[1] 201109-201412 武汉大学 博士研究生

[1] 201507-* 南昌大学公共卫生学院 南昌大学公共卫生学院

JNK-c-JUN调控PICT1/Rps27a/Mdm2通路在微管解聚剂增强p53稳定性中的作用

胞质内PICT1/RPS27a/P53分子轴在尼古丁协同HPV致宫颈癌中的作用及其干预研究

SETDB1调控CCND1/PI3K/AKT通路在尼古丁致肝癌中的作用及其机制

PICT1介导DNA损伤类化合物增强P53蛋白稳定性的分子调控机制

PICT1介导微管解聚类化合物诱导癌细胞中p53蛋白表达的分子调控机制

(1)  Wang H*. Podophyllum derivatives containing fluorine atom in the 3-position of 2-aminopyridine improved the antitumor activity by inducing P53-dependent apoptosis. Med Chem Res. 2017; 26(6): 1279-1290.

(2)  Wang H*, Feng J, Zhou T, Wei L, Zhou J. P-3F, a microtubule polymerization inhibitor enhances P53 stability through the change in localization of RPS27a. Int J Biochem Cell Biol. 2017; 92(12): 53-62.

(3)  Wang H*, Feng J, Zhou T, Wei L, Zhou J. Involvement of RPL11 in the enhancement of P53 stability by a podophyllum derivative, the topoisomerase II inhibitor. Cell Biol Int. 2018; 42(1): 121-129.

(4)  Chen L, Wang H*. Nicotine promotes human papillomavirus (HPV)-immortalized cervical epithelial cells (H8) proliferation by activating RPS27a-Mdm2-P53 pathway in vitro. Toxicol Sci. 2019; 167(2): 408-418.

(5)  Wang H, Liao P, Zeng SX, Lu H*. It takes a team: a gain-of-function story of p53-R249S. J Mol Cell Biol. 2019; 11(4): 277-283.

(6)  Chen L, Wang H*. eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology. 2019; 419(1): 1-10.

(7)  Wang H, Liao P, Zeng SX, Lu H*. Co-targeting p53-R249S and CDK4 synergistically suppresses survival of hepatocellular carcinoma cells. Cancer Biol Ther. 2020; 21(3): 269-277.

(8)  Chen H, Zhang M, Wang Z, Li L, Li Q, Wang H*. The effect of p53-R249S on the suppression of hepatocellular carcinoma cells survival induced by podophyllum derivatives. Anticancer Agents Med Chem. 2020; 20(7): 865-874.

(9)  Wang H*, Chen L, Zhou T, Zhang Z, Zeng C. Nicotine promotes WRL68 cells proliferation due to the mutant p53 gain-of-function by activating CDK6-p53-RS-PIN1-STAT1 signaling pathway. Chem Res Toxicol. 2020; 33(9): 2361-2373.

(10) Wang H*, Chen L, Zhou T, Zhang Z, Zeng C. p53 mutation at serine 249 and its gain of function are highly related to hepatocellular carcinoma after smoking exposure. Public Health Genomics. 2021; 24(3-4): 171-181.

(11) Wang H, Zhao J, Yang J, Wan S, Fu Y, Wang X, Zhou T, Zhang Z, Shen J*. PICT1 is critical for regulating the Rps27a-Mdm2-p53 pathway by microtubule polymerization inhibitor against cervical cancer. Biochim Biophys Acta Mol Cell Res. 2021; 1868(10): 119084.

(12) Rao Z, Shen J, Wang J, Zhang Z, Zhou J, Zhu J, Chen J, Chen W, Wang H*. The role of PICT1 in RPL11/Mdm2/p53 pathway-regulated inhibition of cell growth induced by topoisomerase IIα inhibitor against cervical cancer cell line. Biochem Pharmacol. 2022; 201(1): 115098.

(13) Xu Y, He Z, Chen L, Wang H*. Podophyllotoxin derivatives targeting tubulin: An update (2017-2022). Drug Discov Today. 2023; 28(8): 103640.

(14) Rao Z, Xu Y, He Z, Wang J, Ji H, Zhong Z, Zhou J, Zhou T, Wang H*. Carcinogenicity of nicotine and signal pathways in cancer progression: a review. Environ Chem Lett. 2024; 22: 239-272.

(15) He Z, Xu Y, Rao Z, Zhang Z, Zhou J, Zhou T, Wang H*. The role of α7-nAChR-mediated PI3K/AKT pathway in lung cancer induced by nicotine. Sci Total Environ. 2024; 912: 169604.

(16) Xu Y, Wang J, He Z, Rao Z, Zhang Z, Zhou J, Zhou T, Wang H*. A review on the effect of COX-2-mediated mechanisms on development and progression of gastric cancer induced by nicotine. Biochem Pharmacol. 2024; 220: 115980.

(17) Li Z, Xu Y, Hu Y, He Z, Zhang Z, Zhou J, Zhou T, Wang H*. The critical role of SETDB1-mediated CCND1/PI3K/AKT pathway via p53-RS di-methylation at K370 in the proliferation of WRL68 cells induced by nicotine. Ecotox Environ Safe. 2024; 282: 116686.

(18) Xu Y, He Z, Rao Z, Li Z, Hu Y, Zhang Z, Zhou J, Zhou T, Wang H*. The role of β2-AR/PI3K/AKT pathway in the proliferation, migration and invasion of THLE-2 cells induced by nicotine. Toxicology. 2024; 508: 153924.

(19) Li Z, Ding H, Hu Y, Zhang Z, Wang H*. The dual role of nicotine in the development and progression of hepatocellular carcinoma. Biochem Pharmacol. 2025;242(Pt 1):117256.