1855.

(19) Cen Zhang, Rui Wang, Guowen Zhang*, Deming Gong. Mechanistic insights into the inhibition of quercetin on xanthine oxidase. International Journal of Biological Macromolecules, 2018, 112: 405-412.

(20) Huafang Ding, Xiaqing Wu, Junhui Pan, Xing Hu, Deming Gong, Guowen Zhang*. New insights into the inhibition mechanism of betulinic acid on α-glucosidase. Journal of Agricultural and Food Chemistry, 2018, 66, 7065-7075.

(21) Xiaqing Wu, Huafang Ding, Xing Hu*, Junhui Pan, Yijing Liao, Deming Gong, Guowen Zhang*. Exploring inhibitory mechanism of gallocatechin gallate on a-amylase and a-glucosidase relevant to postprandial hyperglycemia. Journal of Functional Foods, 2018,48:200-209.

(22) Ni Zeng, Guowen Zhang* Xing Hu, Junhui Pan, Zhisheng Zhou, Deming Gong. Inhibition mechanism of baicalein and baicalin on xanthine oxidase and their synergistic effect with allopurinol. Journal of Functional Foods, 2018,50:172-182.

(23)Jiawei Du, Xing Hu, Guowen Zhang*, Xiaqing Wu, and Deming Gong. Colorimetric detection of cadmium in water using L-cysteine-functionalized gold–silver nanoparticles. Analytical Letters, 2018, 51(18):2906-2919.

(24) Cen Zhang, Guowen Zhang*, Yijing Liao, Deming Gong. Myricetin inhibits the generation of superoxide anion by reduced form of xanthine oxidase. Food Chemistry, 2017, 221:1569-1577.

(25) Meihui Fan, Guowen Zhang*, Junhui Pan, Deming Gong. An inhibition mechanism of dihydromyricetin on tyrosinase and the joint effects of vitamins B6, D3 or E. Food & Function, 2017, 8(7): 2601-2610.

(26) Meihui Fan, Guowen Zhang*, Xing Hu, Ximing Xu, Deming Gong. Quercetin as a tyrosinase inhibitor: Inhibitory activity, conformational change and mechanism. Food Research International, 2017, 100: 226-233.

(27) Song Li , Junhui Pan, Guowen Zhang*, Jianjian Xu, Deming Gong. Characterization of the groove binding between di-(2-ethylhexyl) phthalate and calf thymus DNA. International Journal of Biological Macromolecules, 2017, 101:736-746.

(28) Kaixin Xia , Guowen Zhang*, Deming Gong. Deciphering the intercalative binding modes of benzoyl peroxide with calf thymus DNA. Luminescence: The Journal of Biological and Chemical Luminescence, 2017, 32(6):988-998.

(29) Kaixin Xia, Guowen Zhang*, Song Li, Deming Gong. Groove binding of vanillin and ethyl vanillin to calf thymus DNA. Journal of Fluorescence, 2017, 27(5):1815-1827.

(30) Yingying Liu, Guowen Zhang*, Ni Zeng, Song Hu. Interaction between 8-methoxypsoralen and trypsin: Monitoring by spectroscopic, chemometrics and molecular docking approaches. Spectrochimica Acta, Part A, 2017, 173: 188-195

(31) Suyun Lin, Li Zeng, Guowen Zhang*, Yijing Liao, Deming Gong. Synthesis, characterization and xanthine oxidase inhibition of Cu(II)–chrysin complex. Spectrochimica Acta, Part A, 2017, 178:71-78.

(32) Xi Peng, Guowen Zhang*, Yijing Liao, Deming Gong. Inhibitory kinetics and mechanism of kaempferol on α-glucosidase. Food Chemistry, 2016, 190(1): 207-215.

(33) Mo Tao, Guowen Zhang*, Junhui Pan, Chunhong Xiong. Deciphering the groove binding modes of tau-fluvalinate and flumethrin with calf thymus DNA. Spectrochimica Acta, Part A, 2016, 155(15): 28-37.

(34) Xiaoyue Zhou, Cen Zhang, Guowen Zhang*, Yijing Liao. Intercalation of daphnetin–Cu(II) complex with calf thymus DNA. RSC Advances, 2016, 6: 5408-5418.

