[1] 2024.10-2026.10 党工委委员、副主任 吉安市井冈山农业科技园管委会

[2] 20191229-至今 副教授 南昌大学

[3] 20170314-20191229 讲师 南昌大学

人参皂苷Rh2通过负调控脂肪酸氧化逆转TAMs表型发挥免疫调节作用的机制研究

基于PPAR-γ调控的脂肪酸氧化研究人参皂苷Rh2/Rh2-O诱导肿瘤相关巨噬细胞复极化的分子机制

特殊医学用途配方食品产品研发—1—陈芳

食品添加剂新品种氨基酰化酶和高纯度L-硒-甲基硒代半胱氨酸标准品的制备及其申报—3—陈芳

基于PI3K/Akt/HIF-1α信号通路研究Rh2-O 抑制肝癌血管生成的作用

基于 CRT迁移信号通路研究Rh2-O诱导癌细胞免疫原性死亡的分子机制

基于TLR4/NF-κB信号通路研究人参皂苷Rh2辛酸酯衍生物对H22荷瘤小鼠的免疫调节作用及其机制

1) 檀朝立，章旭，谢雨晴，盛晶晶，潘瑶，俞燕芳，陈芳．基于UPLC-Q-Exactive-MS/MS 及网络药理学探讨喷雾干燥桑叶酚类物质抗衰老潜在作用机制[J/OL]．食品工业科技. https://link.cnki.net/urlid/11.1759.TS.20250507.1000.002

2) Jiawei Yang, Xu Zhang, Na Wu, Qirui Hu, Jingjing Sheng, Xinyi Zhong, Yao Pan, Yanfang Yu, Ting Luo, Bing Zhang, Zeyuan Deng, Fang Chen*. Research on the anti-aging activity of different mulberry leaf Products: Based on mulberry leaf powder and mulberry leaf extract. Food Bioscience, 2025, 69:106785. 

3) Qi-Rui Hu, Xin-Yi Zhong, Hua Feng, Xu-Chu Li, Zhi-Hong Zhang, Yao Pan, Ting Luo, Ze-Yuan Deng, Fang Chen*. The molecular mechanism of ginsenoside Rh2 and its octyl ester derivative on anti-angiogenesis in cancer treatment: The battle between PI3K and ROS. Journal of Ginseng Research. 2025, 49(2): 208--222.

4) 宋福香,蒲婷,龚志清,凌思婷，章志红，潘瑶，李静，陈芳，邓泽元. 一款低GI乳基代餐粉的研制及其控糖效果研究[J].食品与发酵工业，2025，51( 10) : 198－205.

5) 宋福香，戴珍珍，盛晶晶，陈佳丽，张卉，冯花，潘瑶，邓泽元，陈芳．人参皂苷辛酸酯通过诱导肝癌细胞自噬引起的免疫原性细胞死亡机制研究[J]．中国免疫学杂志. 2025, 41(6):1427-1432.  

6) Xuchu Li, Jinping Li, Qirui Hu, Xu Zhang, Fang Chen. Association of physical weight statuses defined by body mass index (BMI) with molecular subtypes of premenopausal breast cancer: a systematic review and meta-analysis. BREAST CANCER RESEARCH AND TREATMENT, 2024, 203(3):429-447. 

7) 戴珍珍, 黄青昕, 胡淇睿, 吴汉城, 潘瑶, 邓泽元, 陈芳. 人参皂苷辛酸酯通过内质网应激诱导肝癌细胞免疫原性细胞死亡的机制研究[J]．中国免疫学杂志. 2024, 4(40): 767-771, 779.

8) Qi-rui Hu, Huan Hong, Zhi-hong Zhang, Hua Feng, Ting Luo, Jing Li, Ze-yuan Deng, Fang Chen*. Methods on improvements of the poor oral bioavailability of ginsenosides: Pre-processing, structural modification, drug combination, and micro- or nano- delivery system.  Journal of Ginseng Research. 2023, 47(6): 694-705. 

9) Qi-Rui Hu, Qing-Xin Huang, Huan Hong, Yao Pan, Ting Luo, Jing Li, Ze-Yuan Deng, Fang Chen*. Ginsenoside Rh2 and its octyl ester derivative inhibited invasion and metastasis of hepatocellular carcinoma via the c-Jun/COX2/PGE2 pathway. Phytomedicine, 2023. 121: 155131. 

