学科方向：食品生物技术、食品安全、营养与食品卫生学

所属院系：食品科学与技术国家重点实验室

研究方向

研究方向为食品与人类健康，主要内容包括：

1.食源致病菌及CTC的高效磁分离及快速检测方法研究（基于分子生物学、免疫学及纳米生物技术等）

2.抗菌材料的制备、优化与机理研究（纳米银、复合纳米材料、聚合物等）

3.食品接触及常见纳米材料的毒性及机制研究（生殖及幼龄动物等）

4.功能性食品及组方研发（益生菌、药食同源等）

个人经历

许恒毅，博士、研究员，食品科学与技术国家重点实验室固定研究人员。从事食品生物技术及纳米生物技术等与人类健康相关领域的研究工作。主持或主持完成国家自然科学基金（3项）、教育部高等学校博士学科点专项科研基金（1项）、江西省自然科学基金重大项目（1项）、国家重点实验室项目（3项），以及其他省部级研究项目十余项，曾参与完成973、863、国家自然科学基金等国家及省部级项目十余项。迄今共发表学术论文180余篇（其中第一及通讯作者论文百余篇，影响因子5以上论文20余篇），参编著作3部，以第一发明人获授权国家发明专利30余项（已转让十余项），并担任包括Advanced Materials、ACS nano和Biomaterials等在内的五十余种相关国际出版物的评审人。担任瑞士国家科学基金（SNSF）、国家自然科学基金（NSFC）、江西省自然基金等的评审人。

讲授课程

《基因工程》

《生物工程前沿技术》

《生物工程学科导论》

学术成就

中国毒理学会青年委员会委员，江西省预防医学会卫生毒理专业委员会第六届委员会常务委员，江西省微生物学会理事，江西省菌物学会理事，中华预防医学会微生态学分会青年委员会委员。

承担课题

在研纵向课题：

1.食品中生物性及放射性危害物高效识别与确证关键技术及产品研发，国家重点研发计划“食品安全关键技术研发”专项，子课题负责人，2018.12-2021.12。

2.纳米氧化锌引起的小鼠卵巢功能损伤及基于内质网应激的机制研究，国家自然科学基金面上项目，主持，2018.01-2021.12。

3.CdSe/ZnS量子点对亲代雌鼠的生殖毒性及向子代传递机制，国家自然科学基金地区基金项目，主持，2016.01-2019.12。

论文专著

近三年发表部分IF大于5的论文（2016-2018）

1.Guotai Yang, Xiangyu Meng, Yutong Wang, Mingyao Yan, Zoraida P. Aguilar, Hengyi Xu* (corresponding author). 2-step lectin-magnetic separation (LMS) strategy combined with AuNPs-based colorimetric system for S. aureus detection in blood. Sensors & Actuators: B. Chemical. 2018. 279C, 87-94. DOI: 10.1016/j.snb.2018.09.112. (SCI, 2017 IF=5.667)

2.Shuang Yu, Yizhou Tang, Mingyao Yan, Zoraida P. Aguilar, Weihua Lai, Hengyi Xu* (corresponding author). A fluorescent cascade amplification method for sensitive detection of Salmonella based on magnetic Fe3O4 nanoparticles and hybridization chain reaction. Sensors & Actuators: B. Chemical. 2018. 279C, 31-37. DOI: 10.1016/j.snb.2018.09.091. (SCI, 2017 IF=5.667)

3.Lin Yang, Huijuan Kuang, Wanyi Zhang, Wei Hua, Hengyi Xu* (corresponding author). Quantum dots cause acute systemic toxicity in lactating rats and growth restriction of offspring. Nanoscale. 2018. 10, 11564-11577. DOI: 10.1039/C8NR01248B. (SCI, 2017 IF=7.233)

4.Liju Nie, Fulai Li, Xiaolin Huang, Zoraida P. Aguilar, Yongqiang Andrew Wang, Yonghua Xiong, Fen Fu*, Hengyi Xu* (corresponding author). Folic Acid Targeting for Efficient Isolation and Detection of Ovarian Cancer CTCs from Human Whole Blood Based on Two-Step Binding Strategy. ACS Appl. Mater. Interfaces, 2018. 10 (16), 14055–14062. DOI: 10.1021/acsami.8b02583. (SCI, 2017 IF=8.097)

5.Fulai Li, Fan Li, Dan Luo, Weihua Lai, Yonghua Xiong, Hengyi Xu* (corresponding author). Biotin-exposure-based immunomagnetic separation coupled with nucleic acid lateral flow biosensor for visibly detecting viable Listeria monocytogenes. Analytica Chimica Acta. 2018. 1017, 48-56. DOI: 10.1016/j.aca.2018.02.009. (SCI, 2017 IF=5.123)