(23) Xi Peng, Guowen Zhang*, Li Zeng. Inhibition of α-glucosidase by vitamin D3 and the effect of vitamins B1 and B2. Food & Function, 2016, 7(2): 982-991.

(35) Suyun Lin, Guowen Zhang*, Yijing Liao, Deming Gong. Inhibitory kinetics and mechanism of dietary vitamins D3 and B2 on xanthine oxidase. Food & Function, 2016, 7: 2849-2861.

(36) Li Zeng, Guowen Zhang*, Yijing Liao, Deming Gong. Inhibitory mechanism of morin on α-glucosidase and its anti-glycation properties. Food & Function, 2016, 7: 3953-3963.

(37) Li Zeng, Guowen Zhang*, Suyun Lin, Deming Gong. Inhibitory mechanism of apigenin on α-glucosidase and synergy analysis of flavonoids. Journal of Agricultural and Food Chemistry, 2016, 64 (37):6939–6949.

(38) Cen Zhang, Guowen Zhang*, Junhui Pan, Deming Gong. Galangin competitively inhibits xanthine oxidase by a ping-pong mechanism. Food Research International, 2016, 89: 152-160.

(39) Yaping Wang, Guowen Zhang*, Langhong Wang. Potential toxicity of phthalic acid esters plasticizer: Interaction of dimethyl phthalate with trypsin in vitro. Journal of Agricultural and Food Chemistry, 2015, 63(1):75-84.

(40) Yajie Wang, Guowen Zhang*, Junhui Pan, Deming Gong. Novel insights into the inhibitory mechanism of kaempferol on xanthine oxidase. Journal of Agricultural and Food Chemistry, 2015, 63(2):526-534.

(41) Yue Zhang, Junhui Pan, Guowen Zhang*, Xiaoyue Zhou. Intercalation of herbicide propyzamide into DNA using acridine orange as a fluorescence probe. Sensors & Actuators: B. Chemical, 2015, 206: 630-639.

(42)Xiaoyue Zhou, Guowen Zhang*, Junhui Pan. Groove binding interaction between daphnetin and calf thymus. International Journal of Biological Macromolecules, 2015, 74:185-194.

(43) Suyun Lin, Guowen Zhang*, Yijing Liao, Junhui Pan, Deming Gong. Dietary flavonoids as xanthine oxidase inhibitors: Structure–affinity and structure–activity relationships. Journal of Agricultural and Food Chemistry, 2015, 63(2):7784-7794.

(44) Suyun Lin, Guowen Zhang*, Junhui Pan, Deming Gong. Deciphering the inhibitory mechanism of genistein on xanthine oxidase in vitro. Journal of Photochemistry and Photobiology B: Biology, 2015, 153: 463-472.

(45) Langhong Wang, Mo Tao, Guowen Zhang*, Song Li, Deming Gong. Partial intercalative binding of food colorant erythrosine to herring sperm DNA. RSC Advances, 2015, 5(119): 98366 -98376.

(46) Yu Li, Guowen Zhang*, Junhui Pan, Yue Zhang. Determination of metolcarb binding to DNA by spectroscopic and chemometrics methods with the use of acridine orange as a probe. Sensors & Actuators: B. Chemical, 2014, 191: 464-472.

(47) Jiakai Yan, Guowen Zhang*, Junhui Pan, Yajie Wang. α-Glucosidase inhibition by luteolin: Kinetics, interaction and molecular docking. International Journal of Biological Macromolecules, 2014, 64: 213-223.

(48) Guowen Zhang*, Langhong Wang, Xiaoyue Zhou, Yu Li, Deming Gong. Binding characteristics of sodium      saccharin with calf thymus DNA in vitro. Journal of Agricultural and Food Chemistry, 2014, 62(4): 991-1000.

(49) Yajie Wang, Guowen Zhang*, Jiakai Yan, Deming Gong. Inhibitory effect of morin on tyrosinase: Insights from spectroscopic and molecular docking studies. Food Chemistry, 2014, 163: 226-233.

(50) Guowen Zhang*, Yadi Ma. Mechanistic and conformational studies on the interaction of food dye amaranth with human serum albumin by multispectroscopic methods. Food Chemistry, 2013, 136(2): 442-449.

(51)Yaping Wang, Guowen Zhang*, Langhong Wang. Interaction of prometryn to human serum albumin: Insights from spectroscopic and molecular docking studies. Pesticide Biochemistry and Physiology, 2014, 108:66–73.

