学科方向：食品化学与食品营养、食品安全

所属院系：食品学院

研究方向

（1）功能食品化学与食品营养： 功能食品组分及其生物活性研究；

（2）食品安全：食品加工过程组分变化及危害物产生机理及控制研究;

（3）食品分析与检测：食品品质色谱分析检测、分子光谱学等在线快速检测

个人经历

申明月，研究员，博士研究生导师，主要研究方向为食品化学与营养、食品安全。

近年来，主持4项国家自然科学基金项目，以及3项江西省自然科学基金项目；同时作为主要骨干参与完成了“十三五”国家重点研发计划课题、“十二五”国家科技支撑计划项目等。发表 SCI 期刊论文149篇，论文被引6100余次，H 指数43。其中，近5年以第一或通讯作者（含共同）发表 SCI 论文 45 篇，其中SCI一区论文32篇，IF大于10的论文10篇，封面论文2篇，ESI高被引论文2篇。授权国家发明专利8件，积极与企业开展产学研合作，参编国家级教材2部（十二五国家规划教材1部），参编《食品加工过程安全优化与控制》等专著，受邀担任科技部项目评审专家和国家自然科学基金委生命学部项目函审专家以及《Journal of Agricultural and Food Chemistry》、《Food Hydrocolloids》、《Food Chemistry》等多个SCI期刊的审稿专家等。获江西省自然科学奖二等奖两项（分别为第二、第一完成人），2021-2023年连续入选科睿唯安全球“高被引科学家”。

讲授课程

《蛋白质组学》、《生化分离技术》等

学术成就

本人的研究集中于“食药同源”食品活性成分的化学生物学表征及健康效应、食品热加工危害物的生成机制和调控策略两大方向。在“食药同源”食品活性成分的化学生物学表征及健康效应方面，本人围绕灵芝、山药等特色“食药同源”食品，建立了这些特色“食药同源”食品中多糖、蛋白肽、甾醇等活性成分的分离技术，解析了活性组分的化学结构，并利用多组学技术结合分子生物学揭示了上述物质抗炎、免疫调节等生物活性的分子机制。

而在食品热加工危害物的生成机制和调控策略方面，本人从理论深度研究了热加工食品中多种危害物的同步形成及相互作用规律，并建立了相应的减控技术。建立了油炸薯条、罐装果酱、肉制品等热加工食品体系中丙烯酰胺、5-羟甲基糠醛、杂环胺、呋喃等危害物的同步分析方法，研究了上述热加工食品中食品组分、热加工方式与多元危害物生成的关联，揭示
了多元危害物的伴生关系和形成途径。在此基础上，开发了既能同步抑制多种危害物的形成，又能保持热加工食品感官品质的内源性及外源性控制方法和技术。

承担课题

1.    国家自然科学基金项目. 基于肠道菌群-SCFAs-NLRP3及巨噬细胞-MAPK/NF-κB双途径综合探究山药多糖缓解结肠炎的机制. 32.0万元. 2024.01-2027.12

2.    国家自然科学基金项目. 基于同位素示踪和热力学技术探究抗坏血酸参与的美拉德体系中AGEs形成规律及机理. 54.0万元. 2023.01-2026.12

3.    国家自然科学基金项目. 基于硫酸化分子修饰与Toll样受体通路的怀山药多糖免疫调节活性增效及其作用机理研究. 34.0万元. 2020.01-2023.12