10) Yingchao Huang, Teng Wei, Fang Chen, Chaoli Tan, Zhiqing Gong, Fengxin Wang, Zeyuan Deng, Li Jing. Effects of various thermal treatments on interfacial composition and physical properties of bovine milk fat globules, Food Research International,2023, 167(11):112580

11) Mengmeng Fan, Teng Wei, Xiang Lu, Mengge Liu, Yingchao Huang, Fang Chen, Ting Luo, Yawei Fan, Rong Liu, Zeyuan Deng, Li Jing. Comprehensive quality evaluation and interaction mechanism of processed cheese analogues prepared from starch, protein, and oil from plant sources. Journal of the Science of Food and Agriculture, 2023,103(13).

12) 黄青昕, 刘婷, 胡淇睿, 章旭, 潘瑶, 俞燕芳, 冯建高, 黎小萍, 邓泽元, 陈芳, 基于体外模拟消化、发酵和网络药理学探讨桑叶酚类物质的潜在生物学活性. 中草药. 2023,54(10), 3205-3215. 

13) Qi-rui Hu, Yao Pan, Han-cheng Wu, Zhen-zhen Dai, Qing-xin Huang, Ting Luo, Jing Li, Ze-yuan Deng, Fang Chen*. The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo. Journal of Ginseng Research. 2023,47(2): 173-182 .

14) Qi-rui Hu, Peng-wei Lai, Fang Chen*, Yan-fang Yu, Bing Zhang, Hongyan Li, Rong Liu, Yawei Fan, Ze-yuan Deng*. Whole mulberry leaves as a promising functional food: From the alteration of phenolic compounds during spray drying and in vitro digestion[J]. Journal of Food Science. 2022, 87(3): 1230-1243. 

15) Xiaoping Li, Yexuan Yao, Cheng-Wei Yu, Teng Wei, Qinghua Xi, Li Jing, Fang Chen, Ze‐Yuan Deng, Ting Luo. Modulation of PPARα‐Thermogenesis‐Gut Microbiota Interactions in Obese Mice Administrated with Zingerone. Journal of the Science of Food and Agriculture, 2022, 103(6).

16) Xiaoping Li, Yexuan Yao, Yu Wang, Lun Hua, Min Wu, Fang Chen, Ze-Yuan Deng, Ting Luo. Effect of Hesperidin Supplementation on Liver Metabolomics and Gut Microbiota in a High-Fat Diet-Induced NAFLD Mice Model, Journal of Agricultural and Food Chemistry, 2022, 70(36).

17) Hua Feng, Nan Luo, Fang Chen, Xinyu Li, Yu Wen, Chengwei Liu, Yan Chen, Yongning Wu. Self-Reported Food Allergy Prevalence Among Elementary School Children - Nanchang City, Jiangxi Province, China, 2021. China CDC Weekly,2022, 4(34):761-765.

18) Li, X. ,  Wei, T. ,  Wu, M. ,  Chen, F. ,  Zhang, P. , &  Deng, Z. Y. , et al. Potential metabolic activities of raspberry ketone. Journal of Food Biochemistry. 2022, 46(1): e14018. 

19) Xiaoping Li, Teng Wei, Jingfang Li, Yuan Yuan, Min Wu, Fang Chen, Ze‐Yuan Deng, Ting Luo. Tyrosol Ameliorates the Symptoms of Obesity, Promotes Adipose Thermogenesis, and Modulates the Composition of Gut Microbiota in HFD Fed Mice. Molecular Nutrition & Food Research, 2022, 66(15).

20) Teng Wei, Yingchao Huang, Chen Weng, Fang Chen, Chaoli Tan, Wenqun Liu, Zeyuan Deng, Li Jing. Lipid rafts may affect the coalescence of milk fat globules through phase transition after thermal treatment. Food Chemistry. 2022, 399(37):133867.

21) Han-cheng Wu, Qi-rui Hu, Ting Luo, Wen-cheng Wei, Hui-juan Wu, Jing Li, Liu-feng Zheng, Qun-ying Xu, Ze-yuan Deng*, Fang Chen*. The immunomodulatory effects of ginsenoside derivative Rh2-O on splenic lymphocytes in H22 tumor-bearing mice is partially mediated by TLR4. International Immunopharmacology. 2021, 101(ptB):108316. DOI: 10.1016/j.intimp.2021.108316

22) Peng Bin, Luo Ting, Chen Fang, Wang Mei, Fu Jin-Heng, Zheng Liu-Feng, Li Jing, Deng Ze-Yuan. Stability comparison of four lipases and catalytic mechanism during the synthesis of 1,3-di-oleic-2-medium chain triacylglycerols in a trace water-in-oil system: Experimental analyses and computational simulations. Journal of Food Biochemistry,2021, 45(1).