(52) Xiaoyue Zhou, Guowen Zhang*, Langhong Wang. Probing the binding mode of psoralen to calf thymus DNA. International Journal of Biological Macromolecules, 2014, 67: 228-237.

(53) Guowen Zhang*, Yuting Hu, Junhui Pan. Interaction between toddalolatone and human serum albumin. Journal of Solution Chemistry, 2014, 43(4): 727-745.

(54) Xiaoyue Zhou, Guowen Zhang*, Langhong Wang. Binding of 8-methoxypsoralen to DNA in vitro: Monitoring by Spectroscopic and chemometrics approaches. Journal of Luminescence, 2014, 154: 116-123.

(55) Yu Li, Guowen Zhang*, Mo Tao. Binding properties of herbicide chlorpropham to DNA: Spectroscopic, chemometrics and modeling investigations. Journal of Photochemistry & Photobiology, B: Biology, 2014, 138: 109-117.

(56) Langhong Wang , Guowen Zhang*, Junhui Pan, Chunhong Xiong, Deming Gong. Intercalation binding of food antioxidant butylated hydroxyanisole to calf thymus DNA. Journal of Photochemistry & Photobiology, B: Biology, 2014, 157:253-261.

(58) Yue Zhang, Guowen Zhang*, Yu Li, Yuting Hu. Probing the binding of insecticide permethrin to calf thymus DNA by spectroscopic techniques merging with chemometrics method. Journal of Agricultural and Food Chemistry, 2013, 61(11):2638-2647.

(59) Guowen Zhang*, Peng Fu, Junhui Pan. Multispectroscopic studies of paeoniflorin binding to calf thymus DNA in vitro. Journal of Luminescence, 2013, 134: 303-309.

(60) Guowen Zhang*, Mingming Hu, Li He, Peng Fu, Lin Wang, Jia Zhou. Optimization of microwave-assisted enzymatic extraction of polyphenols from waste peanut shells and evaluation of its antioxidant and antibacterial activities in vitro. Food and Bioproducts Processing, 2013, 91(2):157-167.

(61) Guowen Zhang*, Yepeng Zhang, Yue Zhang, Yu Li. Spectroscopic studies of cyanazine binding to calf thymus DNA with the use of ethidium bromide as a probe. Sensors & Actuators: B. Chemical, 2013,182: 453-460.

(62) Guowen Zhang*, Yadi Ma. Spectroscopic studies on the interaction of sodium benzoate, a food preservative, with calf thymus DNA. Food Chemistry, 2013, 141(1):41-47.

(63) Miao Zhu, Xing Hu*, Ying Zhang, Junhui Pan, Guowen Zhang*. Revealing the groove binding characteristics of plant growth regulator 3-indoleacetic acid with calf thymus DNA. Journal of Molecular Liquids, 2021, 326: 115265.

(64) Xin Song, Mengting Ni, Ying Zhang, Guowen Zhang*, Junhui Pan, Deming Gong. Comparing the inhibitory abilities of epigallocatechin-3-gallate and gallocatechin gallate against tyrosinase and their combined effects with kojic acid. Food Chemistry, 2021, 349:12972.

(65) Mingming Hu, Miao Zhu, Le Xin, Guowen Zhang*, Shimin Wu, Xing Hu, Deming Gong. Change of benzo(a)pyrene during frying and its groove binding to calf thymus DNA. Food Chemistry, 2021, 350, 129276.

(66) Mengting Ni, Xin Song, Junhui Pan, Deming Gong, and Guowen Zhang*. Vitexin inhibits protein glycation through structural protection, methylglyoxal trapping, and alteration of glycation site. Journal of Agricultural and Food Chemistry, 2021, 69(8): 2462-2476.

(67) Guowen Zhang, Na Li, Ying Zhang, Junhui Pan*, Deming Gong. Binding mechanism of 4−octylphenol with human serum albumin: Spectroscopic investigations, molecular docking and dynamics simulation. Spectrochimica Acta Part A, 2021, 255: 119662.

(68) Sha Li, Xing Hu, Junhui Pan, Deming Gong, Guowen Zhang*. Mechanistic insights into the inhibition of pancreatic lipase by apigenin: Inhibitory interaction, conformational change and mokecular docking studies. Journal of Molecular Liquids, 2021, 335: 116505.

