学科方向：精准食品营养在调节人体健康中的应用研究

所属院系：食品学院

研究方向

（1）食品功能因子的稳态化及其精准递送；

（2）食品蛋白质组学；

（3）生物仿生载体的构建及其在疾病治疗中的应用；

（4）功能化纳米颗粒的构建及其在癌症精准治疗中的应用。

个人经历

1990年4月生；南昌大学食品科学与资源挖掘全国重点实验室教授，南昌大学食品学院教授，博士生导师。之前于美国斯坦福大学进行博士后研究学习。在食品科学、分析科学、生命科学、材料化学等领域开展了前沿性的基础研究，并注重将科学研究与改善人体健康密切关联。研究方向主要集中在食品功能因子的稳态化及其精准递送；食品蛋白质组学；生物仿生载体的构建及其在疾病治疗中的应用；功能化纳米颗粒的构建及其在癌症精准治疗中的应用。主持多项国家级和省级基金。在国际高水平期刊发表多篇高水平学术论文，包括Nature Methods、Nature Communications、PNAS、Advanced Materials、Advanced Functional Materials、ACS Nano、Advanced Healthcare Materials和Food Chemistry等。截止2023，所发表论文总累积引用4078次。申请和授权专利9项。研究开发了核酸提取纳米产品，已在市场上有了较好的销售。担任国际著名SCI学术期刊审稿人，包括Analytical Chemistry、ACS Applied Materials & Interface、Theranostics、Carbon、Analytica Chimica Acta等。

学术成就

主持国家自然科学基金和江西省自然科学基金；在国际高水平期刊发表多篇高水平学术论文，包括Nature Methods、Nature Communications、PNAS、Advanced Materials、Advanced Functional Materials、ACS Nano、Advanced Healthcare Materials和Food Chemistry等。截止2023，所发表论文总累积引用4078次。申请和授权专利9项。研究开发了核酸提取纳米产品，已在市场上有了较好的销售。担任国际著名SCI学术期刊审稿人，包括Analytical Chemistry、ACS Applied Materials & Interface、Theranostics、Carbon、Analytica Chimica Acta等。

论文专著

1. Ji, H., Wan, Y., Li, S., Zhou, D., Gu, F., Sun, J., Yan, X., Le, Y., Chen, T.*, Nie, S.*, Wan, H*. Remolding probiotics for effective treatment of type 2 diabetes via oral administration. Biomaterials, 2024, 315, 122970. DOI: 10.1016/j.biomaterials.2024.122970.

2. Xie, P.,#, Liu, J.,#, Liao, Z., Zhou, Q., Sun, J., Liu, Z.,*, Xiong, H.,*, Wan, H*. Profiling the differential phosphoproteome between breast milk and infant formula through a titanium (IV)-immobilized magnetic nanoplatform. Food Chemistry, 2025, 464, 141541. DOI: 10.1016/j.foodchem.2024.141541.

3. Wan, X., Zhang, Y., Wan, Y.*, Xiong, M., Xie, A., Liang, Y.*, Wan, H*. A Multifunctional Biomimetic Nanoplatform for Dual Tumor Targeting-Assisted Multimodal Therapy of Colon Cancer. ACS Nano, 2024, 18(39), 26666-26689. DOI: 10.1021/acsnano.4c05773.

4. Xiong, M.#, Zhang, Y.#, Zhang, H.#, Shao, Q.#, Hu, Q.#, Ma, J., Wan, Y.,  Guo, L.*, Wan, X., Sun, H., Yuan, Z.*, Wan, H*. A Tumor Environment-Activated PhotosensitizedBiomimetic Nanoplatform for Precise PhotodynamicImmunotherapy of Colon Cancer. Advanced Science, 2024,11(28), 2402465. DOI: 10.1002/advs.202402465.

5. Wang, X.#, Jiao, M.#, Tian, F., Lu, X., Xiong, H., Liu, F., Wan, Y.*, Zhang, X.*, Wan, H*. A Biomimetic Nanoplatform with Improved Inflammatory Targeting Behavior for ROS Scavenging-Based Treatment of Ulcerative Colitis (Cover paper). Advanced Healthcare Materials, 2023, 12(29), 2301450. DOI: 10.1002/adhm.202301450.

6. Xie, A.#, Ji, H.#, Liu, Z.#, Wan, Y.*, Zhang, X., Xiong, H., Nie, S.*, Wan, H*. Modified Prebiotic-Based “Shield” Armed Probiotics with Enhanced Resistance of Gastrointestinal Stresses and Prolonged Intestinal Retention for Synergistic Alleviation of Colitis. ACS Nano,  2023, 17(15), 14775-14791, DOI: 10.1021/acsnano.3c02914.

7. Xiong, H., Wan, Y., Fan, Y., Xu, M., Yan, A., Zhang, Y., Jiang, Q., Wan, H*. Reshaping the imprinting strategy through the thermo-responsive moiety-derived “deep eutectic solvents” effect. Chinese Chemical Letters, 2024, 35(1), 108382. DOI: 10.1016/j.cclet.2023.108382.