4.    国家自然科学基金项目. 基于代谢组学技术和QSAR模型的黑灵芝甾醇类化合物定量结构-活性关系研究. 51.6万元. 2016.01-2019.12

5.    江西省“双千计划”科技创新高端人才项目-青年类. 100.0万元. 2020.01-2022.12

6.    江西省自然科学基金-杰出青年基金. 婴儿配方乳粉加工过程中晚期糖基化终末产物的形成与控制. 20.0万元. 2023.01-2025.12

7.    江西省自然科学基金项目. 基于细胞模型和代谢组学方法的黑灵芝甾醇类化合物调控胆固醇代谢的分子机制研究. 5万元. 2016.01-2018.12

8.    江西省自然科学基金项目. 绿豆蛋白源抗氧化肽的高效制备关键技术与体外功能活性研究. 6万元. 2017.01-2019.12

论文专著

1.     Yousheng Huang, Jingnan Lu, Mingyu Li, Chang Li, Yuting Wang, Mingyue Shen*, Yi Chen, Shaoping Nie, Maomao Zeng, Jie Chen, Mingyong Xie*. Effect of acidity regulators on acrylamide and 5-hydroxymethylfurfural formation in French fries: The dual role of pH and acid radical ion [J]. Food Chemistry, 2022, 371: 131154.

2.     Zihan Xu, Shanshan Liu, Mingyue Shen*, Jianhua Xie, Jun Yang*. Evaluation of trans fatty acids, carbonyl compounds and bioactive minor components in commercial linseed oils [J]. Food Chemistry, 2022, 369: 130930.

3.     Jingnan Lu, Mingyu Li, Yousheng Huang, Jianhua Xie, Mingyue Shen*, Mingyong Xie. A comprehensive review of advanced glycosylation end products and N-Nitrosamines in thermally processed meat products [J]. Food Control, 2022, 131: 108449.

4.     Lichun Liu, Lei Liu, Jianhua Xie, Mingyue Shen*. Formation mechanism of AGEs in Maillard reaction model systems containing ascorbic acid [J]. Food Chemistry, 2022, 378: 132108.

5.     Mingyu Li, Jingnan Lu, Yousheng Huang, Wenjing Wang, Jianhua Xie, Mingyong Xie, Mingyue Shen*. Quantitative assessment of furosine, furfurals, and advanced glycation end products in different types of commercially available cheeses [J]. Food Control, 2022, 136: 108866.

6.     Mingyu Li, Mingyue Shen*, Jingnan Lu, Jun Yang, Yousheng Huang, Lei Liu, Heyu Fan, Jianhua Xie, Mingyong Xie. Maillard reaction harmful products in dairy products: Formation, occurrence, analysis, and mitigation strategies [J]. Food Research International, 2022, 151: 110839.

7.     Heyu Fan, Huiyu Hu, Chang Li, Jianhua Xie, Jie Chen, Maomao Zeng, Mingyue Shen*, Mingyong Xie. Effects of cooking factors on the formation of heterocyclic aromatic amines in fried beef patties [J]. Journal of Food Processing and Preservation, 2022, e16288.

8.     Yousheng Huang, Mingyu Li, Jingnan Lu, Huiyu Hu, Yuting Wang, Chang Li, Xiaojun Huang, Yi Chen, Mingyue Shen*, Shaoping Nie, Mingyong Xie*. Inhibitory effect of hydrocolloids and ultrasound treatments on acrylamide and 5-hydroxymethylfurfural formation in French fries [J]. Food Hydrocolloids, 2022, 133:107839.

9.     Xianxiang Chen, Jun Yang, Mingyue Shen*, Yi Chen, Qiang Yu, Jianhua Xie*. Structure, function and advance application of microwave-treated polysaccharide: A review [J]. Trends in Food Science & Technology, 2022, 123, 198-209.

10.   Xuan Liu, Xianxiang Chen, Liuming Xie, Jianhua Xie, Mingyue Shen*. Sulfated Chinese yam polysaccharide enhances immunomodulatory activity of RAW 264.7 cells via TLR4-MAPK/NF-κB signaling pathway [J]. Food & Function, 2022, 13, 1316-1326.

11.   Jianhua Xie, Qianqian Song, Qiang Yu, Yi Chen, Yuzhen Hong, Mingyue Shen*. Dietary polysaccharide from Mung bean [Vigna radiate (Linn.) Wilczek] skin modulates gut microbiota and short chain fatty acids in mice [J]. International Journal of Food Science & Technology, 2022, 57(5), 2581-2589.