(69) Zhisheng Zhou, Miao Zhu, Guowen Zhang*, Xing Hu, Junhui Pan. Novel insights into the interaction mechanism of 5-hydroxymethyl-2-fur-aldehyde with β-casein and its effects on the structure and function of  β-casein. LWT - Food Science and Technology, 2021, 152: 112360.

(70)  Haihua Jiang, Xing Hu, Junhui Pan, Deming Gong, Guowen Zhang*. Effects of interaction between hesperetin/hesperidin and glutenin on the structure and functional properties of glutenin. LWT-Food Science and Technology, 2022, 155: 112983.

(71) Dan Zhang, Junhui Pan, Deming Gong, Guowen Zhang*. Groove binding of indole-3-butyric acid to calf thymus DNA: Spectroscopic and in silico approaches. Journal of Molecular Liquids, 2022, 347: 118323.

(72) Lei Chen, Miao Zhu, Xing Hu, Junhui Pan, Guowen Zhang*. Exploring the binding mechanism of ferulic acid and ovalbumin: Insights from spectroscopy, molecular docking and dynamics simulation. Journal of the Science of Food and Agriculture, 2022, 102: 3835-3846.

(73) Haihua Jiang, Junhui Pan, Xing Hu, Miao Zhu, Deming Gong, Guowen Zhang*. A combination of alkaline pH-shifting/acidic pH and thermal treatments improves the solubility and emulsification properties of wheat glutenin. Food Chemistry, 2022, 393: 133358.

(74) Guowen Zhang, Miao Zhu, Yijing Liao, Deming Gong, Xing Hu*. Action mechanisms of two key xanthine oxidase inhibitors in tea polyphenols and their combined effect with allopurinol. Journal of the Science of Food and Agriculture, 2022, 102: 7195-7208.

(75) Yijing Liao, Xi Mai, Xiaqing Wu*, Xing Hu, Xiaoqiao Luo and Guowen Zhang*. Exploring the inhibition of quercetin on acetylcholinesterase by multispectroscopic and in silico approaches and evaluation of its neuroprotective effects on PC12 cells. Molecules, 2022,27:7971.

(76) Kai Liu, Ni Zeng, Junhui Pan*, Deming Gong, Guowen Zhang*. Synthesis, characterization, toxicity evaluation and inhibitory effect of hesperitin-copper (Ⅱ) complex on xanthine oxidase. Journal of Molecular Liquids, 2022,368:120812.

(77) Zhaohua Huang, Baozhong Guo, Deming Gong, Guowen Zhang*. Oleogel-structured emulsions: A review of formation, physicochemical properties and applications. Food Chemistry, 2023, 404 :134553. 

(78) Xinyue Hong, Xin Song, Xiaqing Wu*, Change Yang, Deming Gong, Guowen Zhang*. Treatments of heating and ultrasound improve the inhibition of gallocatechin gallate on tyrosinase. Journal of the Science of Food and Agriculture, 2023, 103: 3896-3906.

(79) Xi Peng, Kai Liu, Xing Hu, Deming Gong, Guowen Zhang*. Hesperetin-Cu(II) complex as potential α-amylase and α-glucosidase inhibitor: Inhibition mechanism and molecular docking. Spectrochimica Acta Part A, 2023, 290: 122301.

(80) Xi Peng, Xing Hu, Kai Liu, Deming Gong, Guowen Zhang*. Exploring inhibitory effect and mechanism of hesperetin-Cu (II) complex against protein glycation. Food Chemistry, 2023, 416:135801.

(81)Hui Xue, Xiaoqiao Luo, Yonggang Tu, Yan Zhao, Guowen Zhang*.Amelioration of ovalbumin gel properties by EGCG via protein aggregation, hydrogen, and van der Waals force. Food Chemistry, 2023, 422:136248.

(82) Hui Xue, Xiaoqiao Luo, Yonggang Tu, Yan Zhao, Guowen Zhang*.Amelioration of ovalbumin gel properties by EGCG via protein aggregation, hydrogen, and van der Waals force. Food Chemistry, 2023, 422:136248.