8. Xiong, H., Fan, Y., Mao, X., Guo, L., Yan, A., Guo, X., Wan, Y., Wan, H*. Thermosensitive and magnetic molecularly imprinted polymers for selective recognition and extraction of aristolochic acid I. Food Chemistry, 2022, 372, 131250. DOI: 10.1016/j.foodchem.2021.131250.

9. Xiong, H., Guo, L., Mao, X., Tan, T., Wan, H*, Wan, Y. A magnetic hydrophilic molecularly imprinted material with multiple stimuli-response properties for efficient recognition of bisphenol A in beverages. Food Chemistry, 2020, 331, 127311. DOI: 10.1016/j.foodchem.2020.127311.

10. Wang, F., Wan, H# (co-first author). et al. Light sheet microscopy in the near-infrared II window. Nature Methods, 2019, 16, 545-552. DOI: 10.1038/s41592-019-0398-7.

11. Wan, H. et al. A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues. Nature Communications, 2018, 9, 1171. DOI: 10.1038/s41467-018-03505-4.

12. Wan, H. et al. Molecular imaging in the second near-infrared window. Advanced Functional Materials, 2019, 1900566. DOI: 10.1002/adfm.201900566.

13. Wan, H. et al. Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform. Proceedings of the National Academy of Sciences, 2017, 114, 10196-10201. DOI: 10.1073/pnas.1711169114.

14. Wan, H. et al. Developing a bright NIR-II fluorophore with fast renal excretion and its application in molecular imaging of immune checkpoint PD-L1. Advanced Functional Materials, 2018, 28, 1804956. DOI: 10.1002/adfm.201804956.

15. Wan, H. et al. Facile synthesis of yolk-shell magnetic mesoporous carbon microspheres for efficient enrichment of low abundance peptides. Nanoscale, 2013, 5, 10936-10944. DOI: 10.1039/c3nr02932h.

16. Wan, H. et al. Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally NIR controlled chemo-photothermal synergistic cancer therapy. Nanoscale, 2014, 6, 8743-8753. DOI: 10.1039/c4nr01044b.

17. Wan, H. et al. A dendrimer-assisted magnetic grahene-silica hydrophilic composite for efficient and selective enrichment of glycopeptides from the complex sample. Chemical Communications, 2015, 51, 9301-9394. DOI: 10.1039/c5cc01980j.

18. Wan, H. et al. Robust two-photon visualized nanocarrier with the dual targeting ability for controlled chemo-photodynamic synergistic treatment of cancer. ACS Applied Materials & Interfaces, 2015, 7, 9608-9618. DOI: 10.1021/acsami.5b01165.

19. Wan, H. et al. Fabrication of a novel magnetic yolk–shell Fe3O4@mTiO2@mSiO2 nanocomposite for selective enrichment of endogenous phosphopeptides from a complex sample. RSC Advances, 2014, 4, 45804-45808. DOI: 10.1039/c4ra08692a.

20. Ma, Z., Wan, H#. (co-first author), et al. A theranostic agent for cancer therapy and imaging in the second near-infrared window. Nano Research, 2019, 12, 273-279.  DOI: 10.1007/s12274-018-2210-x.

21. Huang, J., Wan, H#. (co-first author), et al. Highly efficient release of glycopeptides from hydrazide beads by a hydroxylamine assisted PNGase F deglycosylation for N-glycoproteome analysis. Analytical Chemistry, 2015, 87, 10199-10204. DOI: 10.1021/acs.analchem.5b02669.

22. Tian, R., Ma, H., Yang, Q., Wan, H#. (co-first author), et al. Rational design of super-contrast NIR-II fluorophore affords high- performance NIR-II molecular imaging guided microsurgery. Chemical Science, 2019, 10, 326. DOI: 10.1039/c8sc03751e.

23. Zhu, S., Herraiz, S., Yue, J., Zhang, M., Wan, H#. (co-first author), et al. 3D NIR-II molecular imaging distinguishes targeted organs with high-performance NIR-II bioconjugates. Advanced Materials, 2018, 30(13), e1705799. DOI: 10.1002/adma.201705799.

24. Zhang, M., Yue, J., Cui, R., Ma, Z., Wan, H# (co-first author), et al. Bright quantum dots emitting at ∼1,600 nm in the NIR-IIb window for deep tissue fluorescence imaging. Proceedings of the National Academy of Sciences, 2018, 115(26), 6590-6595. DOI: 10.1073/pnas.1806153115.

25. Zhang, B., Zhao, S., Wan, H#., (co-first author, cover art), et al. High-resolution DNA size enrichment using a magnetic nano-platform and application in non-invasive prenatal testing. Analyst, 2020, 145, 5733-5739. DOI: 10.1039/d0an00813c.

26. Wang, W., Ma, Z., Zhu, S., Wan, H. et al. Molecular cancer imaging in the second near-infrared window using a renal-excreted NIR-II fluorophore-peptide probe. Advanced Materials, 2018, 30(22), e1800106.  DOI: 10.1002/adma.201800106.