12.   Shanshan Zhao, Huiyu Hu, Jianhua Xie, Mingyue Shen*. Investigation into the contents of nutrients, Nε-carboxymethyllysine and Nε-carboxyethyllysine in various commercially canned fishes to find the correlation between them [J]. Journal of Food Composition and Analysis, 2021, 96: 103737.

13.   Mingyue Shen, Lichun Liu, Fan Zhang, Yujie Jiang, Zhengbo Huang, Jianhua Xie, Yadong Zhong, Shaoping Nie*, Mingyong Xie. Effects of Processing Parameters on Furan Formation in Canned Strawberry Jam [J]. Food Chemistry, 2021, 358: 129819.

14.   Lichun Liu, Huiyu Hu, Yanpeng Yu, Jiahui Zhao, Lanlan Yuan, Shanshan Liu, Shanshan Zhao, Rong Huang, Jianhua Xie, Mingyue Shen*. Characterization and identification of different Chinese fermented vinegars based on their volatile components [J]. Journal of Food Biochemistry, 2021, 45(3): e13670.

15.   Shanshan Liu, Huiyu Hu, Yanpeng Yu, Jiahui Zhao, Lichun Liu, Shanshan Zhao, Jianhua Xie, Chang Li, Mingyue Shen*. Simultaneous determination of tocopherols, phytosterols and squalene in vegetable oils by high performance liquid chromatography-tandem mass spectrometry [J]. Food Analytical Methods, 2021, 14(8): 1567-1576.

16.   Shanshan Liu, Yadong Zhong, Mingyue Shen*, YuxuanYan, Yanpeng Yu, Jianhua Xie, Shaoping Nie, Mingyong Xie. Changes in fatty acids and formation of carbonyl compounds during frying of rice cakes and hairtails [J]. Journal of Food Composition and Analysis, 2021, 101: 103937.

17.   Mingyue Shen, Shanshan Zhao, Fan Zhang, Mingquan Huang*, Jianhua Xie*. Characterization and authentication of olive, camellia and other vegetable oils by combination of chromatographic and chemometric techniques: role of fatty acids, tocopherols, sterols and squalene [J]. European Food Research and Technology, 2021, 247(2): 411-426.

18.   Liuming Xie, Mingyue Shen*, Zhijun Wang, Jianhua Xie*. Structure, function and food applications of carboxymethylated polysaccharides: A comprehensive review [J]. Trends in Food Science & Technology, 2021, 118, 539-557.

19.   Yue Yu, Mingyue Shen*, Qiang Yu, Yi Chen, Jianhua Xie*. Sulfation modification enchances the intestinal regulation of Cyclocarya paliurus polysaccharides in cyclophosphamide-treated mice via restoring intestinal mucosal barrier function and modulating gut microbiota [J]. Food & Function, 2021, 12, 12278-12290

20.   Jianhua Xie, Yanming Ren, Yuehuan Xiao, Yu Luo, Mingyue Shen*. Interactions between tapioca starch and Mesona chinensis polysaccharide: Effects of urea and NaCl [J]. Food Hydrocolloids, 2021, 111, 106268. 

21.   Rong Huang, Jianhua Xie, Xuan Liu, Mingyue Shen*. Sulfated modification enhances the modulatory effect of yam polysaccharide on gut microbiota in cyclophosphamide-treated mice [J]. Food Research International, 2021,145,110393

22.  Mingyue Shen, Xianxiang Chen, Lixin Huang, Qiang Yu, Yi Chen, Jianhua Xie*. Sulfated Mesona chinensis polysaccharide enhance the immunomodulatory activities of cyclophosphamide-treated mice [J]. Journal of Functional Foods, 2021. 76,104321.

23.   Yu Luo, Xiuying Han, Mingyue Shen*, Jun Yang, Yanming Ren, Jianhua Xie*. Mesona chinensis polysaccharide on the thermal, structural and digestibility properties of waxy and normal maize starches [J]. Food Hydrocolloids, 2021, 112, 106317.

