姓名:谢俊华
国籍:中国
联系电话:15970687145
性别:男
毕业院校:比利时根特大学
学位:博士
电子邮件:junhuax@ncu.edu.cn
所在单位:食品科学与资源挖掘全国重点实验室
职工类别:教学科研型
职称:副研究员
学科:其他
办公地址:物理楼137
职称等级:副高级
姓名拼音:Junhua Xie
所在系:食品科学与资源挖掘全国重点实验室
南昌大学食品科学与资源挖掘全国重点实验室特聘研究员,硕士生导师。比利时根特大学生物化学、生物技术与兽医学双学位博士,曾任弗拉芒生命科学研究院-根特大学炎症研究中心助理研究员。入选江西省2023年赣鄱俊才-海外急需紧缺人才和2024年赣鄱英才创新领军人才,目前主持江西省自然科学基金青年和面上项目共2项。主要从事细菌外膜囊泡与宿主健康研究,在解析细菌外膜囊泡活性分子及其免疫调控机制方面取得了一系列重要研究成果,目前以第一/通讯作者(含共同)在Journal of Extracellular Vesicles、EMBO Journal、Gut Microbes、Trends in Biotechnology等国际顶级期刊发表SCI学术论文20篇(4篇入选ESI高被引论文)。担任iMeta、Extracellular Vesicles and Circulating Nucleic Acids和《现代食品科技》青年编委、Frontiers in Environmental Microbiology编委,Advanced Science, Journal Advanced Research, Journal of Neuroinflammation,Pharmacological Research和Reaearch等期刊评审专家。
研究方向
1. 食品营养组分与肠道菌互作;
2. 微生态制剂与神经健康;
3. 益生菌外膜囊泡功能解析;
4. 新型后生元应用开发。
[1] 201810-202212 比利时根特大学 博士研究生
[2] 201409-201606 南昌大学 硕士研究生
[3] 201009-201406 中国农业大学 大学本科
[1] 202309-* 南昌大学 南昌大学
[2] 202212-202309 比利时弗拉芒生命科学研究院-根特大学炎症研究中心 比利时弗拉芒生命科学研究院-根特大学炎症研究中心
江西省自然科学基金面上项目,20252BAC240711,主持
江西省赣鄱英才创新领军人才青年类项目,gpyc20240047,主持
江西省自然科学基金青年项目,20242BAB21031,主持
赣鄱俊才-海外急需紧缺人才
1. Chen X, Li Q, Zhang W, Xu Y, Nie X, Wang X, Chen C, Xie J*, Nie S*. Akkermansia muciniphila-derived extracellular vesicles alleviate colitis-related cognitive impairment via tryptophan metabolic reprogramming of the gut-brain axis. Gut Microbes. 2026 Jan 18(1): 2611546. (IF=11.0; Q1)
2. Nie X, Li Q, Fatima H, Wang Y, Meng F, Xie J*, Nie S*. Advances in mammalian, plant, and bacterial-derived extracellular vesicles for cancer therapy. Chemical Engineering Journal. 2025 Nov 1;532: 168637 (IF=13.2; Q1)
3. Li Q, Chen X, Wang Y, Meng F, Xie J*, Nie S*. Engineered bacterial extracellular vesicles: developments, challenges, and opportunities. Engineering. 2025 Jul 22 (IF=11.6; Q1)
4. Nie X, Li Q, He Y, Xu Y, Qiao S, Wang X, Meng F, Xie J*, Nie S*. Engineered bacterial extracellular vesicles for gastrointestinal diseases. Journal of Controlled Release. 2025 Sep 10;385: 113972 (IF=11.5; Q1)
5. Xie J#, Burgelman M#, Dujardin P, et al. Gut microbiota modulates CNS barrier function in murine model for multiple sclerosis. Fluids and Barriers of the CNS. 2025 Nov 22, 114 (IF= 6.2; Q1)
6. Xie J#, Van Hoecke L#, Van Wonterghem E, Van Imschoot G, Andries V, Lars Vereecke L, Vandenbroucke R*. The gut-brain axis in Alzheimer's disease is shaped by commensal gut microbiota derived extracellular vesicles. Gut Microbes. 2025 Dec;17(1):2501193 (IF=11.0; Q1)
7. Nie X, Li Q, Ji H, Zhang S, Wang Y, Xie J*, Nie S*. Bifidobacterium longum-derived extracellular vesicles ameliorate ulcerative colitis by modulating T cell responses in gut microbiota-(in)dependent manners. npj Biofilms and Microbiomes. 2025 Feb; 11(1): 27. (IF=7.8; Q1; 高被引文章)