23) Bin Peng, Ting Luo, Fang Chen, Mei Wang, Liu-Feng Zheng, Li Jing, Ze-Yuan Deng. Medium- and long-chain triglycerides attenuate lipid accumulation and regulate the expression of proteins related to lipid metabolism in oleic acid-induced lipid deposition in human hepatic LO2 cells. Journal of Functional Foods,2021, 78(3,4):104354.

24) Qirui Hu, Xia Li, Fang Chen*, Renkou Wan, Cheng-wei Yu, Jing Li, David JulianMcClements, and Zeyuan Deng*. Microencapsulation of an Essential Oil (Cinnamon Oil) by Spray Drying: Effects of Wall Materials and Storage Conditions on Microcapsule Properties. Journal of Food Processing and Preservation. 2020, 44（11）.

25) Shilian Zheng, ZeyuanDeng, Fang Chen, LiufengZheng, Yao Pan, QianXing, RongTsao, HongyanLi. Synergistic antioxidant effects of petunidin and lycopene in H9c2 cells submitted to hydrogen peroxide: Role of Akt/Nrf2 pathway. JOURNAL OF FOOD SCIENCE. 2020, 85(6): 1752-1763.

26) Sheng-Ben Hu, QianZou, XinLv, Ruo-Lin Zhou, Xian Niu, Chen Weng, Fang Chen, Ya-Wei Fan, Ze-Yuan Deng, Jing Li*. 9t18:1 and 11t18:1 activate the MAPK pathway to regulate the expression of PLA2 and cause inflammation in HUVECs[J]. Food & Function, 2020, 11.

27) Bin Peng, Fang Chen, Xianbiao Liu, Jiang-Ning Hu, Liu-FengZheng, Jing Li, Ze-Yuan Deng⁎. Trace water activity could improve the formation of 1,3-oleic-2-medium T chain-rich triacylglycerols by promoting acyl migration in the lipase RM IM catalyzed interesterification. Food Chemistry 313 (2020) 126130.

28) Fang Chen, Zipei Zhang, Zeyuan Deng, Ruojie Zhang, Guangqin Fan, Da Ma, David Julian McClements*. Controlled-release of antacids from biopolymer microgels under simulated gastric conditions: Impact of bead dimensions, pore size, and alginate/pectin ratio. Food Research International,2018, 106: 745–751.

29) Fang Chen, Zeyuan Deng, Zipei Zhang, Ruojie Zhang, QunyingXu, Guangqin Fan, David Julian McClements. Controlling lipid digestion profiles using mixtures of different types of microgel: alginate beads and carrageenan beads. Journal of food engineering. 2018, 238: 156-163. 

30) Fang Chen, Yong Sun, Yan Qin, Shi-LianZheng, David Julian McClements, Jiang-Ning Hu*, Ze-Yuan Deng*. Antitumor and immunomodulatory effects of ginsenoside Rh2 and its octyl ester derivative in H22 tumor-bearing mice.Journal of functional foods.2017, 32:382-390.

31) Fang Chen, Li Liang, Zipei Zhang, Zeyuan Deng*, Eric Andrew Decker, David Julian McClements*, Inhibition of lipid oxidation in nanoemulsions and filled microgels fortified with omega-3 fatty acids using casein as a natural antioxidant,Food Hydrocolloids.2017, 63: 240-248.

32) Fang Chen, Guang-Qin Fan, Zipei Zhang, Ruojie Zhang, Ze-Yuan Deng*, David Julian McClements*, Encapsulation of omega-3 fatty acids in nanoemulsions and microgels: Impact of delivery system type and protein addition on gastrointestinal fate, Food Research International, 2017, 100: 387-395.

33) Zipei Zhang#, Fang Chen#, Ruojie Zhang, Zeyuan Deng, and David Julian McClements*, Encapsulation of pancreatic lipase in hydrogel beads with self-regulating internal pH microenvironments: Retention of lipase activity after exposure to gastric conditions, J. Agric. Food Chem.2016, 64 (51), 9616-9623.

34) Fang Chen, Bing Zhang, Yong Sun, Zeng-Xing Xiong, Han Peng, Ze-Yuan Deng, Jiang-Ning Hu*, The octyl ester of ginsenoside Rh2 induces lysosomal membrane permeabilization via Bax translocation,Nutrients.2016, 8(5): 244-258.

