[1] 200609-201007 云南大学 本科

[2] 201009-201507 武汉大学 博士

[1] 202501- 南昌大学

[2] 201811-202501 NYU Grossman School of Medicine NYU Grossman School of Medicine

[3] 201509-201811 MD Anderson Cancer Center MD Anderson Cancer Center

纽约大学治疗联盟基金

 第一作者或通讯作者文章(含并列；中科院1区3篇，中科院2区2篇；总影响因子: 64.9，* 第一作者, # 通讯作者):

1.     Zhang, Z.Y.*#, Ding,Y., Ezhilarasan,R., Lhakhang, T., Wang, Q., Yang, J., Modrek, A.S., Zhang, H., Tsirigos, A., Futreal, A., Draetta, G.F., Verhaak, R.G.W., Sulman, E.P. #(2022). Lineage-coupled Clonal Capture Identifies Clonal Evolution Mechanisms and Vulnerabilities of BRAFV600E Inhibition Resistance in Melanoma. Cell Discovery. 8, 102 (2022). doi: 10.1038/s41421-022-00462-7 (第一作者兼共同通讯作者, IF: 33.5，top期刊，中科院1区，被选为Featured article。文章开发了一项全序列可定制的基于CRISPR的DNA条形码技术可用于单细胞谱系追踪和捕获从而研究肿瘤治疗的克隆进化及耐药，并利用该技术鉴定了BRAF突变黑色素瘤靶向治疗耐药的新机制和潜在的治疗方案。)

2.     Zhang, Q.*, Z. Y. Zhang*#, H. Du, S. Z. Li, R. Tu, Y. F. Jia, Z. Zheng, X. M. Song, R. L. Du and X. D. Zhang# (2019). DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer. Cell Death Differ 26 (11), 2300-2313. doi: 10.1038/s41418-019-0303-z. (并列第一作者兼共同通讯作者， IF: 12. 4，top期刊，中科院1区。NRF2是重要的细胞抗氧化因子，它的蛋白水平受到其泛素连接酶KEAP1的严密调控，文章鉴定了第一个NRF2的去泛素化酶DUB3并发现它通过稳定NRF2参与结直肠癌化疗耐药。)

3.     Zhang, Z.Y.*, Xiao, X.P*, Su, T, Wu, J.Y, et al. (2017). Synthesis, structure-activity relationships and preliminary mechanism of action of novel water-soluble 4-quinolone-3-carboxamides as antiproliferative agents, European Journal of Medicinal Chemistry 140, 239-251. (第一作者, IF: 6.7，top期刊，中科院1区。文章研究了一系列喹诺酮衍生化合物的抗肿瘤活性，并发现其中活性最强的化合物通过提升细胞活性氧水平来诱导p53和bax不依赖的细胞凋亡。)

4.     Li, S.Z.*, Zhang, Z.Y.*, et al. (2022). NLK is required for Ras/ERK/SRF/ELK signaling to tune skeletal muscle development by phosphorylating SRF and antagonizing the SRF/MKL pathway. Cell Death Discov 8(1):4. doi 10.1038/s41420-021-00774-9. (并列第一作者，IF: 7.0，中科院2区。文章发现NLK激酶通过对SRF的磷酸化调控SRF/ELK和SRF/MKL信号通路稳态并调控肌细胞分化。)

5.     Zhang, Z.Y.*, Li, S.Z., Zhang, H.H., Wu, Q.R., Gong, J., Liang, T., Gao, L., Xing, N.N., Liu, W.B., Du, R.L., et al. (2015). Stabilization of ATF5 by TAK1-Nemo-Like Kinase Critically Regulates the Interleukin-1beta-Stimulated C/EBP Signaling Pathway. Mol Cell Biol 35, 778-788. doi:10.1128/MCB.01228-14 (2015). (第一作者, IF: 5.3，top期刊，中科院2区。文章发现TAK1-NLK激酶信号轴通过调控ATF5的蛋白酶体降解调控C/EBP信号通路。)

其他期刊或会议文章:

1.     Yang, J., Wang, Q., Zhang, Z. Y., Long, L., Ezhilarasan, R., Karp, J. M., Tsirigos, A., Snuderl, M., Wiestler, B., Wick, W., Miao, Y., Huse, J. T., Sulman, E. P., DNA methylation-based epigenetic signatures predict somatic genomic alterations in gliomas. Nat Commun 13, 4410, doi:10.1038/s41467-022-31827-x (2022).

2.     Zhang, H.H.*, Li, S.Z.*, Zhang, Z.Y., Hu, X.M., Hou, P.N., Gao, L., Du, R.L., and Zhang, X.D. (2014). Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage. Cell Death Differ 21, 1656-1663.