24.   Yanming Ren#, Wenhao Xiao#, Liyuan Rong, Xiuying Han, Mingyue Shen*, Wenmeng Liu, Yu Luo, Jianhua Xie*. The role of alkali in sweet potato starch-Mesona chinensis Benth polysaccharide gels: Gelation, rheological and structural properties [J]. International Journal of Biological Macromolecules, 2021, 170, 366-374.

25.   Ting Wu, Mingyue Shen*, Qiang Yu, Yi Chen, Xianxiang Chen, Jun Yang, Lixin Huang, Xiaomei Guo, JianhuaXie*. Cyclocarya paliurus polysaccharide improves metabolic function of gut microbiota by regulating short-chain fatty acids and gut microbiota composition [J]. Food Research International, 2021, 141, 110119. 

26.   Yanming Ren, Zhiwen Wu, Mingyue Shen*, Liyuan Rong, Wenmeng Liu, Wenhao Xiao, Jianhua Xie*. Improve properties of sweet potato starch film using dual effects: Combination Mesona chinensis Benth polysaccharide and sodium carbonate [J]. LWT-Food Science and Technology, 2021, 140, 110679.

27.   Xianxiang Chen, Yikun Wang, Mingyue Shen*, Qiang Yu, Yi Chen, Lixin Huang, Jianhua Xie*. The water-soluble non-starch polysaccharides from natural resources against excessive oxidative stress: A potential health-promoting effect and its mechanisms [J]. International Journal of Biological Macromolecules, 2021, 171,320-330. 

28.   Liuming Xie, Mingyue Shen*, Yuzhen Hong, Hedan Ye, Lixin Huang, Jianhua Xie*. Chemical modifications of polysaccharides and their anti-tumor activities [J]. Carbohydrate Polymers, 2020,229, 115436. 

29.   Rong Huang, Mingyue Shen*, Yue Yu, Xuan Liu, Jianhua Xie*. Physicochemical characterization and immunomodulatory activity of sulfated Chinese yam polysaccharide [J]. International Journal of Biological Macromolecules, 2020, 165, 635-644. 

30.   Lanlan Yuan #, Fan Zhang#, Shuo Jia, Jianhua Xie*, Mingyue Shen*. Differences between phytosterols with different structures in regulating cholesterol synthesis, transport and metabolism in Caco-2 cells [J]. Journal of Functional Foods, 2020, 65, 103715. 

31.   Jianhua Xie, Hedan Ye, Mengxia Du, Qiang Yu, Yi Chen, Mingyue Shen*. Mung bean protein hydrolysates protect mouse liver cell line Nctc-1469 Cell from hydrogen peroxide-induced vell injury [J]. Foods, 2020, 9(1), 14. 

32.   Wenjie Wang, Mingyue Shen*, Lian Jiang, Qianqian Song, Sucheng Liu, JianhuaXie*. Influence of Mesona blumes polysaccharide on the gel properties and microstructure of acid-induced soy protein isolate gels [J]. Food Chemistry, 2020, 313, 126125. 

33.   Lixin Huang, Mingyue Shen*, Ting Wu, Yue Yu, Qiang Yu, Yi Chen, Jianhua Xie*. Mesona chinensis Benth polysaccharides protect against oxidative stress and immunosuppression in cyclophosphamide-treated mice via MAPKs signal transduction pathways [J]. International Journal of Biological Macromolecules, 2020, 152,766-774.

34.   Suchen Liu, Mingyue Shen*, Yuehuan Xiao, Yu Luo, Jianhua Xie*. Effect of maize, potato, and pea starches with Mesona chinensis polysaccharide on pasting, gelatinization properties, granular morphology and digestion [J]. Food Hydrocolloids, 2020, 108, 106047.