(83) Xiaoyun Fei, Yuzhong Yan, Langhong Wang*, Zhaohua Huang, Deming Gong, Guowen Zhang* . Protocatechuic acid and gallic acid improve the emulsion and thermal stability of whey protein by covalent binding. Food Research International, 2023, 170: 113000.

(84) Miao Zhu, Xiaoyun Fei, Deming Gong, Guowen Zhang*. Effects of processing conditions and simulated digestion In vitro on the antioxidant activity, inhibition of xanthine oxidase and bioaccessibility of epicatechin gallate. Foods, 2023, 12: 2807.

(85)  Haihua Jiang, Xiaoyun Fei, Guowen Zhang*, Xing Hu, Deming Gong, Junhui Pan*. Complexing with fibrillated glutenin and orange peel pectin improves the aqueous dispersion and storage stability of hesperitin/hesperidin. Food Hydrocolloids, 2023, 145: 109138. 

(86) Wenli Shi, Guowen Zhang*, Yijing Liao, Xiaoyun Fei, Deming Gong, Xing Hu*. Anti-acetylcholinesterase mechanism of kaempferol and its synergistic effect with galanthamine hydrobromide. Food Bioscience, 2023, 56:103174

(87) Wenxin Han, Wenli Shi, Deming Gong, Guowen Zhang*. Improvement of solubility, emulsification property and stability of potato protein by pH-shifting combined with microwave treatment and interaction with pectin. Food Bioscience, 2023, 56: 103301.

(88) Wenli Shi, Wenxin Han, Yijing Liao, Jiaqi Wen, Guowen Zhang*. Inhibition mechanism of fisetin on acetylcholinesterase and its synergistic effect with galantamine. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 305: 123452.

(89) Zhaohua Huang, Baozhong Guo, Guowen Zhang*.External factors affecting the linear and nonlinear rheological behavior of oleogel-based emulsions. Food Chemistry, 2024, 439:138075. 

(90) Yuzhong Yan, Shuling Chen, Le Deng, Yuxuan Duan, Zhaohua Huang, Deming Gong, Guowen Zhang*. Construction and characterization of egg white protein-gallic acid-xanthan gum-based emulsion and oleogel. Food Hydrocolloids, 2024, 150: 109720.

(91) Jianmei Wu, Xinyue Hong, Xing Hu*, Deming Gong, Guowen Zhang*. Glycosylation and binding of α-dicarbonyl compounds and human serum albumin based on spectral analysis and molecular simulation. Journal of Molecular Structure, 2024,1304:137469.

(92) Xi Peng, Kai Liu, Xing Hu, Deming Gong, Guowen Zhang*. Hesperitin-Copper (II) complex regulates the NLRP3 pathway and attenuates hyperuricemia and renal inflammation. Foods, 2024, 13: 591.

(93)Yuzhong Yan, Xiaoyun Fei, Zhaohua Huang, Hongtao Chen, Deming Gong, Guowen Zhang*. Improvement of antioxidant, emulsification properties and thermal stability of egg white protein by covalent binding to gallic acid/tannic acid and xanthan gum. Food Bioscience, 2024,58:103789. 

(94) Yushi Wei, Le Deng, Shuling Chen, Xing Hu, Guowen Zhang*. Isoliquiritigenin retards starch digestion by increasing resistant starch content and inhibiting the activities of α-amylase and α-glucosidase. Food Bioscience, 2024, 59: 104227.

(95) Lijun Wei, Weimin Gan, Mengdie Cai, Hongping Cai, Guowen Zhang*, Xianglei Cheng*. Development of a novel HPLC-CDCL method utilizing nitrogendoped carbon dots for sensitive and selective detection of dithiocarbamate pesticides in tea. Food Chemistry, 2024, 458: 140237.

(96) Jiaqi Wen, Shuling Chen, Le Deng , Xinru Chen, Xiaoyu Jiang, Xing Hu, Deming Gong, Guowen Zhang*. Inhibitiory mechanism of phloretin on xanthine oxidase and its synergistic effect with allopurinol and febuxostat. Food Bioscience, 2024, 61: 104720.

(97) Yushi Wei, Jianmei Wu, Xi Peng, Xing Hu, Deming Gong, Guowen Zhang*. Protein glycosylation inhibitory effects and mechanisms of phloretin and phlorizin. Food Bioscience, 2024, 61: 104971.