3.     JM Karp, AS Modrek, R Ezhilarasan, ZY Zhang, Y Ding, M Graciani, Erik Sulman et al. (2024). Deconvolution of the tumor-educated platelet transcriptome reveals activated platelet and inflammatory cell transcript signatures. JCI insight 9 (19), e178719.

4.     Dezhi Li, Ke Geng, Yuan Hao, Jiajia Gu, Saurav Kumar, Annabel T Olson, Christina C Kuismi, Hye Mi Kim, Yuanwang Pan, Fiona Sherman, Asia M Williams, Yiting Li, Fei Li, Ting Chen, Cassandra Thakurdin, Michela Ranieri, Mary Meynardie, Daniel S Levin, Janaye Stephens, Alison Chafitz, Joy Chen, Mia S Donald-Paladino, Jaylen M Powell, Ze-Yan Zhang, Wei Chen, Magdalena Ploszaj, Han Han, Shengqing Gu, Tinghu Zhang, Baoli Hu, Benjamin A Nacev, Medard Ernest Kaiza, Alice H Berger, Xuerui Wang, Jing Li, Xuejiao Sun, Yang Liu, Xiaoyang Zhang, Tullia C Bruno, Nathanael S Gray, Behnam Nabet, Kwok-Kin Wong, Hua Zhang. (2025). Targeted degradation of oncogenic KRAS G12V triggers antitumor immunity in lung cancer models. J Clin Invest. 135(2): e174249.

5.     Modrek, A.S., Eskilsson, E., Ezhilarasan, R., Wang, Q., Goodman, L.D., Ding, Y., Zhang, Z.Y., Bhat, K.P.P., Le, T.T.T., Barthel, F.P. and Tang, M., PDPN marks a subset of aggressive and radiation resistant glioblastoma cells. Frontiers in Oncology, p.3965.

6.     Huang, Z., Li, S., Song, W., Li, X., Li, Q., Zhang, Z., Han, Y., Zhang, X., Miao, S., Du, R., et al. (2013). Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/beta-catenin pathway by down-regulating Dickkopf-1 (DKK1). PLoS One 8, e70077.

7.     Huang, Z.B., Zhang, Z.Y., Zhang, X.D., Miao, S.Y., Wang, L.F., and Du, R.L. (2011). [Establishment of a targeting protein for Xenopus kinesin-like protein 2 C' terminal SBP-3 x Flag tagged HCT116 colorectal cancer cell model]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao Acta Academiae Medicinae Sinicae 33, 624-628.

8.     Li, S.Z., Zhang, H.H., Zhang, J.N., Zhang, Z.Y., Zhang, X.F., Zhang, X.D., and Du, R.L. (2013). ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochem Biophys Res Commun 437, 325-330.

9.     Zhang, Ze-yan; Ezhilarasan, Ravesanker; Ding, Yingwen; Wang, Qianghu; Yang, Jie; Long, Lihong; Verhaak, Roel; Sulman, Erik, Dres-04. Development Of A CRISPR-Cas9d10a Targetable, High-complexity, Single-cell Barcoding Approach for Isolation of Treatment Resistant Subclones from Heterogenous Malignant Gliomas, Neuro-Oncology, 19(suppl_6): vi64-vi64, 2017.

10.  Ze-yan Zhang, Ravesanker Ezhilarasan, Yingwen Ding, Qianghu Wang, Jie Yang, Lihong Long, Roel G. Verhaak, Erik P. Sulman. Development of a CRISPR-Cas9D10A targetable, high-complexity, single-cell barcoding approach for capture of treatment resistant subclones from heterogeneous cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4698.

11.  Ze-yan Zhang, Yingwen Ding, Ravesanker Ezhilarasan, Jie Yang, Lihong Long, Lawrence Bronk, Qianghu Wang, Erik P. Sulman. High-throughput evaluation of treatment response in patient-derived glioma stem cell models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl): Abstract nr 1917.

12.  Alessandra Audia; Arvid Das; Farah Mukheef; Ze-yan Zhang; Erik Sulman; Krishna Bhat, CBIO-08. Directed Neuronal Differentiation in GBM by Suppression of TAZ, Neuro-Oncology. 19(suppl_6): vi34, 2017.

13.  L Bronk, R Ezhilarasan, Y Ding, Z Zhang, E Sulman. RDNA-02. Tumor Treating Fields Differentially Alter Homologous Recombination in Patient Derived Glioma Cells Versus Established Lines, Neuro-Oncology 20 (suppl_6), vi222-vi222.

14.  Veerakumar Balasubramaniyan, Soon Park, Yuji Piao, Emmanuel Martínez, Jianwen Dong, Sandeep Mittal, Sabbir Khan, Ze-yan Zhang, Erik Sulman, John DeGroot. DDIS-32. MEK Inhibitors Induces Neuronal Differentiation in EGFR Amplified Glioma Stem Like Cells, Neuro-Oncology. 2019 Nov; 21(Suppl 6): vi70.