8. Chen X, Li Q, Xie J*, Nie S*. Immunomodulatory effects of probiotic-derived extracellular vesicles: opportunities and challenges. Journal of Agricultural and Food Chemistry. 2024 Sep 4;72(35):19259-19273. (IF=6.1; Q1)
9. Nie X, Li Q, Chen C, Onyango S, Xie J*, Nie S*. Bacterial extracellular vesicles: Vital contributors to physiology from bacteria to host. Microbiological Research. 2024 Apr 25:284:127733 (IF=6.7; Q1)
10. Xie J, Van Hoecke L, Van Wonterghem E, et al. The gut-brain axis in Alzheimer’s disease is shaped by commensal gut microbiota derived extracellular vesicles. Gut Microbes. 2025 May; 17(1). (IF=12.2; Q1)
11. Xie J, Li Q, Nie S, et al. Bacterial extracellular vesicles: An emerging postbiotic. Trends in Food Science & Technology. 2023 Dec;31(12):1206-1224 (IF=15.3; Q1)
12. Xie J, Cools L, Van Imschoot G, et al. Helicobactor pylori-derived outer membrane vesicles contribute to Alzheimer’s disease pathogenesis via C3-C3aR signaling. Journal of Extracellular Vesicles. 2023 Feb;12(2):e12306 (IF=16.0; Q1; 高被引文章)
13. Xie J, Haesebrouck F, Van Hoecke L, et al. Bacterial extracellular vesicles: An emerging avenue to tackle diseases. Trends in Microbiology. 2023 Jun (IF=15.9; Q1; 高被引文章)
14. Xie J, Bruggeman A, De Nolf C, et al. Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology. The EMBO Journal. 2023 Jul: e111515 (IF=11.4; Q1)
15. Xie J, Li Q, Haesebrouck F, et al. The tremendous biomedical potential of bacterial extracellular vesicles. Trends in Biotechnology. 2022 Oct;40(10):1173-1194. (IF=17.3; Q1; 高被引文章)
16. Xie J, Van Hoecke L, Vandenbroucke RE*. The impact of systemic inflammation on Alzheimer's disease pathology. Frontiers in Immunology. 2022 Jan 6;12:796867. (IF=7.3; Q1; 高被引文章)
17. Xie J, Gorlé N, Vandendriessche C, Van Imschoot G, Van Wonterghem E, Van Cauwenberghe C, Parthoens E, Van Hamme E, Lippens S, Van Hoecke L, Vandenbroucke RE*. Low-grade peripheral inflammation affects brain pathology in the AppNL-G-F mouse model of Alzheimer's disease. Acta Neuropathologica Communications. 2021 Oct 7;9(1):163. (IF= 7.1; Q1)
18. Xie J, Fan S, Nie S*, Yu Q, Xiong T, Gong D, Xie M. Lactobacillus plantarum NCU116 attenuates cyclophosphamide-induced intestinal mucosal injury, metabolism and intestinal microbiota disorders in mice. Food & Function. 2016 Mar;7(3):1584-1592. (IF= 6.1; Q1)
19. Xie J, Nie S*, Yu Q, Yin J, Xiong T, Gong D, Xie M. Lactobacillus plantarum NCU116 attenuates cyclophosphamide-induced immunosuppression and regulates Th17/Treg cell immune responses in mice. Journal of Agricultural and Food Chemistry. 2016 Feb 17;64(6):1291-1297. (IBA1=6.1; Q1)
20. Xie J, Yu Q, Nie S*, Fan S, Xiong T, Xie M. Effects of Lactobacillus plantarum NCU116 on intestine mucosal immunity in immunosuppressed mice. Journal of Agricultural and Food Chemistry. 2015 Dec 30;63(51):10914-10920. (IF= 6.1; Q1)