个人信息姓名：边学利
国籍：中国
性别：男
毕业院校：厦门大学
学位：博士
电子邮件：bianxueli@ncu.edu.cn
所在单位：基础医学院
个人信息研究兴趣与领域：代谢酶的时空调控、蛋白质翻译后修饰、代谢物作为信号分子的功能及代谢酶的非经典功能。
教研室：医学遗传与细胞生物学
[1] 201209-201808 厦门大学 博士研究生
[2] 200809-201207 南昌大学 大学本科
[1] 202106-至今- 南昌大学 特聘教授
[2] 201904-202106 青岛大学 青岛大学
鉴定组蛋白赖氨酸琥珀酰化修饰结合蛋白及其在脑胶质瘤中的功能
甘油激酶GLYCTK2磷酸化PFK1调控糖酵解促进脑胶质瘤恶性进程机制研究
G6PD SUMO1修饰应答氧化应激调控糖代谢促进肝癌恶性进程机制研究
磷酸果糖激酶PFK2琥珀酰化修饰调控肝癌恶性进展研究
[1] Bian XL#, Chen HZ#, Yang PB#, Li YP#, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q*. Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nature Communications. 2017.8:14420.
[2] Bian XL#, Liu R#, Meng Y#, Xing DM*, Xu DQ*, & Lu ZM*. Lipid metabolism and cancer[J]. Journal of Experimental Medicine, 2021, 218(1).
[3] Xu D#, Shao F#, Bian XL#, Meng Y, Liang TB, Lu ZM*. The evolving landscape of noncanonical functions of metabolic enzymes in cancer and other pathologies[J]. Cell Metabolism, 2021, 33(1): 33-50.
[4] Hou PP#, Luo LJ#, Chen HZ#, Chen QT#, Bian XL#, Wu SF, Zhou JZ, Zhao WX, Liu JM, Wang XM, Zhang ZY, Yao LM, Chen QH, Zhou DW, Wu Q*. Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment. MOLECULAR CELL. 2020 May 20;S1097-2765(20)30305-1.
[5] Bian, X. #, Jiang, H. #, Meng, Y. #, Li, Y. P. #, Fang, J. *, & Lu, Z. *. Regulation of gene expression by glycolytic and gluconeogenic enzymes[J]. Trends in Cell Biology, 2022.
[6] Shao F#, Bian XL#, Jiang HF, Zhao GX, Zhu L, Xu DQ,Wang S, Guo W, Xing DM, Xue Q, Gao YB*, He J*, Lu ZM*. Association of phosphoenolpyruvate carboxykinase 1 protein kinase activity-dependent sterol regulatory element-binding protein 1 activation with prognosis of oesophageal carcinoma[J]. European Journal of Cancer, 2021, 142: 123-131.
[7] Li Y, Zhang F, Hu F, Tong R, Wen Y, Fu G, Bian X*. ERK1-mediated GLYCTK2 phosphorylation promotes fructolysis to sustain glioblastoma survival under glucose deprivation. Cell Death Discovery. 2025 Jun 4;11(1):266.
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