27. Zhong, Y., Ma, Z., Wang, F., Wang, X., Yang, Y., Liu, Y., Zhao, X., Li, J., Du, H., Zhang, M., Cui, Q., Zhu, S., Sun, Q., Wan, H. et al. In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles. Nature Biotechnology, 2019, 37, 1322-1331. DOI: 10.1038/s41587-019-0262-4.

28. Yang, Q., Hu, Z., Zhu, S., Ma, R., Ma, H., Ma, Z., Wan, H. et al. Donor engineering for NIR-II molecular fluorophores with enhanced fluorescent performance. Journal of the American Chemical Society, 2018, 140, 1715-1724. DOI: 10.1021/jacs.7b10334.

29. Zhang, B., Pinsky, P., Ananta, J., Zhao, S., Arulkumar, S., Wan, H. et al. Diagnosis of Zika virus infection on a nanotechnology platform. Nature Medicine, 2017, 23, 548-550. DOI: 10.1038/nm.4302.

30. Zhong, Y., Ma, Z., Zhu, S., Yue, J., Zhang, M., Antaris, A., Yuan, J., Wan, H. et al. Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm. Nature Communications, 2017, 8, 737. DOI: 10.1038/s41467-017-00917-6.

31. Zhu, S., Yang, Q., Antaris, A., Yue, J., Ma, Z., Wang, H., Huang, W., Wan, H. et al. Molecular imaging of biological systems with a clickable dye in the broad 800- to 1700-nm near-infrared window. Proceedings of the National Academy of Sciences, 2017, 114(5), 962-967. DOI: 10.1073/pnas.1617990114.

32. Yang, Q., Ma, Z., Wang, H., Zhou, B., Zhu, S., Zhong, Y., Wang, J., Wan, H. et al. Rational design of molecular fluorophores for biological imaging in the NIR-II window. Advanced Materials, 2017, 29, 1605497. DOI: 10.1002/adma.201605497.

33. Zhu, S., Song, Y., Wang, J., Wan, H. et al. Photoluminescence mechanism in graphene quantum dots: Quantum confinement effect and surface/edge state. Nano Today, 2017, 13, 10-14. DOI: 10.1016/j.nantod.2016.12.006.

34. Liu, B., Li, Y., Wan, H. et al. High performance, multiplexed lung cancer biomarker detection on a plasmonic gold chip. Advanced Functional Materials, 2016, 26, 7994-8002. DOI: 10.1002/adfm.201603547.

35. Liu, F., Wan, H. et al. Preparation of polypropylene spin tips filled with immobilized titanium (IV) ion monolithic adsorbent for robust phosphoproteome analysis. Analytical Chemistry, 2016, 88, 10, 5058-5064. DOI: 10.1021/acs.analchem.6b00701.

36. Xiong, Z., Qin, H., Wan, H. et al. Layer-by-layer assembly of multilayer polysaccharide coated magnetic nanoparticles for the selective enrichment of glycopeptides. Chemical Communications, 2013, 49, 9284-9286. DOI: 10.1039/c3cc45008b.

37. Koh, B., Li, X., Antaris, A., Wan, H. et al. Visible to near-infrared fluorescence enhanced cellular imaging on plasmonic gold chips. Small, 2016, 12(4), 457-465. DOI: 10.1002/smll.201502182.

38. Huang, J., Qin, H., Sun, Z., Huang, G., Wan, H. et al. A peptide N-terminal protection strategy for comprehensive glycoproteome analysis using hydrazide chemistry based method. Scientific Reports, 2015, 5, 10164. DOI: 10.1038/srep10164.

39. Li, J., Wang, F., Liu, J., Xiong, Z., Huang, G., Wan, H. et al. Functionalizing with Glycopeptide Dendrimers Significantly Enhances the Hydrophilicity of the Magnetic Nanoparticles. Chemical Communications, 2015, 51, 4093-4096. DOI: 10.1039/c5cc00187k.

40. Zhang, Q., Zhang, Q., Xiong, Z., Wan, H. et al. Facile preparation of mesoporous carbon-silica-coated graphene for the selective enrichment of endogenous peptides. Talanta, 2016, 146, 272-278. DOI: 10.1016/j.talanta.2015.08.068.

41. Zhang, Q., Zhang, Q., Xiong, Z., Wan, H. et al. Facile preparation of carbon-functionalized ordered magnetic mesoporous silica composites for highly selective enrichment of N-glycans. RSC Advances, 2015, 5, 68972-68980. DOI: 10.1039/c5ra11998g.

42. Li, J., Wang, F., Wan, H. et al. Magnetic nanoparticles coated with maltose-functionalized polyethyleneimine for highly efficient enrichment of N-glycopeptides. Journal of Chromatography A, 2015, 1425, 213-220. DOI: 10.1016/j.chroma.2015.11.044.

43. Huang, G., Ou, J., Wang, H., Ji, Y. Wan, H. et al. Synthesis of a stationary phase based on silica modified with branched octadecyl groups by Michael addition and photoinduced thiol-yne click chemistry for the separation of basic compounds. Journal of Separation Science, 2016, 39, 1461-1470. DOI: 10.1002/jssc.201501403.