35.   Liuming Xie, Mingyue Shen*, Pingwei Wen, Yuzhen Hong, Xuan Liu, Jianhua Xie*. Preparation, characterization, antioxidant activity and protective effect against cellular oxidative stress of phosphorylated polysaccharide from Cyclocarya paliurus [J]. Food and Chemical Toxicology, 2020, 145, 111754. 

36.   Rong Huang, Jianhua Xie, Yue Yu, Mingyue Shen*. Recent progress in the research of yam mucilage polysaccharides: Isolation, structure and bioactivities [J]. International Journal of Biological Macromolecules, 2020, 155,1262-1269. 

37.   Yousheng Huang, Chang Li, Huiyu Hu, Yuting Wang, Mingyue Shen*, Shaoping Nie, Jie Chen, Maomao Zeng, Mingyong Xie*. Simultaneous determination of acrylamide and 5-hydroxymethylfurfural in heat processed foods employing EMR-Lipid as a new dispersive solid-phase extraction sorbent followed by liquid chromatography-tandem mass spectrometry [J]. Journal of Agricultural and Food Chemistry, 2019, 67(17): 5017-5025.

38.   Yuting Wang, Huiyu Hu, David Julian McClements, Shaoping Nie, Mingyue Shen*, Chang Li, Yousheng Huang, Yadong Zhong, Jie Chen, Maomao Zeng, Mingyong Xie*. pH and lipid unsaturation impact the formation of acrylamide and 5-hydroxymethylfurfural in model system at frying temperature [J]. Food Research International, 2019, 123: 403-413.

39.   Yuting Wang, Huiyu Hu, David Julian McClements, Shaoping Nie, Mingyue Shen*, Chang Li, Yousheng Huang, Jie Chen, Maomao Zeng, Mingyong Xie*. Effect of fatty acids and triglycerides on the formation of lysine-derived advanced glycation end-products in model systems exposed to frying temperature [J]. RSC Advances, 2019, 9(27): 15162-15170.

40.   Lanlan Yuan, Fan Zhang, Mingyue Shen*, Shuo Jia, Jianhua Xie. Phytosterols Suppress Phagocytosis and Inhibit Inflammatory Mediators via ERK Pathway on LPS-Triggered Inflammatory Responses in RAW264.7 Macrophages and the Correlation with Their Structure [J]. Foods, 2019, 8, 582

41.   Jianhua Xie, Mingyue Shen*, Mengxia Du, Ting Wu, Lihua Lin. Physico-chemical properties, antioxidant activities and angiotensin-I converting enzyme inhibitory of protein hydrolysates from Mung bean (Vigna radiate) [J]. Food Chemistry, 2019, 270, 243-250. 

42.   Suchen Liu, Yuehuan Xiao, Mingyue Shen*, Xiaowei Zhang, Wenjie Wang, Jianhua Xie*. Effect of sodium carbonate on the gelation, rheology, texture and structural properties of maize starch-Mesona chinensis polysaccharide gel [J]. Food Hydrocolloids, 2019, 87, 943-951. 

43.   Wenjie Wang, Mingyue Shen*, Lian Jiang, Qianqian Song, Suchen Liu, Mingyong Xie, Jianhua Xie*. Rheological behavior, microstructure characterization and formation mechanism of Mesona blumes polysaccharide gels induced by calcium ions [J]. Food Hydrocolloids, 2019, 94, 136-143. 

44.   Yue Yu#, Mingyue Shen#, Zhijun Wang, Yuanxing Wang, Mingyong Xie, Jianhua Xie*. Sulfated polysaccharide from Cyclocarya paliurus enhances the immunomodulatory activity of macrophages [J]. Carbohydrate Polymers, 2017, 174, 669-676. 

45.   Mingyue Shen, Fan Zhang, Tao Hong, Jianhua Xie, Yuting Wang, Shaoping Nie*, Mingyong Xie. Comparative study of the effects of antioxidants on furan formation during thermal processing in model systems [J]. LWT-Food Science and Technology, 2017, 75: 286-292