个人信息姓名：肖健
国籍：中国
性别：男
毕业院校：武汉大学
职称：副研究员
学位：博士
职称类别：校聘正高
岗位类别：研究员
岗位级别：无
电子邮件：xiaojian5278@55278
所在单位：生物医学创新研究院
办公地址：医学科技创新中心307室
个人信息研究兴趣与领域：课题组主要围绕胆固醇代谢和代谢性疾病开展研究。胆固醇是生物体内必需脂类分子，它与心血管、神经退行性等诸多疾病息息相关，胆固醇代谢相关蛋白长期是许多人类疾病重要药物靶点。课题组目前以第一作者或者共同第一作者身份在国际知名期刊发表论文6篇，包括：Nature Communications, Protein & Cell等学术期刊。主要学术成绩有：1）发现溶酶体-过氧化物酶体-内质网胆固醇运输新途径，提出膜性细胞器作为转运体的新概念，为过氧化物酶体疾病治疗提供新思路。；2）打破“PCSK家族均不需要借助其他蛋白就能自催化成熟”的传统认知，鉴定了首个PCSK家族促成熟蛋白POST1/C12orf49,揭示其通过调控S1P成熟影响SREBP2介导的胆固醇合成通路；3）揭示了小肠NPC1L1介导胆固醇吸收的完整循环。
[1] 201409-202012 武汉大学 博士研究生
[2] 201009-201407 武汉大学 大学本科
[1] 2024.02- 南昌大学 基础医学院
[2] 202002-202312 武汉大学 武汉大学
(1) Jian Xiao#, Le-Wei Dong#, Shuai Liu, Fan-Hua Meng, Chang Xie, Xiao-Yi Lu, Weiping J. Zhang, Jie Luo, Bao-Liang Song*. Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling. Nature Communications 2023.
(2) Jian Xiao, Yanni Xiong, Liu-Ting Yang, Ju-Qiong Wang, Zi-Mu Zhou, Le-Wei Dong, Xiong-Jie Shi, Xiaolu Zhao, Jie Luo*, Bao-Liang Song*. POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation. Protein & Cell 2021.
(3) Jian Xiao#, Jie Luo#, Ao Hu, Ting Xiao, Mei-Xin Li, Ze-Kai Kong, Lu-Yi Jiang, Zi-Mu Zhou, Ya-Cheng Liao, Chang Xie, Bei-Bei Chu, Hong-Hua Miao, Bo-Liang Li, Xiong-Jie Shi, Bao-Liang Song*. Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins. Science China-Life Sciences, 2019. (Cover story, 年度优秀论文)
(4) Le-Wei Dong#, Jian Xiao#, Ya-Cheng Liao, Bei-Bei Chu, Gang Deng, Xiao-Lu Zhao, Bao-Liang Song, Jie Luo*. Lysosomal cholesterol accumulation is commonly found in most peroxisomal disorders and reversed by 2-hydroxypropyl-β-cyclodextrin. Science China-Life Sciences, 2023.
(5) Fan-Hua Meng#, Shuai Liu#, Jian Xiao#, Yu-Xia Zhou, Le-Wei Dong, Yun-Feng Li, Yan-Qing Zhang, Wei-Hui Li, Ju-Qiong Wang, Yan Wang, Bao-Liang Song, Yi-Tong Ma, Zhen-Yan Fu*, Jie Luo*. New Loss-of-Function mutations in PCSK9 reduce plasma LDL cholesterol. Arteriosclerosis, Thrombosis, and Vascular Biology, 2023.
(6) Jian Xiao#, Bao-Liang Song, Jie Luo*. Peroxisomes in intracellular cholesterol transport: from basic physiology to brain pathology. Exploration of Neuroprotective Therapy, 2021. (Review)
(7) Sparse deconvolution improves the resolution of live-cell super-resolution fluorescence microscopy. Nature Biotechnology, 2022. 共同作者
(8) Measurement of cholesterol transfer from lysosome to peroxisome using an in vitro reconstitution assay. Methods in Molecular Biology, 2017. 共同作者
(9) Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome. Cell Research, 2016. 共同作者
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