6.Fulai Li, Guotai Yang, Zoraida P. Aguilar, Yonghua Xiong, Hengyi Xu* (corresponding author). Affordable and simple method for separating and detecting ovarian cancer circulating tumor cells using BSA coated magnetic nanoprobes modified with folic acid. Sensors & Actuators: B. Chemical. 2018. 262 C, 611-618. DOI: 10.1016/j.snb.2018.02.038. (SCI, 2017 IF=5.667)

7.FulaiLi, FanLi, Zoraida P. Aguilar, YonghuaXiong, Hengyi Xu* (corresponding author). Polyamidoamine (PAMAM) dendrimer-mediated biotin amplified immunomagnetic separation method coupled with flow cytometry for viable Listeria monocytogenes detection. Sensors & Actuators: B. Chemical. 2018. 257 C, 286-294. DOI: 10.1016/j.snb.2017.10.152. (SCI, 2017 IF=5.667)

8.Bei Yu, Fulai Li, Tiancheng Zhao, Fan Li, Baoqing Zhou, Hengyi Xu* (corresponding author). Hybridization chain reaction-based flow cytometric bead sensor for the detection of emetic Bacillus cereus in milk. Sensors & Actuators: B. Chemical. 2018. 256C, 624-631. DOI: 10.1016/j.snb.2017.09.199. (SCI, 2017 IF=5.667)

9.Fan Li, Fulai Li, Guotai Yang, Zoraida P. Aguilar, Weihua Lai, Hengyi Xu* (corresponding author). Asymmetric polymerase chain assay combined with propidium monoazide treatment and unmodified gold nanoparticles for colorimetric detection of viable emetic Bacillus cereus in milk. Sensors & Actuators: B. Chemical. 2018. 255P2, 1455-1461. DOI: 10.1016/j.snb.2017.08.154. (SCI, 2017 IF=5.667)

10.Xiangyu Meng, Guotai Yang, Fulai Li, Taobo Liang, Weihua Lai, and Hengyi Xu* (corresponding author). Sensitive detection of Staphylococcus aureus with vancomycin-conjugated magnetic beads as enrichment carriers combined with flow cytometry. ACS Appl. Mater. Interfaces, 2017. 9 (25), 21464-21472. DOI: 10.1021/acsami.7b05479. (SCI, 2017 IF=8.097)

11.Xiangyu Meng, Fulai Li, Fan Li, Yonghua Xiong, Hengyi Xu* (corresponding author). Vancomycin modified PEGylated-magnetic nanoparticles combined with PCR for efficient enrichment and detection of Listeria monocytogenes. Sensors & Actuators: B. Chemical. 2017. 247C (2017) pp. 546-555. DOI: 10.1016/j.snb.2017.03.079. (SCI, 2017 IF=5.667)

12.Wanyi Zhang#, Lin Yang#, Huijuan Kuang#, Pengfei Yang, Zoraida P. Aguilar, Andrew Wang, Fen Fu*, Hengyi Xu* (corresponding author). Acute toxicity of quantum dots on late pregnancy mice: effects of nanoscale size and surface coating. Journal of Hazardous Materials. 2016. 318(11), 61-69. DOI: 10.1016/j.jhazmat.2016.06.048. (SCI, 2017 IF= 6.434)

13.Huijuan Kuang, Pengfei Yang, Lin Yang, Zoraida P. Aguilar, Hengyi Xu* (corresponding author). Size dependent effect of ZnO nanoparticles on endoplasmic reticulum stress signaling pathway in murine liver. Journal of Hazardous Materials. 2016. 317 (2016), 119-126. DOI: 10.1016/j.jhazmat.2016.05.063. (SCI, 2017 IF= 6.434)

14.Xiaolin Huang, Rui Chen, Hengyi Xu* (corresponding author), Weihua Lai, and Yonghua Xiong*. Nanospherical brush as catalase container for enhancing the detection sensitivity of competitive plasmonic ELISA. Analytical Chemistry. 2016. 88 (3), 1951-1958. 10.1021/acs.analchem.5b04518. (SCI, 2017 IF= 6.042)

15.Wenting Liu#, Liju Nie#, Fulai Li, Zoraida P. Aguilar, Hong Xu, Yonghua Xiong, Fen Fu*, Hengyi Xu* (corresponding author). Folic acid conjugated magnetic iron oxide nanoparticles for nondestructive separation and detection of ovarian cancer cells from whole blood. Biomaterials Science, 2016, 4(1), 159-166. DOI: 10.1039/C5BM00207A. (SCI, 2017 IF=5.831)

16.Xiaolin Huang, Zoraida P. Aguilar, Hengyi Xu* (corresponding author), Weihua Lai and Yonghua Xiong*. Membrane-based Lateral Flow Immunochromatographic Strip with Nanoparticles as Reporters for Detection: A Review. Biosensors and Bioelectronics. 2016. 75, 166-180. DOI: 10.1016/j.bios.2015.08.032 (SCI, 2017 IF=8.173)