35) Fang Chen, Shi-LianZheng, Jiang-Ning Hu*, Yong Sun, Yue-Ming He, Han Peng, Bing Zhang, David Julian McClements, and Ze-Yuan Deng*,Octyl Ester of Ginsenoside Rh2 Induces Apoptosis and G1 Cell Cycle Arrest in Human HepG2 Cells by Activating the Extrinsic Apoptotic Pathway and Modulating the Akt/p38 MAPK Signaling Pathway, J. Agric. Food Chem.2016, 64 (40), 7520-7529.

36) Fang Chen, Ze-Yuan Deng, Bing Zhang, Zeng-Xing Xiong, Shi-Lian Zheng, Chao-Li Tan, Jiang-Ning Hu*, Esterification of ginsenoside Rh2 enhanced its cellular uptake and antitumor activity in human HepG2 cells,J. Agric. Food Chem.2016. 64, 253-261.

37) Fang Chen, Ze-Yuan De, Zeng-Xing Xiong, Bing Zhang, Jian-Yuan Yang, Jiang-Ning Hu*,A ROS-mediated lysosomal-mitochondrial pathway is induced by ginsenoside Rh2 in hepatoma HepG2 cells,Food & function.2015, 6, 3828-3837. 

38) Fang Chen, Yong Tao, Cheng Jin, Yang Xu, Bai-Xue Lin*, Enhanced production of polysialic acid by metabolic engineering of Escherichia coli,.Appl. Microbiol. Biotechnol.,2015, 99: 2603-2611.

39) Li Jing, Hu Shengben, He Yueming, ZhuoChendfei, Zhou Ruolin, Chen Fang, Li Hongyan, Deng Zeyuan. 9c11tCLA modulates 11t18:1 and 9t18:1 induced inflammations differently in human umbilical vein endothelial cells[J]. Scientific Reports. 2018, 8(1).

40) Luo Ting, Lei Lin, Chen Fang, ZhengShilian, Deng Zeyuan. Iron homeostasis in the human body and nutritional iron deficiency and solutions in China. Journal of Food Biochemistry. 2018.

41) Sun Yong, HuiQianru, Chen Ran, Li Hongyan, Peng Han, Chen Fang, Deng Zeyuan. Apoptosis in human hepatoma HepG2 cells induced by the phenolics of Tetrastigmahemsleyanum leaves and their antitumor effects in H22 tumor-bearing mice[J]. Journal of Functional Foods, 2018, 40: 349-364.

42) Yong Sun, RongTsao, Fang Chen, Hongyan Li, Jiawen Wang, Han Peng, Ke Zhang, Zeyuan Deng, The phytochemical composition, metabolites, bioavailability and in vivo antioxidant activity of Tetrastigmahemsleyanum leaves in rats. Journal of Functional Foods, 2017, 30: 179-193.

43) Sun Yong, TsaoRong, Chen Fang, Li Hongyan, Peng Han, Jiang Li, Chen Yuanhuan, Deng Zeyuan. The phenolic profiles of Radix Tetrastigma after solid phase extraction (SPE) and their antitumor effects and antioxidant activities in H22 tumor-bearing mice[J]. Food & Function, 2017, 8(11): 4014-4027.

44) Li Liang, Fang Chen, Xingguo Wang, Qingzhe Jin, Eric Andrew Decker, and David Julian McClements, Physical and Oxidative Stability of Flaxseed Oil-in-Water Emulsions Fabricated from Sunflower Lecithins: Impact of Blending Lecithins with Different Phospholipid Profiles. J. Agric. Food Chem. 2017, 65: 4755-4765.

45) BingjingZheng, Zipei Zhang, Fang Chen, Xiang Luo, David Julian McClements, Impact of delivery system type on curcumin stability: Comparison of curcumin degradation in aqueous solutions, emulsions, and hydrogel beads. Food Hydrocolloids. 2017, 71: 187-197.

46) Hu, Jiang-Ning, Zou, Xian Guo, He, Yi, Chen, Fang, Deng, Ze Yuan. Esterification of Quercetin Increases Its Transport Across Human Caco-2 Cells [J]. Journal of food science, 2016, 81(7): 1825-1832. 

47) 杨建远, 陈芳, 宋沥文,等. 油茶籽油提取技术研究进展. 食品与机械, 2016(2):183-187.

48）许杨*, 陈芳, 林白雪, 陶勇. 全细胞催化生产N-乙酰神经氨酸的条件优化 [J]. 微生物学通报, 2013, 40(8): 1331-1338.