国家自然科学基金-优秀青年项目

国家自然科学基金-重大研究计划培育项目

广东省自然科学基金-杰出青年项目

深圳市科创局-优秀青年基础研究项目

深圳市科创局-高校稳定支持面上项目

发表论文  (*,第一作者; ^#, 通讯作者)：

2025

25. Liang W*, Huang S, Chen X, Jiang K, Gong X, Guo H^#, Li L^#. The small-molecule pifithrin-α deactivates ETR1 to repress shade avoidance in Arabidopsis. Science Advances. 2025 Aug 15;11(33):eadw9241.

24. Ma X*, Wang W*, Zhang J*, Jiang Z*, Xu C*, Zhu W, Shi B, Yang W, Su H, Wang X, Chen D, Wang Y, Wang J, Wang J, Liu X, Wang X, Huang X, Xie W, Cai Y, Xu K, Xin P, Liu L, Lü P, Wang Y, Chu J, Gong X^#, Chu C^#, Hu B^#. NRT1.1B acts as an abscisic acid receptor in integrating compound environmental cues for plants. Cell. 2025 Aug 7:S0092-8674(25)00816-5.

23. Wu X*, Gong X^#, Xie T^#. Mechanisms of aureobasidin A inhibition and drug resistance in a fungal IPC synthase complex. Nature Communications. 2025 May 30;16(1):5010.

22. Cahoon EB^#, Kim P, Xie T, Solis AG, Han G, Gong X, Dunn TM^#. Sphingolipid homeostasis--how do cells know when enough is enough? Implications for plant pathogen responses. Plant Physiology. 2025 Jan, kiae460.

2024

21. Zhang Z*, Fang Q*, Xie T^#, Gong X^#. Mechanism of ceramide synthase inhibition by fumonisin B1. Structure. 2024 Sep 5; 32, 1–10.

20. Xie T*, Dong F*, Han G*, Wu X*, Liu P, Zhang Z, Zhong J, Niranjanakumari S, Gable K, Gupta SD, Liu W, Harrison PJ, Campopiano DJ, Dunn TM^#, Gong X^#. Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide. Cell Reports. 2024 Feb 27;43(2),113717.

2023

19. Xie T*, Fang Q*, Zhang Z, Wang Y, Dong F, Gong X^#. Structure and mechanism of a eukaryotic ceramide synthase complex. The EMBO Journal. 2023 Dec 11;42(24):e114889.

18. Xie T*, Liu P*, Wu X, Yue J, Dong F, Zhang Z, Mahawar U, Farooq F, Vohra H, Fang Q, Liu W, Wattenberg BW^#, Gong X^#. Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Nature Communications. 2023 Jun 13;14(1):3475.

17. Liu P*, Xie T*, Wu X, Han G,  Gupta SD, Zhang Z, Yue J, Dong F, Gable K, Niranjanakumari S, Li W, Wang L, Liu W, Yao R, Cahoon EB, Dunn TM, Gong X^#.  Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex. Science Advances. 2023 Mar 29;9(13):eadg0728.

2022

16. Xie T*, Zhang Z*, Yue J*, Fang Q,  Gong X^#. Cryo-EM structures of the human surfactant lipid transporter ABCA3. Science Advances. 2022 Apr 8;8(14):eabn3727.

2021

15. Li W*, Wang L*, Wierbowski BM*, Lu M, Dong F, Liu W, Li S, Wang P, Salic A^#, Gong X^#. Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Nature Communications. 2021 Nov 29;12(1):6966.

14. Mak HY*, Ouyang Q*, Tumanov S*, Xu J, Rong P, Dong F, Lam SM, Wang X, Lukmantara I, Du X, Gao M, Brown AJ, Gong X, Shui G, Stocker R, Huang X, Chen S, Yang H^#. AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway. Nature Communications. 2021 Nov 25;12(1):6877.

13. Xie T*, Zhang Z*, Fang Q, Du B, Gong X^#. Structural basis of substrate recognition and translocation by human ABCA4.  Nature Communications. 2021 Jun 22;12(1):3853.

12. Li S*, Xie T*, Liu P*, Wang L, Gong X^#. Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex. Nature Structural & Molecular Biology. 2021 Mar;28(3):249-257.

11. Yan R*, Cao P*, Song W*, Qian H, Du X, Coates HW, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown AJ, Zhou Q, Yan C^#, Yan N^#. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. 2021 Mar 15;371(6533).

2020

10. Thomas C^#, Aller SG, Beis K, Carpenter EP, Chang G, Chen L, Dassa E, Dean M, Van Hoa FD, Ekiert D, Ford R, Gaudet R, Gong X, Holland IB, Huang Y, Kahne DK, Kato H, Koronakis V, Koth CM, Lee Y, Lewinson O, Lill R, Martinoia E, Murakami S, Pinkett HW, Poolman B, Rosenbaum D, Sarkadi B, Schmitt L, Schneider E, Shi Y, Shyng S, Slotboom DJ, Tajkhorshid E, Tieleman DP, Ueda K, Váradi A, Wen P, Yan N, Zhang P, Zheng H, Zimmer J, Tampé R^#. Structural and functional diversity calls for a new classification of ABC transporters. FEBS Letters. 2020 Dec;594(23):3767-3775.

9. Ma L*, Guan Z, Wang Q, Yan X, Wang J, Wang J, Cao J, Zhang D, Gong X^#, Yin P^#. Structural insights into the photoactivation of Arabidopsis CRY2. Nature Plants. 2020 Nov 16;6(12):1432-1438.

2019

8. Qian H*, Cao P*, Hu M, Gao S, Yan N^#, Gong X^#. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nature Communications. 2019 May 24;10(1):2320.

7. Gong X^#, Qian H. Purification and Characterization of Human Niemann–Pick C1 Protein.  Methods in Molecular Biology. 2019; 1949:257-267.

Prior to 2019：  

6. Gong X*, Qian H*, Cao P*, Zhao X, Zhou Q, Lei J, Yan N^#. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018 Aug 10;361(6402).

5. Qian H*, Zhao X, Cao P, Lei J, Yan N^#, Gong X*^, #. Structure of the human lipid exporter ABCA1. Cell. 2017 Jun 15;169(7):1228–1239.

4. Gong X*, Qian H*, Shao W*, Li J, Wu J, Liu J, Li W, Wang H, Espenshade PJ^#, Yan N^#. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Research. 2016 Nov;26(11):1197-1211.

3. Gong X*, Qian H*, Zhou X*, Wu J*, Wan T*, Cao P, Huang W, Zhao X, Wang X, Wang P, Shi Y, Gao GF, Zhou Q^#, Yan N^#. Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. Cell. 2016 Jun 2;165(6):1467-78.

2. Ren R*, Zhou X*, He Yuan, Ke M, Wu J, Liu X, Yan C, Wu Y, Gong X, Lei X, Yan SF, Radhakrishnan A, Yan N^#. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels. Science. 2015 Jun 10;349(6244).

1. Gong X*, Li J*, Shao W*, Wu J, Qian H, Ren R, Espenshade PJ^#, Yan N^#. Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Research. 2015 Apr;25(4):401-11.